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Scopolamine for prevention of postoperative nausea in gynecologic laparoscopy, a randomized trial.

Abstract：

STUDY OBJECTIVE:We sought to estimate effectiveness of transdermal scopolamine to prevent postoperative nausea and vomiting after gynecologic laparoscopy. DESIGN:Patients were randomized to receive preoperative transdermal scopolamine or placebo. Main outcome measure was incidence of nausea during the first 24 hours postoperatively. Wilcoxon rank sum, Student t, chi2, and Fischer exact tests were used for data analysis (Canadian Task Force classification IA). SETTING:Academic teaching hospital. PATIENTS:A total of 48 patients undergoing gynecologic laparoscopy were studied. INTERVENTIONS:Randomized administration of transdermal Scopolamine or placebo in patients having gynecologic laparoscopic surgery. MEASUREMENTS AND MAIN RESULTS:Patients in the scopolamine group had significantly less incidence of nausea (20.8% vs 62.5%, p = .003) and vomiting (8.3% vs 37.5%, p = .016) during the first 24 hours after surgery. Number needed to treat was 3 (95% CI 1.5, 6.1) for nausea and 4 (95% CI 1.9, 14.6) for vomiting. Symptoms of visual disturbance and dry mouth were more common in the scopolamine group. CONCLUSION:Scopolamine patch significantly reduces incidence and severity of nausea and vomiting in the first 24 hours after gynecologic laparoscopic surgery.

journal_name

J Minim Invasive Gynecol

journal_title

Journal of minimally invasive gynecology

authors

Einarsson JI,Audbergsson BO,Thorsteinsson A

doi

10.1016/j.jmig.2007.08.616

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

26-31

issue

1

eissn

1553-4650

issn

1553-4669

pii

S1553-4650(07)00995-8

journal_volume

15

pub_type

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