Abstract:
BACKGROUND:Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system. Different species of mammals, as well as chicken and catfish have been found to possess strikingly different sets of these receptors. To better understand the evolutionary history of paired receptors, we extended the study of FcR-like genes in amphibian representatives Xenopus tropicalis and Xenopus laevis. RESULTS:The diploid genome of X. tropicalis contains at least 75 genes encoding paired FcR-related receptors designated XFLs. The allotetraploid X. laevis displays many similar genes primarily expressed in lymphoid tissues. Up to 35 domain architectures generated by combinatorial joining of six Ig-domain subtypes and two subtypes of the transmembrane regions were found in XFLs. None of these variants are shared by FcR-related proteins from other studied species. Putative activating XFLs associate with the FcRgamma subunit, and their transmembrane domains are highly similar to those of activating mammalian KIR-related receptors. This argues in favor of a common origin for the FcR and the KIR families. Phylogenetic analysis shows that the entire repertoires of the Xenopus and mammalian FcR-related proteins have emerged after the amphibian-amniotes split. CONCLUSION:FcR- and KIR-related receptors evolved through continual species-specific diversification, most likely by extensive domain shuffling and birth-and-death processes. This mode of evolution raises the possibility that the ancestral function of these paired receptors was a direct interaction with pathogens and that many physiological functions found in the mammalian receptors were secondary acquisitions or specializations.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Guselnikov SV,Ramanayake T,Erilova AY,Mechetina LV,Najakshin AM,Robert J,Taranin AVdoi
10.1186/1471-2148-8-148subject
Has Abstractpub_date
2008-05-16 00:00:00pages
148issn
1471-2148pii
1471-2148-8-148journal_volume
8pub_type
杂志文章abstract:BACKGROUND:How vascular systems and their respiratory pigments evolved is still debated. While many animals present a vascular system, hemoglobin exists as a blood pigment only in a few groups (vertebrates, annelids, a few arthropod and mollusk species). Hemoglobins are formed of globin sub-units, belonging to multigen...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2020-12-29 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-120
更新日期:2011-05-09 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2014-12-12 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2010-02-04 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-12 00:00:00
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更新日期:2011-10-04 00:00:00
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更新日期:2016-06-29 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-09 00:00:00
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更新日期:2011-04-19 00:00:00
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更新日期:2004-07-06 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-31 00:00:00
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更新日期:2016-10-18 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-25 00:00:00
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更新日期:2008-10-01 00:00:00
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更新日期:2008-03-19 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2148-12-88
更新日期:2012-06-14 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-7-33
更新日期:2007-03-02 00:00:00
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更新日期:2019-07-01 00:00:00
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更新日期:2011-12-16 00:00:00
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更新日期:2010-03-12 00:00:00
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更新日期:2009-07-29 00:00:00
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更新日期:2015-11-19 00:00:00
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更新日期:2013-07-03 00:00:00
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更新日期:2004-10-12 00:00:00
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更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:The segmented RNA genome of avian Influenza viruses (AIV) allows genetic reassortment between co-infecting viruses, providing an evolutionary pathway to generate genetic innovation. The genetic diversity (16 haemagglutinin and 9 neuraminidase subtypes) of AIV indicates an extensive reservoir of influenza vir...
journal_title:BMC evolutionary biology
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更新日期:2014-01-24 00:00:00
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更新日期:2019-02-26 00:00:00
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journal_title:BMC evolutionary biology
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更新日期:2014-06-02 00:00:00
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更新日期:2015-10-12 00:00:00
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journal_title:BMC evolutionary biology
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doi:10.1186/s12862-020-01698-1
更新日期:2020-10-19 00:00:00