Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour.

abstract：:It is well established that ischemia-induced release of glutamate and the subsequent activation of post-synaptic glutamate receptors are important processes involved in the development of ischemic neuronal damage. Moderate intraischemic hypothermia attenuates glutamate release and confers protection from ischemic dama...

journal_title：Journal of neurochemistry

authors： Busto R,Globus MY,Neary JT,Ginsberg MD

更新日期：1994-09-01 00:00:00

abstract：:Aquaporin-4, a predominant water channel in the brain, is specifically expressed in astrocyte endfeet and plays a central role in water homeostasis, neuronal activity, and cell migration in the brain. It has two dominant isoforms called M1 and M23, whose mRNA is driven by distinct promoters located upstream of exons 0...

journal_title：Journal of neurochemistry

authors： Abe Y,Ikeshima-Kataoka H,Goda W,Niikura T,Yasui M

更新日期：2012-03-01 00:00:00

abstract：:[3H]Ouabain binding was studied in sections of rabbit somatosensory cortex by quantitative autoradiography and in rabbit brain microsomal membranes using a conventional filtration assay. KD values of 8-12 nM for specific high-affinity binding of [3H]ouabain were found by both methods. High-affinity binding was not uni...

journal_title：Journal of neurochemistry

authors： Antonelli MC,Baskin DG,Garland M,Stahl WL

更新日期：1989-01-01 00:00:00

abstract：:The extension of microglial processes toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y(12) by extracellular ATP. We recently showed that P2Y(12) stimulation by ATP induces microglial process extension in collagen gels. In the present study, we found that a P2Y(12) agonis...

journal_title：Journal of neurochemistry

authors： Ohsawa K,Sanagi T,Nakamura Y,Suzuki E,Inoue K,Kohsaka S

更新日期：2012-04-01 00:00:00

abstract：:We have demonstrated previously that D1 dopamine receptors are coupled to both Gs alpha and Go alpha. We examine here the coupling between human D5 dopamine receptors and G proteins in transfected rat pituitary GH4C1 cells. Similar to D1 receptors, cholera toxin treatment of cells reduced, but did not abolish, D5 agon...

journal_title：Journal of neurochemistry

authors： Sidhu A,Kimura K,Uh M,White BH,Patel S

更新日期：1998-06-01 00:00:00

abstract：:The purpose of the present study was to clarify the expression, transport properties and regulation of ATP-binding cassette G2 (ABCG2) transporter at the rat blood-brain barrier (BBB). The rat homologue of ABCG2 (rABCG2) was cloned from rat brain capillary fraction. In rABCG2-transfected HEK293 cells, rABCG2 was detec...

journal_title：Journal of neurochemistry

authors： Hori S,Ohtsuki S,Tachikawa M,Kimura N,Kondo T,Watanabe M,Nakashima E,Terasaki T

更新日期：2004-08-01 00:00:00

abstract：:The activities of monoamine oxidase A (MAO A) and monoamine oxidase B (MAO B) represent two independent types of substrate binding site, as indicated by experiments with selective inhibitors and also by substrate competition. We have tried to determine whether A and B active sites of human brain and liver MAO are loca...

journal_title：Journal of neurochemistry

authors： White HL,Stine DK

更新日期：1982-05-01 00:00:00

abstract：:The role of neuroactive steroids and GABA(A) receptors in the generation of spontaneous spike-and-wave discharges (SWDs) was investigated in the WAG/Rij rat model of absence epilepsy. The plasma, cerebrocortical, and thalamic concentrations of the progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5a...

journal_title：Journal of neurochemistry

authors： Pisu MG,Mostallino MC,Dore R,Mura ML,Maciocco E,Russo E,De Sarro G,Serra M

更新日期：2008-09-01 00:00:00

abstract：:Spiroxatrine has been reported to be a 5-HT1A serotonin receptor antagonist. Therefore [3H]spiroxatrine was synthesized and its 5-HT1A receptor binding properties in homogenates of rat hippocampal membranes were characterized with the expectation that it would be the first 5-HT1A antagonist radioligand. [3H]8-Hydroxyd...

journal_title：Journal of neurochemistry

authors： Herrick-Davis K,Titeler M

更新日期：1988-02-01 00:00:00

abstract：:Carboxypeptidase E (CPE) functions in the posttranslational processing of bioactive peptides. Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites nea...

journal_title：Journal of neurochemistry

authors： Song L,Fricker L

更新日期：1995-07-01 00:00:00

abstract：:Guanidino compounds in CSF of 57 human subjects were determined fluorometrically after reaction with phenanthrenequinone in alkali solution, using HPLC. Creatinine (65.2 +/- 13.4 nmol/ml), arginine (24.7 +/- 6.4 nmol/ml), and homoarginine (0.7 +/- 0.3 nmol/ml) were found in all subjects. Trace amounts of guanidinosucc...

journal_title：Journal of neurochemistry

authors： Mori A,Watanabe Y,Fujimoto N

更新日期：1982-02-01 00:00:00

abstract：:Ten-minute incubation with 1 mM S-nitroso-L-cysteine (NO-CYS), a nitric oxide (NO) generator, induced a 3.5-fold increase in the basal dopamine (DA) efflux from rat striatal slices. Reduced hemoglobin (100 microM), a NO scavenger, blocked this response. Nomifensine (10 microM), an inhibitor of high-affinity DA transpo...

journal_title：Journal of neurochemistry

authors： Lonart G,Johnson KM

更新日期：1994-12-01 00:00:00

abstract：:Parameters affecting the binding of [3H]glycine to membrane fractions isolated from the cerebral cortex, midbrain, cerebellum, medulla oblongata, and spinal cord of the rat were investigated in a Na+-free medium. A [3H]glycine binding assay was established in which the binding was specific, saturable, pH-sensitive, an...

journal_title：Journal of neurochemistry

authors： Kishimoto H,Simon JR,Aprison MH

更新日期：1981-10-01 00:00:00

abstract：:Caspase cleavage of amyloid precursor protein (APP) has been reported to be important in amyloid beta protein (Aβ)-mediated neurotoxicity. However, the underlying mechanisms are not clearly understood. In this study, we explored the effect of caspase cleavage of APP on tau phosphorylation in relation to Aβ. We found t...

journal_title：Journal of neurochemistry

authors： Park SS,Jung HJ,Kim YJ,Park TK,Kim C,Choi H,Mook-Jung IH,Koo EH,Park SA

更新日期：2012-12-01 00:00:00

abstract：:The effect of selective inhibition of monoamine oxidase (MAO) subtypes A and B on striatal metabolism of DOPA to dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid; HVA) was studied in halothane-anesthetized rats 3 weeks after unilateral 6-hydroxydopamine...

journal_title：Journal of neurochemistry

authors： Finberg JP,Wang J,Goldstein DS,Kopin IJ,Bankiewicz KS

更新日期：1995-09-01 00:00:00

abstract：:The N-type voltage-dependent calcium channels play a significant role in neurotransmitter release. The alpha1B subunit of the N-type calcium channel functions as the primary subunit that forms the pore and contains the structural motifs that mediate the pharmacological and gating properties of the channel. We report o...

journal_title：Journal of neurochemistry

authors： Ghasemzadeh MB,Pierce RC,Kalivas PW

更新日期：1999-10-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, are considered incurable and significantly reduce the quality of life of the patients. A variety of drugs that modulate neurotransmitter levels have been used for the treatment of the neurodegenerative diseases but ...

journal_title：Journal of neurochemistry

authors： Huang M,Rathore SS,Lindau M

更新日期：2019-10-01 00:00:00

abstract：:cDNAs have been cloned that encode the chicken (Gallus domesticus) gamma-aminobutyric acidA receptor gamma 1 subunit, the mature sequence of which shares 90, 79, and 69% identity with those of the rat gamma 1, gamma 2, and gamma 3 subunits, respectively. In situ hybridization reveals that there are pronounced differen...

journal_title：Journal of neurochemistry

authors： Glencorse TA,Darlison MG,Barnard EA,Bateson AN

更新日期：1993-12-01 00:00:00

abstract：:MDL 72145, (E)-2-(3',4'-dimethoxyphenyl)-3-fluoroallylamine hydrochloride, was designed and synthesised as a potential enzyme-activated irreversible inhibitor of monoamine oxidase (MAO). In vitro, the compound displayed time-dependent pseudo-first-order irreversible inhibitory characteristics with high selectivity for...

journal_title：Journal of neurochemistry

authors： Zreika M,McDonald IA,Bey P,Palfreyman MG

更新日期：1984-08-01 00:00:00

abstract：:Although alterations in mitochondrial dynamics are associated with cellular responses to injury, the functional role of these dynamic changes in ischemic neurons is underexplored. One of these dynamic responses to injury includes mitochondrial biogenesis. Various sublethal pre-conditioning stimuli that induce an ische...

journal_title：Journal of neurochemistry

authors： Stetler RA,Leak RK,Yin W,Zhang L,Wang S,Gao Y,Chen J

更新日期：2012-11-01 00:00:00

abstract：:The neurotoxic properties of the dietary excitotoxins beta-N-methylamino-L-alanine and beta-N-oxalylamino-L-alanine have been studied in rat cerebellar granule cells and compared with those of glutamate. Glutamate caused dose-dependent death of cerebellar granule cells after a 30-min exposure when viability was assess...

journal_title：Journal of neurochemistry

authors： Staton PC,Bristow DR

更新日期：1997-10-01 00:00:00

abstract：:Addiction is thought to be a memory process between perception and environmental cues and addicted patients often relapse when they come into contact with the drug-related context once again. Here, we used a conditioned place preference protocol to seek a more effective extinction methodology of methamphetamine (METH)...

journal_title：Journal of neurochemistry

authors： Huang CH,Yu YJ,Chang CH,Gean PW

更新日期：2016-04-01 00:00:00

abstract：:Growth cone response to the bifunctional guidance cue netrin-1 is regulated by the activity of intracellular signaling intermediates such as protein kinase C-alpha (PKCalpha) and adenylyl cyclase. Among the diverse cellular events these enzymes regulate is receptor trafficking. Netrin-1, itself, may govern the activit...

journal_title：Journal of neurochemistry

authors： McKenna WL,Wong-Staal C,Kim GC,Macias H,Hinck L,Bartoe JL

更新日期：2008-02-01 00:00:00

abstract：:Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-PHDs) are important targets against oxidative stress. We hypothesized that inhibition HIF-PHD by adaptaquin reduces hypoxic-ischemic brain injury in a neonatal mouse model. The pups were treated intraperitoneally immediately with adaptaquin after hypoxia-ischemia (HI...

journal_title：Journal of neurochemistry

authors： Li K,Li T,Wang Y,Xu Y,Zhang S,Culmsee C,Wang X,Zhu C

更新日期：2019-09-01 00:00:00

abstract：:Mouse models of MPTP intoxication have been used extensively to explore the molecular mechanisms of Parkinson's disease. However, these models present some limitations since; (i) Dopaminergic (DA) cell death occurs rapidly in contrast to the presumably slow evolution of the disease process. (ii) Some of the key histol...

journal_title：Journal of neurochemistry

authors： Alvarez-Fischer D,Guerreiro S,Hunot S,Saurini F,Marien M,Sokoloff P,Hirsch EC,Hartmann A,Michel PP

更新日期：2008-11-01 00:00:00

abstract：:The structure and function of mitochondrial respiratory-chain enzyme proteins were studied postmortem in the substantia nigra of nine patients with Parkinson's disease and nine matched controls. Total protein and mitochondrial mass were similar in the two groups. NADH-ubiquinone reductase (Complex I) and NADH cytochro...

journal_title：Journal of neurochemistry

authors： Schapira AH,Cooper JM,Dexter D,Clark JB,Jenner P,Marsden CD

更新日期：1990-03-01 00:00:00

abstract：:Sequence data from key fragments of the P2 protein established the order of cyanogen bromide (CNBr) peptides in the structure of the protein and the primary structure for approximately one-half of the molecule. Data were obtained from the three tryptic peptides of blocked NH2-terminal CNBr peptide (CN3), the large CNB...

journal_title：Journal of neurochemistry

authors： Weise MJ,Hsieh DL,Levit S,Brostoff SW

更新日期：1980-08-01 00:00:00

abstract：:The release of endogenous 5-hydroxytryptamine (5-HT), substance P (SP), and neurokinin A (NKA) from superfused tissue slices of rat ventral lumbar spinal cord, where SP and NKA coexist with 5-HT in terminals of descending bulbospinal neurons, was investigated. Electrical field stimulation was performed using square-wa...

journal_title：Journal of neurochemistry

authors： Franck J,Brodin E,Fried G

更新日期：1993-08-01 00:00:00

abstract：:Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as well as in several debilitating central nervous system (CNS) disorders. In order to fully elucidate the diverse roles of nicotinic acetylcholine receptors in CNS function and dysfunction, a detailed knowledge of their cellular an...

journal_title：Journal of neurochemistry

authors： Moser N,Mechawar N,Jones I,Gochberg-Sarver A,Orr-Urtreger A,Plomann M,Salas R,Molles B,Marubio L,Roth U,Maskos U,Winzer-Serhan U,Bourgeois JP,Le Sourd AM,De Biasi M,Schröder H,Lindstrom J,Maelicke A,Changeux JP,Weve

更新日期：2007-07-01 00:00:00

abstract：:Exposure of bovine chromaffin cells in primary culture to 0.01-1 microM reserpine caused a dose- and time-dependent increase in intracellular levels of the amidated enkephalin peptide metorphamide. Maximal levels (approximately 800% of control) were obtained at 0.1 microM reserpine and increased levels were apparent b...

journal_title：Journal of neurochemistry

authors： Eiden LE,Zamir N

更新日期：1986-05-01 00:00:00