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Phase II study of azacitidine to restore responsiveness of prostate cancer to hormonal therapy.

Abstract：

:Epigenetic alterations, including methylation of key tumor suppressor genes, may play a role in the progression of prostate cancer to a castration-refractory state. Azacitidine, an agent approved for the treatment of myelodysplastic syndromes, appears to exert its antineoplastic effects partly by hypomethylating DNA that leads to the reversal of gene silencing. It is hypothesized that the addition of azacitidine to complete androgen blockade may restore the responsiveness of progressive prostate cancer to hormonal therapy. A phase II trial was designed to evaluate the activity of azacitidine to primarily modulate PSA kinetics, with supportive secondary clinical endpoints. Correlative studies will be performed to detect the biologic activity of azacitidine (increased fetal hemoglobin, plasma DNA methylation) and examine any association with anti-tumor clinical activity.

journal_name

Clin Genitourin Cancer

journal_title

Clinical genitourinary cancer

authors

Sonpavde G,Aparicio A,Guttierez I,Boehm KA,Hutson TE,Berry WR,Asmar L,von Hoff DD

doi

10.3816/CGC.2007.n.036

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

457-9

issue

7

eissn

1558-7673

issn

1938-0682

pii

S1558-7673(11)70122-7

journal_volume

5

pub_type

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