Gastrin is not required for liver regeneration.


BACKGROUND:Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS:Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40%) hepatectomy by measurement of liver weight. Hepatocyte proliferation and circulating gastrin concentrations were measured at the same time points by immunohistochemistry and radioimmunoassay, respectively. RESULTS:There was no significant difference in the rate of liver regeneration between gastrin KO and WT mice. Hepatocyte proliferation in both groups was increased at day 2 but had returned to baseline values by day 10. At day 2, hepatocyte proliferation in the gastrin KO mice was significantly higher than in WT animals, whereas at day 10, proliferation was significantly greater in the WT mice. The circulating gastrin concentration in the WT mice was significantly lower at day 10 than in unoperated WT animals. CONCLUSION:This study suggests that gastrin is not essential for liver regeneration after partial hepatectomy.


ANZ J Surg


ANZ journal of surgery


Dizdarevic A,Harun N,Malcontenti-Wilson C,Shulkes A,Christophi C,Baldwin GS




Has Abstract


2008-01-01 00:00:00














  • Chlorhexidine-induced anaphylaxis in surgical patients: a review of the literature.

    abstract:BACKGROUND:Chlorhexidine (CHL) has antiseptic and disinfectant properties used to prevent hospital-acquired infections. CHL-induced anaphylaxis is poorly reported in surgical literature despite government warnings and growing recognition. The aim of this review is to increase awareness of CHL-induced anaphylaxis in the...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Sharp G,Green S,Rose M

    更新日期:2016-04-01 00:00:00

  • Regional nodal metastasis and 5-year survival in patients with thin melanoma in Queensland: a population-based study.

    abstract:BACKGROUND:Optimal management of regional lymph nodes for thin cutaneous melanoma is uncertain. We evaluated regional lymph node involvement and 5-year melanoma-specific survival (MSS) in patients with thin (≤1 mm) primary melanoma. METHODS:Patients with a melanoma, American Joint Committee on Cancer Staging 8th Editi...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Theile H,Moore J,Dunn N,Cossio D,Forristal CE,Green AC,Smithers BM

    更新日期:2020-04-01 00:00:00

  • Serum interleukin-6 measurement in the diagnosis of acute appendicitis.

    abstract:BACKGROUND:Many attempts have been made to determine ways of decreasing the negative laparotomy rate after a clinical diagnosis of acute appendicitis. The aim of the present study was to determine the effectiveness of serum interleukin-6 (IL-6) concentration in the diagnosis of appendicitis, and in the prevention of no...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Gürleyik G,Gürleyik E,Cetinkaya F,Unalmiser S

    更新日期:2002-09-01 00:00:00

  • Surgical treatment of hepatic haemangiomas: a 15-year experience.

    abstract:BACKGROUND:Hepatic haemangiomas are congenital vascular malformations. They are the most common benign tumours of the liver and are often asymptomatic. Spontaneous or traumatic rupture, intratumoral bleeding, consumption coagulopathy and rapid growth are the mandatory surgical indications. We present our experience ove...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Gourgiotis S,Moustafellos P,Zavos A,Dimopoulos N,Vericouki C,Hadjiyannakis EI

    更新日期:2006-09-01 00:00:00

  • Endoscopic cyst-gastrostomy for pancreatic pseudocysts: refining the indications.

    abstract:BACKGROUND:Pseudocysts are a common consequence of acute pancreatitis and require intervention if symptomatic. Endoscopic management is emerging as a safe and effective alternative to surgery, although its use is not yet widespread. METHODS:We describe our experience of 10 consecutive unselected patients who underwent...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Due SL,Wilson TG,Chung A,Chen JW

    更新日期:2016-05-01 00:00:00

  • Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy.

    abstract:BACKGROUND:Trimodality therapy (TMT; extrapleural pneumonectomy (EPP), chemotherapy and radiation therapy) offers the potential of optimal survival in selected patients with Brigham stage I-II epitheliod mesothelioma based on CT, MRI and PET scanning. We hypothesized that these scanning modalities were inadequate to ac...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Alvarez JM,Hasani A,Segal A,Sterret G,Millward M,Nowak A,Musk W,Bydder S

    更新日期:2009-10-01 00:00:00

  • Operative experience in the Victorian general surgical training programme.

    abstract:BACKGROUND:The Royal Australasian College of Surgeons recommends minimum operative and endoscopy training requirements for advanced trainees in general surgery. This study examines the influences of trainee seniority, geographical location of surgical rotation, and surgeons' remuneration arrangements on the operative a...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Wong K,Birks D

    更新日期:2003-12-01 00:00:00

  • The Surgical Research Society of Australasia.

    abstract:BACKGROUND:The Surgical Research Society of Australasia (SRS) was established in 1961. The main intent was to promote surgical research, especially by young surgeons. The 50th Scientific Meeting of the SRS is due to be held in 2002. METHODS:Selected information was extracted from the programme books for the scientific...

    journal_title:ANZ journal of surgery

    pub_type: 历史文章,杂志文章


    authors: Hall JC,Ludbrook J

    更新日期:2002-10-01 00:00:00

  • Mammary tuberculosis: analysis of thirty-eight patients.

    abstract::Thirty-eight patients with mammary gland tuberculosis were evaluated over a 5-year period presenting to the surgical unit of our institution. Unilateral involvement of the breast in a woman presenting at an average age of 29 years was the commonest observation. A lump in the breast with or without discharging sinuses ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Harris SH,Khan MA,Khan R,Haque F,Syed A,Ansari MM

    更新日期:2006-04-01 00:00:00

  • Can pathological reports of rectal cancer provide national quality indicators?

    abstract:BACKGROUND:Rectal cancer care has become increasingly complex and requires accurate information. The pathology report is a vital tool for accessing information to gauge a patient's prognosis and to guide treatment decisions. The aim of this study was to assess the quality of histopathological reporting and surgery for ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Keane C,Lin AY,Kramer N,Bissett I

    更新日期:2018-09-01 00:00:00

  • Australian audit for the endoluminal repair of abdominal aortic aneurysm: the first 12 months.

    abstract:BACKGROUND:The Australian Safety and Efficacy Register for New Interventional Procedures - Surgical (ASERNIP-S) was contracted by the Commonwealth Department of Health and Aged Care to audit the procedure of endoluminal repair of abdominal aortic aneurysm. The purpose of the audit was to examine the safety and efficacy...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Boult M,Babidge W,Anderson J,Denton M,Fitridge R,Harris J,Lawrence-Brown M,May J,Myerstt K,Maddern G

    更新日期:2002-03-01 00:00:00

  • Orbital exenterations: an 18-year experience from a single head and neck unit.

    abstract:BACKGROUND:To review the outcomes of the patients who undergo orbital exenteration for malignancy. METHODS:A retrospective review of patients who underwent orbital exenteration performed at Royal Prince Alfred and Concord Hospitals between 1990 and 2008. RESULTS:A total of 38 patients were identified. The most common...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Kuo CH,Gao K,Clifford A,Shannon K,Clark J

    更新日期:2011-05-01 00:00:00

  • Trends in publication of general surgical research in New Zealand, 1996-2015.

    abstract:BACKGROUND:Recent analyses of the surgical literature have suggested a general trend towards increasing numbers of published articles and an improved quality of evidence produced. The aim of this bibliometric analysis was to identify trends in the publication of general surgical research in New Zealand from 1996 to 201...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Wells CI,Robertson JP,O'Grady G,Bissett IP

    更新日期:2017-01-01 00:00:00

  • Change in serum albumin level predicts short-term complications in patients with normal preoperative serum albumin after gastrectomy of gastric cancer.

    abstract:BACKGROUND:The purpose of this study was to evaluate the correlation between serum albumin level change (ΔALB) and post-operative complications in patients with normal preoperative serum albumin after gastrectomy of gastric cancer. METHODS:A total of 193 patients undergoing curative (R0) gastrectomy from September 201...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Ai S,Sun F,Liu Z,Yang Z,Wang J,Zhu Z,Du S,Guan W

    更新日期:2019-07-01 00:00:00

  • Patent Blue V dye anaphylaxis: experience of Australian and New Zealand surgeons.

    abstract:BACKGROUND:Patent Blue V dye (PBVD) can cause severe anaphylaxis. For sentinel node biopsy (SNB) in breast cancer patients, controversy exists as to the utility of PBVD in addition to lymphoscintigraphy. This survey assessed Australian and New Zealand breast surgeons' experience of anaphylaxis with PBVD. METHODS:The s...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Wong A,Spillane A,Breast Surgeons of Australia and New Zealand Incorporated (BreastSurgANZ).

    更新日期:2014-01-01 00:00:00

  • Parotidectomy: preoperative investigations and outcomes in a single surgeon practice.

    abstract:BACKGROUND:The aim of this study was to assess the value of fine-needle aspiration cytology (FNAC) as a preoperative evaluation for parotid tumours. METHODS:Prospectively collected data on 77 patients, collected on a parotid database, were retrospectively analysed. Preoperative investigations were carried out and cyto...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Burgess AN,Serpell JW

    更新日期:2008-09-01 00:00:00

  • Experience in dermomyofascial pouch coverage of immediate implants following skin sparing reduction mastectomy.

    abstract:BACKGROUND:Mastectomy for breast cancer treatment and prophylaxis has improved survival for patients. The advantage of implant reconstruction post mastectomy is that it avoids an additional donor site with its associated morbidity, which post-mastectomy autologous reconstruction necessitates. However, the deficiency of...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Chang LY,Hargreaves W,Segara D,Moisidis E

    更新日期:2013-03-01 00:00:00

  • Central nervous system interleukin-8 production following neck of femur fracture.

    abstract:AIM:To establish a proinflammatory cytokine profile of the cerebrospinal fluid (CSF) following trauma. BACKGROUND:Trauma is associated with a postinjury syndrome consisting of loss of weight and nitrogen, pyrexia, anorexia and fatigue. It has been proposed that cytokines are pathophysiologically involved in this syndr...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Chuang D,Power SE,Dunbar PR,Hill AG

    更新日期:2005-09-01 00:00:00

  • Management of recurrent bleeding after pancreatoduodenectomy.

    abstract:BACKGROUND:Re-bleeding after management of a first haemorrhage following pancreatic surgery is an ever-present danger and often presents diagnostic and management dilemmas. METHODS:All cases of post-pancreatectomy haemorrhage (PPH) following pancreatoduodenectomy were identified from a tertiary referral, clinical data...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Staerkle RF,Gundara JS,Hugh TJ,Maher R,Steinfort B,Samra JS

    更新日期:2018-05-01 00:00:00

  • Pilonidal sinus: is histological examination necessary?

    abstract:BACKGROUND:Pilonidal sinus is a common pathology occurring in a number of sites including the gluteal cleft between the buttocks. Surgery is the principal mode of treatment with a variety of techniques proposed to cure the disease and prevent recurrence. The rate of malignant degeneration is estimated at 0.1% in patien...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: 'Otutaha B,Park B,Xia W,Hill AG

    更新日期:2020-12-28 00:00:00

  • Trainee surgeons and patient outcomes in carotid endarterectomy: a retrospective cohort study.

    abstract:BACKGROUND:In Australia and New Zealand, more than 2000 carotid endarterectomies are performed annually. The major morbidities arising from this procedure are post-operative stroke, cranial nerve injury and death. Carotid endarterectomy surgery is a key component of the vascular surgical training programme. We assessed...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Johnson NW,Smoll NR,Tan C,Brooks CE

    更新日期:2020-09-01 00:00:00

  • Time to computed tomography scanning for major trauma patients: the Australian reality.

    abstract:BACKGROUND:Computed tomography (CT) can facilitate the diagnosis of life-threatening injuries in polytrauma patients. Reported times to imaging vary widely, but it has been suggested that rapid whole body scanning improves mortality rates. The aim of this study was to determine the time to CT for severe polytrauma pati...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Easton R,Sisak K,Balogh ZJ

    更新日期:2012-09-01 00:00:00

  • Malignant progression of anal intra-epithelial neoplasia.

    abstract:BACKGROUND:Anal intra-epithelial neoplasia (AIN) is believed to be a precursor to squamous cell carcinoma of the anus. The risk of developing anal cancer in patients with AIN, although known to occur, has been thought to be relatively low. This study reviews our experience with AIN, reviewing the incidence and risk fac...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Watson AJ,Smith BB,Whitehead MR,Sykes PH,Frizelle FA

    更新日期:2006-08-01 00:00:00

  • Diarrhoea after laparoscopic cholecystectomy: incidence and main determinants.

    abstract:BACKGROUND:Data on the effect of laparoscopic cholecystectomy (LC) on bowel function are controversial. The aim of this study was to determine the incidence of postcholecystectomy diarrhoea (PCD) and to identify patient characteristics that can be used as predictors in daily practice. METHODS:In 100 consecutive patien...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Fisher M,Spilias DC,Tong LK

    更新日期:2008-06-01 00:00:00

  • The coronal aorto-mesenteric orientation theory for post-operative nausea and vomiting following scoliosis surgery in children: a pilot study.

    abstract:BACKGROUND:Post-operative nausea and vomiting (PONV) is often encountered following corrective scoliosis surgery in children, frequently attributed to high-dose opiate administration. PONV is a frequent cause of prolonged hospital stay. Mechanisms related to transient partial duodenal compression by narrow angulation o...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Dounas GD,Cundy TP,Smith ML,Gent R,Antoniou G,Sutherland LM,Cundy PJ

    更新日期:2020-11-26 00:00:00

  • Prolonged surgical duration, higher body mass index and current smoking increases risk of surgical site infection after intra-articular fracture of distal femur.

    abstract:BACKGROUND:This study aimed to investigate incidence of surgical site infection (SSI) following the surgery of intra-articular fractures of distal femur. METHODS:Between July 2014 and December 2017, inpatient medical records of consecutive patients who had intra-articular fractures of distal femur treated by open redu...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Xu H,Yu L,Li Y,Gong Z

    更新日期:2019-06-01 00:00:00

  • Does knee position during wound closure alter patella height following total knee arthroplasty?

    abstract:BACKGROUND:Patella infera is a known complication of total knee arthroplasty, and the method of soft tissue closure is a possible contributing factor. The aim of our study was to evaluate the effect of knee position during surgical closure of capsule, subcutaneous tissue and skin on patella tendon length after total kn...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Clark S,Tee L,Sutherland A

    更新日期:2019-03-01 00:00:00

  • Video-assisted thoracoscopic surgery versus open thoracotomy for pulmonary metastasectomy: a systematic review.

    abstract:BACKGROUND:Pulmonary metastasectomy has become a popular procedure for patients with pulmonary metastases. It can be achieved via the traditional open thoracotomy or the more recently developed video-assisted thoracoscopic surgery (VATS). However, there has been much debate as to which approach is better in terms of de...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审


    authors: Cheang MY,Herle P,Pradhan N,Antippa P

    更新日期:2015-06-01 00:00:00

  • Safety of laparoscopic appendicectomy during pregnancy: a systematic review and meta-analysis.

    abstract:BACKGROUND:Acute appendicitis is the most common non-obstetric surgical presentation during pregnancy. There were concerns that laparoscopic appendicectomy increases the risk of foetal loss compared to an open approach. Therefore, with recent advances in perioperative care, it is likely the risk has changed. Here, we p...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,meta分析


    authors: Chakraborty J,Kong JC,Su WK,Gourlas P,Gillespie C,Slack T,Morris B,Lutton N

    更新日期:2019-11-01 00:00:00

  • Audit of the Douglas Hocking Research Institute bone bank: ten years of non-irradiated bone graft.

    abstract:BACKGROUND:An audit performed in the use of non-irradiated femoral head bone graft at the Geelong Hospital over a 10-year period. While it is thought the non-irradiated bone graft provides a better structural construct there is theoretical increased risk of infection transmission. METHODS:We performed a retrospective ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Love D,Pritchard M,Burgess T,Van Der Meer G,Page R,Williams S

    更新日期:2009-01-01 00:00:00