[Bone marrow stromal damage mediated by immune response activity].

Abstract:

:The aim of this work was to estimate influence of activated immune response on hematopoiesis in vitro, using the experimental model of BCG immunized BALB/c mice and in patients with chronic immunoactivation: long-lasting infections, autoimmunity or malignancy. We correlated changes in long term bone marrow cultures (Dexter) and NBT reduction with appearance of anemia in patients and experimental model of immunization by BCG. Increased spontaneous NBT reduction pointed out role of macrophage activation in bone marrow stroma damage. Long-term bone marrow cultures showed reduced number of hematopoietic cells, with predomination of fibroblasts and loss of fat cells. This results correlated with anemia and leucocytosis with stimulated myelopoiesis in peripheral blood. Activation of immune response, or acting of any agent that directly changes extracellular matrix and cellularity of bone marrow, may result in microenviroment bone marrow damage that modify hematopoiesis.

journal_name

Srp Arh Celok Lek

authors

Vojinović J,Kamenov B,Najman S,Branković Lj,Dimitrijević H

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

28-31

eissn

0370-8179

issn

2406-0895

journal_volume

122 Suppl 1

pub_type

杂志文章
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    doi:

    authors: Belojević G,Jakovljević B,Stojanov V,Paunović K,Ilić J

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    doi:

    authors: Manojlović D,Stijelja B,Berger S,Sajinović D,Jovanović S

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  • [Subclinical disorders of left ventricular function in diabetics detected by echocardiography].

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    doi:

    authors: Visekruna T,Mijalković D,Djurić B,Pudar-Branković G

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    authors: Gujanica Z,Janković I,Jevtić D,Marković M,Marjanović B,Janković B

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  • [Wound infection after carotid artery endarterectomy caused by methicillin-resistant Staphylococcus aureus: case report].

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    journal_title:Srpski arhiv za celokupno lekarstvo

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  • [Beta-adrenergic blockers in congestive heart failure: pro et contra?].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Trifunović SL,Pavlović K

    更新日期:1992-06-01 00:00:00

  • [Applicability of visual-analogue scale in patients with orofacial ain].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Lončar J,Panić Z,Stojšin I,Savović S,Petrović B

    更新日期:2013-07-01 00:00:00

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Miljković D,Dzelebcjić J,Kostić N

    更新日期:1995-05-01 00:00:00

  • Urgent hybrid approach in treatment of the acute myocardial infarction complicated by the ventricular septal rupture.

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    pub_type: 杂志文章

    doi:10.2298/sarh1404226r

    authors: Radosavljević-Radovanović M,Radovanović N,Arandjelović A,Mitrović P,Usćumlić A,Stanković G

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  • Lymphoblastic lymphomas in children – A single-center experience from Serbia.

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Lazić J,Janić D,Krstovski N,Rodić P,Milošević G,Janković S,Brašanac D,Dokmanović L

    更新日期:2016-07-01 00:00:00

  • [Anniversaries of the Serbian Medical Society, 1952: 80 years since the founding of the Society--first results and confrontations].

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    pub_type: 历史文章,杂志文章

    doi:

    authors: Vuković Z

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  • [Surgical management of developmental disorder of the hip in older children by double osteotomy of the pelvis].

    abstract::Our results of surgery of developmental disorder of the hip (DDH) in older children and adolescents by using the combination of Selter's innominate osteotomy and osteotomy of the superior pubis ramus were presented in this paper, enclosing the period from 1993 to 1995. The study included 11 hips, i.e. 9 patients, aged...

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    pub_type: 杂志文章

    doi:10.2298/sarh04s1023b

    authors: Brdar R

    更新日期:2004-10-01 00:00:00

  • [Ancient Greek in modern language of medicine].

    abstract::In order to standardize language of medicine, it is essential to have a good command of ancient Greek and Latin. We cannot deny a huge impact of ancient Greek medicine on medical terminology. Compounds of Greek origin related to terms for organs, illnesses, inflammations, surgical procedures etc. have been listed as e...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0710606m

    authors: Marković V

    更新日期:2007-09-01 00:00:00

  • [Allergic complications of L-asparaginase therapy in children with acute lymphoblastic leukaemia].

    abstract:INTRODUCTION:L-asparaginase (L-ASP) is one of the most effective medications for the treatment of acute lymphoblastic leukaemia (ALL) in children, and allergic reactions to the therapy are considered the most significant side effects. OBJECTIVE:The aim of this study was to determine the prevalence and type of allergic...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1112749k

    authors: Konstantinidis N,Kolarović J,Kaćanski N,Vijatov-Djurić G,Konstantinidis G

    更新日期:2011-11-01 00:00:00

  • [Infected tibial nonunions--treatment by the Ilizarov method: multicentric study].

    abstract:INTRODUCTION:Associated bone tissue defect and infection, commonly result in non-healing, i.e., by the development of infected tibial nonunion. OBJECTIVE:The aim of the paper was to present experiences acquired in the treatment of this problem by the application of the Ilizarov method. METHODS:The analyses enrolled 1...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,多中心研究

    doi:10.2298/sarh1202065v

    authors: Vukašinović Z,Spasovski D,Vučetić Č,Jovanović V,Šešlija I,Živković Z

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  • Clinical features and endodontic treatment of two-rooted mandibular canines: report of four cases.

    abstract:INTRODUCTION:Predictable endodontic treatment depends on the dentist's knowledge about root canal morphology and its possible anatomic variations. The majority of mandibular canines have one root and root canal, but 15% may have two canals and a smaller number may have two distinct roots. The following clinical reports...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

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  • [Granulocytic sarcoma of the femur in a patient with acute megakaryoblastic leukaemia].

    abstract:INTRODUCTION:Granulocytic sarcoma, chloroma or myeloblastoma are observed in 3% to 7% of acute myeloid leukaemia and represents localized tumour composed of collection of immature leukaemic cells. It appears most frequently in patients with M2, M4 and M5 subtypes of acute myeloid leukaemia CASE OUTLINE:A 58-year-old f...

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  • [Intramural haematoma and penetrating aortic ulcer--outcome and treatment modalities: report of four cases].

    abstract:INTRODUCTION:Intramural haematoma (IMH) and penetrating aortic ulcers (PAU) are the frequent cause of acute aortic syndrome that is disclosed with a rising frequency due to the development of new diagnostic methods. Different symptoms contribute to clinical misdiagnosis, while changeable locations and unpersuasive diam...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1106380k

    authors: Končar I,Davidović L,Čolić M,Dragaš M,Ilić N,Menković N,Vučković M,Kalimanovska-Oštrić D,Cvetković S,Kostić D

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  • [Volunteer blood donors--relation between gender and motivation].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Andjelić D

    更新日期:1991-07-01 00:00:00

  • Development and evaluation of the nurse quality of communication with patient questionnaire.

    abstract:INTRODUCTION:Nurse/patient relationship as a complex interrelation or as an interaction of the factor patient and factor nurse has been a subject of a number of studies during the past ten years. Nurse/patient communication is a special entity, usually observed within a framework of the wider nurse/patient relationship...

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    更新日期:2010-01-01 00:00:00

  • [Characteristics of primary hyperparathyroidism in our country].

    abstract::Primary hyperparathyroidism (HPT) is rarely diagnosed in our country and when found, it is in the very late phase. Skeletal and renal forms of the disease are predominating, as it was in the developed couuntries thirty or forty years ago. Among 100 patients operated for HPT from 1980 to 1993, skeletal changes dominate...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Janković R,Diklić A

    更新日期:1995-01-01 00:00:00

  • [Maria Müller (1883-?) M.D., ophthalmologist: biographical notes].

    abstract::Maria Müller was one of the first female ophthalmologists in Serbia. Having researched the documents from several archives in Serbia-Belgrade, Novi Sad and Sremska Mitrovica, we were able to follow her life and work. Maria Müller was born in Budapest in 1883. From 1909 to 1919 she worked at the Budapest Hungarian Roya...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Litričin V

    更新日期:2012-01-01 00:00:00

  • Heterotopic pregnancy after in vitro fertilization and embryo transfer: a case report.

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    pub_type: 杂志文章

    doi:

    authors: Sparić R,Buzadzić S,Argirović R,Bratić D,Plećas D

    更新日期:2012-07-01 00:00:00

  • [Transitory hypothermia as early prognostic factor in term newborns with intrauterine growth retardation].

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    pub_type: 杂志文章

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  • Small bowel adenocarcinoma mimicking a large adrenal tumor.

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  • [Lupus nephritis--clinical and morfological correlation].

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    pub_type: 杂志文章

    doi:

    authors: Banković N,Blagojević R,Jovanović D,Sindjić M,Pavlović S,Stojković D,Djukanović Lj

    更新日期:1994-07-01 00:00:00

  • [Exercise-induced oxidative stress and antioxidant enzyme activity in type 2 diabetic patients with and without diastolic dysfunction and hypertension].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0910524m

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    更新日期:2009-09-01 00:00:00