Bisphosphonates and bisphosphonate induced osteonecrosis.

Abstract:

:Bisphosphonate-induced osteonecrosis of the jaws is the correct term for this real drug complication that most dental practitioners face. All nitrogen-containing bisphosphonates pose a risk, which is related to the route of administration, the potency of the bisphosphonate, and the duration of use. Although intravenous bisphosphonate-induced osteonecrosis of the jaws is mostly permanent, most cases can be prevented or managed if they develop, with only a few cases requiring resection for resolution. Oral bisphosphonate-induced osteonecrosis of the jaws also can be prevented with knowledge of the risk level related to the duration of use and the C-terminal telopeptide blood test results. Most cases can be resolved with a drug holiday either spontaneously or via straightforward débridement.

authors

Sawatari Y,Marx RE

doi

10.1016/j.coms.2007.07.003

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

487-98, v-vi

issue

4

eissn

1042-3699

issn

1558-1365

pii

S1042-3699(07)00050-7

journal_volume

19

pub_type

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