Abstract：
INTRODUCTION:Delayed ischemic deficit from vasospasm is a leading cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage. Although several treatment modalities have been used to reverse the deleterious effects of vasospasm, alternative therapies are needed, as conventional therapies are often ineffective or contraindicated. Intrathecal nicardipine has been suggested for the prevention of vasospasm. We report our clinical experience with intraventricular nicardipine for refractory vasospasm in eight patients in whom conventional therapies were ineffective, contraindicated, or technically not feasible. METHOD:Retrospective case series performed at a tertiary care university hospital. RESULTS:Eight patients (median Hunt-Hess grade = 2, median Fisher score = 4) with refractory vasospasm received intraventricular nicardipine (4 mg every 12 h) for a total of 5-17 days. One patient died in the intensive care unit. Seven patients had moderate to good outcomes with 6 being discharged to home (median Rankin Score = 2). Intraventricular nicardipine was well tolerated with minimal side effects. CONCLUSION:Our preliminary observations suggest that intraventricular nicardipine could be considered as a safe and effective treatment modality to treat vasospasm refractory to conventional management. A randomized, controlled trial to verify the efficacy and safety of intrathecal nicardipine in the prevention and treatment of cerebral vasospasm is warranted.
journal_name
Neurocrit Carejournal_title
Neurocritical careauthors
Goodson K,Lapointe M,Monroe T,Chalela JAdoi
10.1007/s12028-007-9017-zsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
247-52issue
2eissn
1541-6933issn
1556-0961journal_volume
8pub_type
杂志文章abstract：:An elevated platelet count may occur during care of neurology/neurosurgical patients and is usually due to reactive or secondary thrombocytosis (ST) caused by inflammation or infection. Primary (clonal) thrombocythemia or essential thrombocythemia associated with myeloproliferative disorders is usually known before or...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-008-9076-9
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Infection in the intensive care unit (ICU) empirically requires broad-spectrum antibiotics. Imipenem/cilastatin, often reserved for more serious hospital-acquired infections, is thought to be associated with a higher risk of seizures than other penicillins and carbapenems. We sought to evaluate the safety of...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-008-9170-z
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Rapid diagnosis and proper management of intracerebral hemorrhage (ICH) play a crucial role in the outcome. Prediction of the outcome with a high degree of accuracy based on admission data including imaging information can potentially influence clinical decision-making practice. METHODS:We conducted a retro...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00783-8
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Unilateral anterior spinal artery (ASA) occlusion resulting in bilateral medullary pyramidal (BMP) infarction is a rare and devastating stroke subtype. We present two cases highlighting the diagnostic and clinical challenges of BMP infarction. METHODS:Case reports and literature review. RESULTS:A 57-year-o...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-017-0406-7
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Sedation and therapeutic hypothermia (TH) delay neurological responses and might reduce the accuracy of clinical examination to predict outcome after cardiac arrest (CA). We examined the accuracy of quantitative pupillary light reactivity (PLR), using an automated infrared pupillometry, to predict outcome of...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-014-9981-z
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND/PURPOSE:Blood type has become an increasingly recognized risk factor for coagulopathy. We explored the association between blood type and hematoma expansion (HE) after intracerebral hemorrhage (ICH). METHODS:Spontaneous ICH patients prospectively enrolled in an ongoing ICH cohort study at Columbia Universit...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0655-0
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Status, refractory status and super refractory status epilepticus are common neurologic emergencies. The objective of this study is to investigate the feasibility, safety and effectiveness of a ketogenic diet (KD) for refractory status epilepticus (RSE) in adults in the intensive care unit (ICU). METHODS:We...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0653-2
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:This prospective study of an innovative non-invasive ultrasonic cerebrovascular autoregulation (CA) monitoring method is based on real-time measurements of intracranial blood volume (IBV) reactions following changes in arterial blood pressure. In this study, we aimed to determine the clinical applicability o...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0569-x
更新日期：2019-02-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:5:3:206
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:To describe a case of auto-immune encephalitis in an adolescent with favorable outcome despite prolonged status epilepticus. METHODS:A 17 year old Asian man without previous medical history developed alteration of consciousness and partial seizures. The diagnosis of anti-N-methyl-D-aspartate receptor enceph...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-012-9788-8
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Impaired cerebrovascular reactivity (CR) has been reported to be associated with adverse outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, CR may be determined using different paradigms and it is unclear, which measurement method most suitable reflects the clinical course or is abl...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-009-9287-8
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To propose a novel definition for hydrocephalus growth and to further describe the association between hydrocephalus growth and poor outcome among patients with intracerebral hemorrhage (ICH). METHODS:We analyzed consecutive patients who presented within 6 h after ICH ictus between July 2011 and ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-020-01140-w
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:Intrahospital transport is associated with a high rate of complications. Investigations of this problem using neuromonitoring remain scarce. METHODS:This is a monocentric, prospective observational study. Patients with severe brain diseases and intracranial pressure (ICP) monitoring were included. Continuou...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-016-0274-6
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:An alternation of sympathetic and vagal nervous activity has been suggested to be one possible mechanism of neurogenic pulmonary edema (NPE) in patients with subarachnoid hemorrhage (SAH). The study aimed to explore if sympathovagal modulation assessed by frequency domains of heart rate variability (HRV) is ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-015-0237-3
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:Spinal cord ischemia and stroke are recognized complications of descending thoracic (DTA) and thoracoabdominal aortic (TAA) operations. However, there are limited data available on outcomes since the advent of thoracic endovascular aortic repair (TEVAR). METHODS:We reviewed charts from consecutive patient...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9104-9
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Hematoma expansion (HE) occurs in approximately one-third of patients with intracerebral hemorrhage (ICH) and is known to be a strong predictor of neurological deterioration as well as poor functional outcome. This study aims to externally validate three risk prediction models of HE (PREDICT, 9-point, and BR...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0631-8
更新日期：2019-04-01 00:00:00
abstract：: ...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-018-0585-x
更新日期：2019-04-01 00:00:00
abstract：:In the original article, Figure 5 has incorrect EEG images and the corrected version is shown below. ...
journal_title：Neurocritical care
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12028-020-00981-9
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Takotsubo syndrome is a reversible neuromyocardial failure that has been thought to be related to an acute catecholamine toxicity of the myocardium brought upon by a stressful event. The neurocritical care unit population is particularly vulnerable for this condition given the acute presentation of neurologi...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-008-9075-x
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The objectives of this study were to determine effects of severe traumatic brain injury (TBI) on cerebrospinal fluid (CSF) concentrations of myelin basic protein (MBP) and to assess relationships between clinical variables and CSF MBP concentrations. METHODS:We measured serial CSF MBP concentrations in chil...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-012-9767-0
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Syringohydromyelia associated with supratentorial space-occupying lesion has rarely been reported. We present a 28-year-old woman was admitted to the hospital with head and neck pain. Upon examination, there was only left central facial paralisia, with no evidence of papilledema. METHODS AND RESULTS:Crani...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1385/NCC:2:1:051
更新日期：2005-01-01 00:00:00
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journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00795-4
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:There is no uniform definition for cerebral microdialysis (CMD) probe location with respect to focal brain lesions, and the impact of CMD-probe location on measured molecule concentrations is unclear. METHODS:We retrospectively analyzed data of 51 consecutive subarachnoid hemorrhage patients with CMD-monito...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00713-8
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Plateau waves are common in traumatic brain injury. They constitute abrupt increases of intracranial pressure (ICP) above 40 mmHg associated with a decrease in cerebral perfusion pressure (CPP). The aim of this study was to describe plateau waves characteristics with multimodal brain monitoring in head injur...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9918-y
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Neurogenic pulmonary edema (NPE) is an acute life-threatening complication associated with many forms of central nervous system injury. NPE usually appears within minutes to hours after injury and has a high mortality rate if not recognized and treated appropriately. Lung ultrasound quickly provides at the b...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-013-9828-z
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Stress-induced hyperglycemia (SIH) is the relative transient increase in glucose during a critical illness such as intracerebral hemorrhage (ICH) and is likely to play an important role in the pathogenesis of remote diffusion-weighted imaging (DWI) lesion (R-DWIL) in primary ICH. We sought to det...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-019-00747-y
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:Recent and on going clinical research trials may indicate that the incidence of vasospasm is less in patients treated with lumbar drains following SAH than with patients treated with external ventricular drainage (EVD) alone. These studies have sparked interest in the more aggressive use of LDs in patients...
journal_title：Neurocritical care
pub_type： 杂志文章
doi：10.1007/s12028-007-0047-3
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Physiological reactions of the stress hormone cortisol include hyperglycemia, hypertension, and endothelium dysfunction. In patients with aneurysmal subarachnoid hemorrhage (SAH), hyperglycemia, hypertension, and endothelium dysfunction are associated with the occurrence of delayed cerebral ischemia (DCI). T...
journal_title：Neurocritical care
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12028-010-9331-8
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Apnea testing is an essential step in the clinical diagnosis of brain death. Current international guidelines recommend placement of an oxygen (O2) insufflation catheter into the endotracheal tube to prevent hypoxemia, but use of a continuous positive airway pressure (CPAP) valve may be more effective at lim...
journal_title：Neurocritical care
pub_type： 杂志文章,多中心研究
doi：10.1007/s12028-017-0380-0
更新日期：2017-08-01 00:00:00
abstract：:Traumatic brain injury (TBI) was chosen as an Emergency Neurological Life Support topic due to its frequency, the impact of early intervention on outcomes for patients with TBI, and the need for an organized approach to the care of such patients within the emergency setting. This protocol was designed to enumerate the...
journal_title：Neurocritical care
pub_type： 杂志文章,评审
doi：10.1007/s12028-012-9760-7
更新日期：2012-09-01 00:00:00
