Effects of metabolic rate on protein evolution.

Abstract:

:Since the modern evolutionary synthesis was first proposed early in the twentieth century, attention has focused on assessing the relative contribution of mutation versus natural selection on protein evolution. Here we test a model that yields general quantitative predictions on rates of protein evolution by combining principles of individual energetics with Kimura's neutral theory. The model successfully predicts much of the heterogeneity in rates of protein evolution for diverse eukaryotes (i.e. fishes, amphibians, reptiles, birds, mammals) from different thermal environments. Data also show that the ratio of non-synonymous to synonymous nucleotide substitution is independent of body size, and thus presumably of effective population size. These findings indicate that rates of protein evolution are largely controlled by mutation rates, which in turn are strongly influenced by individual metabolic rate.

journal_name

Biol Lett

journal_title

Biology letters

authors

Gillooly JF,McCoy MW,Allen AP

doi

10.1098/rsbl.2007.0403

subject

Has Abstract

pub_date

2007-12-22 00:00:00

pages

655-9

issue

6

eissn

1744-9561

issn

1744-957X

pii

Q7283GJ033VM1051

journal_volume

3

pub_type

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