当前位置： SCI文献检索 > SLEEP MEDICINE期刊下所有文献 > Cardiac function after CPAP therapy in patients with chronic heart failure and sleep apnea: a multicenter study.

Cardiac function after CPAP therapy in patients with chronic heart failure and sleep apnea: a multicenter study.

Abstract：

BACKGROUND AND PURPOSE:Continuous positive airway pressure (CPAP) is an effective treatment for sleep apnea (SA), although the evidence for improving chronic heart failure (CHF) is inconclusive. Our aim was to evaluate the effect of CPAP treatment on the left ventricle ejection fraction (LVEF) among other cardiological variables in a randomized, multicenter, placebo (sham-CPAP)-controlled study. METHODS:After the selection procedure, 60 patients with CHF with LVEF<45% and SA with an apnea-hypopnea index (AHI)>10/h were evaluated at baseline, and after 3 months of treatment with optimal CPAP or sham-CPAP. The assessment was based on the LVEF, hypertension, daytime sleepiness (Epworth sleepiness scale [ESS]), quality of life (SF-36), New York Heart Scale (NYHA score), dyspnea (by using the Borg scale) and exercise tolerance (6-min walk test). RESULTS:The mean AHI was normalized in the optimal CPAP group but not in the sham-CPAP group. The LVEF showed a significant improvement in the group of patients treated with CPAP (2.5; 95% CI: 0.6 to 4.3), which was not observed in the sham-CPAP group (0.0; 95% CI: -2.1 to 2.1). However, the change in the LVEF from baseline to 3 months was not significantly greater in the whole group (obstructive and Cheyne-Stokes events) treated with CPAP than in the control group (p: 0.07). In patients with only obstructive sleep apnea (OSA), who account for 83% of the total population, there was a significant improvement in the LVEF in the group of patients treated with CPAP but no such improvement in the sham-CPAP group. In this OSA group, the change in the LVEF from baseline to 3 months was significantly greater in the group treated with CPAP than in the sham-CPAP group (p: 0.03). The other variables studied were not modified. When the patients were divided according to the severity of the LVEF (a LVEF cut-off of 30%), improvement was observed in those with a LVEF>30. No changes were found in the other cardiological variables. CONCLUSIONS:CPAP therapy proved to be useful in patients with associated sleep-disordered breathing and CHF. The improvement was more marked in patients with a LVEF>30%. However, the increased LVEF in the CPAP group was not accompanied by changes in the other cardiological variables.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Egea CJ,Aizpuru F,Pinto JA,Ayuela JM,Ballester E,Zamarrón C,Sojo A,Montserrat JM,Barbe F,Alonso-Gomez AM,Rubio R,Lobo JL,Duran-Cantolla J,Zorrilla V,Nuñez R,Cortés J,Jiménez A,Cifrián J,Ortega M,Carpizo R,Sánchez

doi

10.1016/j.sleep.2007.06.018

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

660-6

issue

eissn

1389-9457

issn

1878-5506

pii

S1389-9457(07)00294-8

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

在线工具

Cardiac function after CPAP therapy in patients with chronic heart failure and sleep apnea: a multicenter study.