Abstract:
:We have developed an indirect microhemagglutination test (IMHA) for detecting antibodies to Borrelia burgdorferi using formalin-fixed chicken erythrocytes sensitized with a sonicated extract of the bacteria. The specificity of IMHA for Lyme disease was compared with that of a conventional indirect immunoperoxidase technique (IP) using sera from the patients with syphilis, randomly-chosen outpatients unrelated to Lyme disease, and from normal individuals. The IMHA was more specific than IP, giving little cross-reaction with syphilis. The IMHA also gave little background reactions with the sera of individuals unrelated to Lyme disease or syphilis. Therefore, the IMHA could be a useful test for the serodiagnosis of Lyme disease.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Fujita H,Sato T,Ohara Y,Homma Mdoi
10.1111/j.1348-0421.1991.tb01590.xsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
589-92issue
7eissn
0385-5600issn
1348-0421journal_volume
35pub_type
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