Abstract:
OBJECTIVE:To examine age-related changes in the neural systems for reading in nonimpaired and dyslexic children and adolescents. METHODS:Functional magnetic resonance imaging was used to study age-related changes in the neural systems for reading in a cross-sectional sample of 232 right-handed children 7 to 18 years of age (113 dyslexic readers and 119 nonimpaired readers) as they read pseudowords. RESULTS:In nonimpaired readers, systems in the left anterior lateral occipitotemporal area developed with age, whereas systems in the right superior and middle frontal regions decreased. In contrast, in dyslexic readers, systems in the left posterior medial occipitotemporal regions developed with age. Older nonimpaired readers were left lateralized in the anterior lateral occipitotemporal area; there was no difference in asymmetry between younger and older dyslexic readers. INTERPRETATION:These findings offer a possible neurobiological explanation for the differences in reading acquisition between dyslexic and nonimpaired readers and provide further evidence of the critical role of the left occipitotemporal region in the development of reading.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Shaywitz BA,Skudlarski P,Holahan JM,Marchione KE,Constable RT,Fulbright RK,Zelterman D,Lacadie C,Shaywitz SEdoi
10.1002/ana.21093subject
Has Abstractpub_date
2007-04-01 00:00:00pages
363-70issue
4eissn
0364-5134issn
1531-8249journal_volume
61pub_type
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410310512
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doi:10.1002/ana.22102
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410420409
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abstract::We recently reported that systemic administration of a proteasome inhibitor induced a progressive levodopa-responsive, bradykinetic syndrome in rats with imaging, pathological, and biochemical features that strikingly resemble what is found in PD. This model has the potential to be a useful tool for studying the mecha...
journal_title:Annals of neurology
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doi:10.1002/ana.20936
更新日期:2006-08-01 00:00:00
abstract::Charcot-Marie-Tooth (CMT) neuropathies are inherited neuromuscular disorders caused by a length-dependent neurodegeneration of peripheral nerves. More than 900 mutations in 60 different genes are causative of the neuropathy. Despite significant progress in therapeutic strategies, the disease remains incurable. The inc...
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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doi:10.1002/ana.410340118
更新日期:1993-07-01 00:00:00
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journal_title:Annals of neurology
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更新日期:2002-01-01 00:00:00
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journal_title:Annals of neurology
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更新日期:1996-12-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410020414
更新日期:1977-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-04-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410390218
更新日期:1996-02-01 00:00:00
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doi:10.1002/ana.22164
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410020603
更新日期:1977-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.22631
更新日期:2012-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410080404
更新日期:1980-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410020413
更新日期:1977-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章,评审
doi:10.1002/ana.410350707
更新日期:1994-01-01 00:00:00
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doi:10.1002/ana.24199
更新日期:2014-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/ana.410360728
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.24946
更新日期:2017-06-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.23862
更新日期:2013-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410400310
更新日期:1996-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410090209
更新日期:1981-02-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410090407
更新日期:1981-04-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410420517
更新日期:1997-11-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1980-04-01 00:00:00