Abstract:
STUDY DESIGN:An experimental animal study. OBJECTIVE:To study if antitumor necrosis factor-alpha (TNF-alpha) antibody, which is administered at different times, reduces the pain behavior induced by application of nucleus pulposus (NP) to the nerve root. SUMMARY OF BACKGROUND DATA:Treatment with TNF-alpha inhibitor reduces the pain-related behavior induced by epidural application of NP in rats. METHODS:Left L5 partial laminectomy was performed and NP was applied to the L5 nerve root in 24 rats. The rats were divided into 4 groups. In 3 groups, anti-rat TNF-alpha antibody was intravenously administered immediately after, or 6 or 20 days after NP application. The fourth group was not treated with anti-rat TNF-alpha antibody (untreated rats). The withdrawal threshold of the plantar surface was determined 1 day before up through 28 days after NP application. RESULTS:The withdrawal threshold of rats that had been treated with anti-rat TNF-alpha antibody immediately after or 6 days after, but not 20 days after, NP application, was significantly higher than that of the untreated rats. CONCLUSIONS:Anti-TNF-alpha antibody reduced allodynia only when it was administered soon after the onset of allodynia. Late administration of anti-TNF-alpha antibody did not have an antiallodynic effect.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Sasaki N,Kikuchi S,Konno S,Sekiguchi M,Watanabe Kdoi
10.1097/01.brs.0000255097.18246.bcsubject
Has Abstractpub_date
2007-02-15 00:00:00pages
413-6issue
4eissn
0362-2436issn
1528-1159pii
00007632-200702150-00005journal_volume
32pub_type
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