Abstract:
:We examined the mechanism of amiloride-sensitive Na(+) channels (ENaC) activated by fANP in epithelial cells of frog urinary bladder by using a cell-attached patch-clamp technique. ENaC activities in the epithelial cells were significantly increased following administration of both 10(-9)M fANP and 10(-5)M 8-Br-cGMP. Both fANP and 8-Br-cGMP, however, failed to activate the ENaC in the presence of 10(-6)M amiloride. In addition, 8-Br-cGMP failed to activate the ENaC in the presence of a PKA inhibitor, KT-5720. In the next experiment, we measured both cGMP and cAMP production levels after treatment of fANP on the frog urinary bladder cells. Frog ANP significantly increased cGMP production, but not the cAMP production. Taken together, these results suggest that fANP activates ENaC through increases in cGMP production and activation of PKA.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Yamada T,Matsuda K,Uchiyama Mdoi
10.1016/j.ygcen.2006.11.003subject
Has Abstractpub_date
2007-06-01 00:00:00pages
286-8issue
2-3eissn
0016-6480issn
1095-6840pii
S0016-6480(06)00338-8journal_volume
152pub_type
杂志文章abstract::In dairy cows, heat stress depresses appetite, leading to decreased food intake, a negative energy balance, and modifies ghrelin levels. Ghrelin is a gut-brain peptide with two major forms: acylated, with an O-n-octanoylated serine in position 3, and nonacylated. To date, the effect of heat stress and estrous cycle on...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2016.06.006
更新日期:2016-09-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(91)90145-v
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journal_title:General and comparative endocrinology
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(92)90070-z
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.08.002
更新日期:2008-10-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2006.08.005
更新日期:2007-01-15 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.2000.7582
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90106-0
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2004.05.010
更新日期:2004-09-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(86)90101-2
更新日期:1986-04-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1996.6802
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90155-2
更新日期:1984-06-01 00:00:00
abstract::Using antibodies to the amino-terminal region of human parathyroid hormone-related protein (PTHrP) we have demonstrated PTHrP immunoreactivity in pituitaries and plasma of the sea bream (Sparus aurata). Pituitary cells at two distinct locations contained immunodetectable PTHrP; an anterior group in the rostral pars di...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1156
更新日期:1993-11-01 00:00:00
abstract::Ecdysis, or the shedding of the old cuticle, depends on coordinated stereotyped behaviors, regulated by a number of neuropeptides. In the hornworm, Manduca sexta, two neuropeptides interact, namely ecdysis-triggering hormone (ETH) and eclosion hormone. We looked at the effects of ETH in vivo and in vitro, on the brain...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2009.08.008
更新日期:2010-03-01 00:00:00
abstract::Ghrelin, a peptide hormone produced by the stomach in mammals, stimulates growth hormone release and food intake. Recently, ghrelin was identified and characterized in chicken proventriculus and shown to stimulate growth hormone release but inhibit feed intake. The purpose of this work was to identify and further char...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2005.09.013
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abstract::PCB 77 is a dioxin-like PCB that has been shown to reduce circulating thyroid hormone (TH) levels. This may be an important factor contributing to its neurotoxicity, since THs are essential for normal brain development. In this study, we investigated the changes in TH activating and inactivating iodothyronine deiodina...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1998.7076
更新日期:1998-06-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.07.018
更新日期:2008-09-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(87)90188-2
更新日期:1987-09-01 00:00:00
abstract::This set of experiments investigated the role of protein kinase-C (PKC) as a second messenger in vasoactive intestinal peptide (VIP)-stimulated prolactin (PRL) secretion and PRL mRNA abundance. Dispersed anterior pituitary cells (5 x 10(5) or 10(6) cells/tube) were isolated from laying turkeys and incubated in 1.0 ml ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1995.1112
更新日期:1995-09-01 00:00:00
abstract::Wrasse species exhibit a definite daily rhythm in locomotor activity and bury themselves in the sand at the bottom of the ocean at night. It remains unclear how their behavior in locomotor activity is endogenously regulated. The aim of the present study was to clarify the involvement of melatonin and clock genes (Per1...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.01.007
更新日期:2012-05-15 00:00:00
abstract::Serum prolactin (PRL) and luteinizing hormone (LH) levels from mature female turkeys were determined following ovariectomy and daily subcutaneous injections for 4 or 9 days of 0.002-2.0 mg/kg estradiol benzoate (EB), 0.05-2.0 mg/kg progesterone (P), or their combinations. Serum PRL levels were increased (P less than 0...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.02.013
更新日期:2008-05-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1996.6857
更新日期:1997-04-01 00:00:00
abstract::Female American tree sparrows (Spizella arborea) were injected with Na131I before, at, or after the onset of photostimulation in order to study the effect of time of thyroidectomy on three components of seasonality: thyroid-dependent photoperiodic ovarian growth, photorefractoriness, and postnuptial (prebasic) molt. T...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1999.7267
更新日期:1999-06-01 00:00:00
abstract::The effects of fasting and feeding on the brain expression of orexin (OX), tyrosine hydroxylase (TH), peptide Y (PY) and cholecystokinin (CCK) were examined in the blind cavefish Astyanax fasciatus mexicanus. A 10-days fasting period induced increases in both OX and TH brain mRNA expression but had no effect on PYY an...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.12.011
更新日期:2013-03-01 00:00:00