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Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.

Abstract：

:A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Koehler K,Gordon S,Brandt P,Carlsson B,Bäcksbro-Saeidi A,Apelqvist T,Agback P,Grover GJ,Nelson W,Grynfarb M,Färnegårdh M,Rehnmark S,Malm J

doi

10.1021/jm060521i

subject

Has Abstract

pub_date

2006-11-16 00:00:00

pages

6635-7

issue

23

eissn

0022-2623

issn

1520-4804

journal_volume

49

pub_type

杂志文章

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