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The effect of cartilage-derived morphogenetic protein 2 on initial healing of a rotator cuff defect in a rat model.

Abstract：

:This animal study evaluated the healing of supraspinatus tendon tears by use of a cartilage-derived morphogenetic protein 2 growth factor (CDMP-2) delivered to the repair. Forty-eight rats had bilateral, surgically created complete tears repaired by sutures with the growth factor introduced on one side. They were killed at 2, 3, 4, and 6 weeks, and the strength of the repairs was determined and histologic analysis performed. At 4 and 6 weeks, the CDMP-2-treated repairs were significantly stronger than the untreated repairs and histologic analysis showed more organized healing. The use of growth factors introduced at the time of rotator cuff repair might promote more rapid healing and subsequent, rapid patient rehabilitation.

journal_name

J Shoulder Elbow Surg

journal_title

Journal of shoulder and elbow surgery

authors

Murray DH,Kubiak EN,Jazrawi LM,Araghi A,Kummer F,Loebenberg MI,Zuckerman JD

doi

10.1016/j.jse.2006.07.002

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

251-4

issue

2

eissn

1058-2746

issn

1532-6500

pii

S1058-2746(06)00206-0

journal_volume

16

pub_type

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