Abstract:
:The heterogeneous childhood limb-girdle muscular dystrophies have originally been defined as a group of autosomal recessive and dominant diseases with progressive weakness and wasting of shoulder and pelvic-girdle muscles. Over the last 12 years, the underlying genetic defects for many of the diseases have been identified and insight into pathomechanisms of disease has been gained. At the same time, improved diagnostic techniques have allowed to extend the phenotypic spectrum for many of these devastating conditions, which showed that clinical symptoms and pathological findings are not restricted to skeletal muscles. Childhood limb-girdle muscular dystrophies are systemic diseases that often affect the musculoskeletal, respiratory, and cardiovascular system and that can go along with central nervous system involvement and gastrointestinal symptoms. The systemic nature of the diseases requires adequate management strategies that improve symptoms, longevity, and quality of life of the patients. As we are entering an era of translational research the need for precise molecular diagnoses, a thorough understanding of the natural history of the diseases and guidelines for standardized assessments of the patients become even more relevant. In this review, the best characterized childhood limb-girdle muscular dystrophies are discussed and their management aspects highlighted.
journal_name
Semin Pediatr Neuroljournal_title
Seminars in pediatric neurologyauthors
Straub V,Bushby Kdoi
10.1016/j.spen.2006.06.006subject
Has Abstractpub_date
2006-06-01 00:00:00pages
104-14issue
2eissn
1071-9091issn
1558-0776pii
S1071-9091(06)00096-9journal_volume
13pub_type
杂志文章,评审abstract::Velocardiofacial syndrome, also called Shprintzen syndrome or DiGeorge sequence, is one of the most common genetic disorders in humans. Caused by a microdeletion on chromosome 22, it manifests in a remarkable variety of symptoms in multiple systems. The most frequent anomalies involve palatal function, facial features...
journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
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更新日期:1995-09-01 00:00:00
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
doi:10.1016/j.spen.2008.05.003
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
doi:10.1016/j.spen.2004.01.004
更新日期:2004-03-01 00:00:00
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章
doi:10.1053/spen.2002.35499
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
doi:10.1016/j.spen.2015.11.001
更新日期:2015-12-01 00:00:00
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.spen.2011.05.003
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.spen.2011.05.006
更新日期:2011-06-01 00:00:00
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
pub_type: 杂志文章,评审
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journal_title:Seminars in pediatric neurology
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journal_title:Seminars in pediatric neurology
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更新日期:2003-12-01 00:00:00
abstract::Training in child neurology requires formal training in other aspects of pediatrics. This pediatrics training affords the ability to obtain a developmentally appropriate history and physical examination at all stages of childhood and adolescence and to provide anticipatory guidance to children and families of all deve...
journal_title:Seminars in pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.spen.2011.05.007
更新日期:2011-06-01 00:00:00
abstract::Astrocytes have long been forgotten entities in our quest to understand brain function. Over the last few decades, there has been an exponential increase in our knowledge of central nervous system (CNS) function, and, consequently, astrocytes have emerged as key figures in CNS physiology and disease. Indeed, several p...
journal_title:Seminars in pediatric neurology
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doi:10.1016/j.spen.2013.10.003
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