Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions.

abstract：PURPOSE:The aims of the present study were to evaluate the use of drugs with anticholinergic properties in elderly patients and to identify risk factors that increase the patient's chance of being given such medications. METHODS:The study was performed on a sample of 1636 patients aged ≥65 years hospitalised during th...

journal_title：Pharmacoepidemiology and drug safety

authors： Wawruch M,Macugova A,Kostkova L,Luha J,Dukat A,Murin J,Drobna V,Wilton L,Kuzelova M

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Quantitative benefit-risk (B-R) assessments are used to characterize treatment by combining key benefits and risks into a single metric but have historically been done for the "average" patient. Our aim was to conduct an individualized assessment for the oral antiplatelet vorapaxar by combining trial and real-w...

journal_title：Pharmacoepidemiology and drug safety

authors： Pinto CA,Tervonen T,Marsh K,Lambrelli D,Schultze A,Tershakovec A,Hyacinthe J,Prawitz T,Hammad TA

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Pharmacoepidemiologic studies of acute effects of episodic exposures often must control for many time-dependent confounders. Marginal structural models permit this and provide unbiased estimates when confounders are on the causal pathway. However, if causal pathway confounding is minimal, analyses with time-dep...

journal_title：Pharmacoepidemiology and drug safety

authors： Ray WA,Liu Q,Shepherd BE

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To examine the association between use of methylphenidate and the risk for valvular heart disease (VHD) in the Spanish primary care database BIFAP. METHODS:Case-control study nested in a cohort of patients aged 5 to 25 years between 2002 and 2014, based in a general practice research database. Cases were peopl...

journal_title：Pharmacoepidemiology and drug safety

authors： Saiz LC,Gil M,Alonso A,Erviti J,Garjón J,Martínez M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The absence of agreed competencies in pharmacovigilance and patient risk management is a key factor hindering the development of training and a curriculum in these interrelated disciplines. If competencies were to be developed, they could be tailored to the different roles and responsibilities of the various st...

journal_title：Pharmacoepidemiology and drug safety

authors： Edwards B,Tilson HH,West SL

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Fear of discontinuing concomitant anti-epileptic drugs (AEDs) may lead to potentially unnecessary and perhaps unsafe polypharmacy. The effect of withdrawing concomitant AEDs on epilepsy control was therefore studied in long-term users of levetiracetam. METHODS:The EULEV cohort followed patients initiating leve...

journal_title：Pharmacoepidemiology and drug safety

authors： Droz-Perroteau C,Marchal C,Dureau-Pournin C,Lassalle R,Jové J,Robinson P,Lavernhe G,Vespignani H,Moore N,Fourrier-Réglat A,Eulev Study Group.

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To evaluate the impact of 2 policy changes on quetiapine dispensing in Australia: removal of prior authorisation for prescribing (policy 1: July 2007) and removal of repeat prescriptions for 25-mg quetiapine (policy 2: January 2014). METHODS:We performed an interrupted time series analysis using Pharmaceutical...

journal_title：Pharmacoepidemiology and drug safety

authors： Brett J,Schaffer A,Dobbins T,Buckley NA,Pearson SA

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:We aim to derive an internationally applicable data set to improve prescription safety of psychiatric drugs. METHODS:We performed an in-depth analysis of the concordance of prescribing information of 10 key psychiatric drugs across four major drug markets with regard to indications, warnings and precautions, a...

journal_title：Pharmacoepidemiology and drug safety

authors： Pfistermeister B,Schenk C,Kornhuber J,Bürkle T,Fromm MF,Maas R

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Antiepileptic drugs (AEDs) are also prescribed for therapeutic indications other than epilepsy (EPI), namely, psychiatric disorders (PSY). Our aim was to develop an algorithm able to distinguish between EPI and PSY among childbearing age women based on differences in AED exposure in these patient groups. ME...

journal_title：Pharmacoepidemiology and drug safety

authors： Naldi I,Piccinni C,Mostacci B,Renzini J,Accetta G,Bisulli F,Tappatà M,Piazza A,Pagano P,Bianchi S,D'Alessandro R,Tinuper P,Poluzzi E,ESPEA (Emilia-Romagna Study on Pregnancy and Exposure to Antiepileptic drugs) Group.

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:The aim of the present study was to determine whether community pharmacists recommend appropriate medications and give valid information to pregnant women. METHODS:A total of 163 community pharmacists randomly selected in the Midi-Pyrénées area were interviewed by means of an open questionnaire. Ten scenarios ...

journal_title：Pharmacoepidemiology and drug safety

authors： Damase-Michel C,Vié C,Lacroix I,Lapeyre-Mestre M,Montastruc JL

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To conduct a systematic review of current evidence regarding the use of health information technology (HIT) interventions to improve drug monitoring in ambulatory care. METHODS:We searched PubMed, CINAHL, the Cochrane Library, and other computerized databases from 1 January 1998 to 30 June 2008 using the key w...

journal_title：Pharmacoepidemiology and drug safety

authors： Hayward GL,Parnes AJ,Simon SR

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the prevalence of potential drug-drug interactions (DDIs) in hospitalised patients in correlation with patient's age and number of drugs prescribed and to determine the prevalence of inappropriate drugs prescribed to elderly patients. METHODS:Drugs prescribed during ...

journal_title：Pharmacoepidemiology and drug safety

authors： Radosević N,Gantumur M,Vlahović-Palcevski V

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Observational pharmacoepidemiological studies can provide valuable information on the effectiveness or safety of interventions in the real world, but one major challenge is the existence of unmeasured confounder(s). While many analytical methods have been developed for dealing with this challenge, they appear u...

journal_title：Pharmacoepidemiology and drug safety

authors： Zhang X,Faries DE,Li H,Stamey JD,Imbens GW

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication. METHODS:We performed a cohort study with a nested case-control analysis using the General Practitioner Research D...

journal_title：Pharmacoepidemiology and drug safety

authors： González-Pérez A,Ronquist G,García Rodríguez LA

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:During the past two decades, many novel immunosuppressive drugs have been approved for transplant recipients. Trends in the use of maintenance immunosuppressants after liver transplantation in Asia are unclear. Thus, we aimed to analyze the prescription trends in maintenance immunosuppressive drugs among liver ...

journal_title：Pharmacoepidemiology and drug safety

authors： Huang YY,Hsu CC,Chou CL,Loong CC,Wu MS,Chou YC

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:De-implementation of low-value services among patients with limited life expectancy is challenging. Robust mortality prediction models using routinely collected health care data can enhance health care stakeholders' ability to identify populations with limited life expectancy. We developed and validated a claim...

journal_title：Pharmacoepidemiology and drug safety

authors： Lund JL,Kuo TM,Brookhart MA,Meyer AM,Dalton AF,Kistler CE,Wheeler SB,Lewis CL

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To determine the effectiveness of quality circles on prescribing patterns of primary care physicians in Germany and to explore the influence of specific factors on changes. METHODS:Three large non-randomised comparative studies were performed in primary care in Germany, with baseline measurements in 2001 and f...

journal_title：Pharmacoepidemiology and drug safety

authors： Wensing M,Broge B,Riens B,Kaufmann-Kolle P,Akkermans R,Grol R,Szecsenyi J

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Type 2 diabetes is associated with increased cardiovascular risk. The comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in reducing risk of cardiovascular disease in real-world settings is unknown. METHODS:A retrospective database analysis was performed using a large m...

journal_title：Pharmacoepidemiology and drug safety

authors： Suh HS,Hay JW,Johnson KA,Doctor JN

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Because health insurance claims lack clinical information, comparative effectiveness research studies that rely on these data may be challenging to interpret and may result in biased inference. We conducted an exploratory study to determine if medical information contained in patient charts could offer clinical...

journal_title：Pharmacoepidemiology and drug safety

authors： Croghan TW,Esposito D,Daniel G,Wahl P,Stoto MA

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:This study mainly aimed at describing the prevalence of psychotropic medication consumption in the Spanish elderly population between the years 1993 and 2003. METHODS:Descriptive, cross-sectional study covering the Spanish population aged 65 years and over, using data drawn from the 1993 and 2003 Spanish Natio...

journal_title：Pharmacoepidemiology and drug safety

authors： Carrasco-Garrido P,Jiménez-García R,Astasio-Arbiza P,Ortega-Molina P,de Miguel AG

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Despite numerous clinical guidelines on asthma management, patients often receive suboptimal drug therapy. This study identified patients who received suboptimal regimens according to the National Heart, Lung and Blood Institute (NHLBI) Guidelines for the Diagnosis and Management of Asthma in a complete popu...

journal_title：Pharmacoepidemiology and drug safety

authors： Zhang T,Smith MA,Camp PG,Carleton BC

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:Patients initiating warfarin therapy generally experience a dose-titration period of weeks to months, during which time they are at higher risk of both thromboembolic and bleeding events. Accurate prediction of prolonged dose titration could help clinicians determine which patients might be better treated by al...

journal_title：Pharmacoepidemiology and drug safety

authors： Finkelman BS,French B,Bershaw L,Brensinger CM,Streiff MB,Epstein AE,Kimmel SE

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:In post-marketing drug safety surveillance, data mining can potentially detect rare but serious adverse events. Assessing an entire collection of drug-event pairs is traditionally performed on a predefined level of granularity. It is unknown a priori whether a drug causes a very specific or a set of related adv...

journal_title：Pharmacoepidemiology and drug safety

authors： Kulldorff M,Dashevsky I,Avery TR,Chan AK,Davis RL,Graham D,Platt R,Andrade SE,Boudreau D,Gunter MJ,Herrinton LJ,Pawloski PA,Raebel MA,Roblin D,Brown JS

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Confounding, a concern in nonexperimental research using administrative claims, is nearly ubiquitous in claims-based pharmacoepidemiology studies. A fixed-length look-back window for assessing comorbidity from claims is common, but it may be advantageous to use all historical claims. We assessed how the strengt...

journal_title：Pharmacoepidemiology and drug safety

authors： Gilbertson DT,Bradbury BD,Wetmore JB,Weinhandl ED,Monda KL,Liu J,Brookhart MA,Gustafson SK,Roberts T,Collins AJ,Rothman KJ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Epidemiologic studies on a potential chemopreventive effect of statin therapy have yielded conflicting results. We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort. METHODS:A nested ca...

journal_title：Pharmacoepidemiology and drug safety

authors： Yang YX,Hennessy S,Propert K,Hwang WT,Sarkar M,Lewis JD

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To investigate suicide-related over-the-counter (OTC) analgesic medication exposures among individuals ≥6 years old reported to United States (US) poison control centers. METHODS:Data from the National Poison Data System for the years 2000-2018 were retrospectively analyzed. RESULTS:From 2000 to 2018, US pois...

journal_title：Pharmacoepidemiology and drug safety

authors： Hopkins AG,Spiller HA,Kistamgari S,Zhu M,Michaels NL,Funk AR,Smith GA

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To study adult height in children that grew up with asthma before inhaled steroids became first-line therapy. METHODS:Data from the Swedish Medical Birth Register (self-reported asthma) and the Hospital Discharge Register (first hospitalization for asthma) were used, to compare adult height for asthmatic and n...

journal_title：Pharmacoepidemiology and drug safety

authors： Norjavaara E,Gerhardsson de Verdier M,Lindmark B

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:The aims of this study are to examine the validity of diagnostic codes for psoriatic arthritis in The Health Improvement Network (THIN) and to examine the agreement between General Practitioner (GP) report and prescription records for disease modifying antirheumatic drugs (DMARDs). METHODS:Questionnaires were ...

journal_title：Pharmacoepidemiology and drug safety

authors： Ogdie A,Alehashemi S,Love TJ,Jiang Y,Haynes K,Hennessy S,Choi H,Gelfand JM

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The Epidemiologic Registry of Cystic Fibrosis (ERCF) was a multicentre, longitudinal follow-up project of cystic fibrosis patients enrolled at some 200 centres in nine European countries between 1994 and 1999. PURPOSE:We aimed to assess and improve the quality of a subset of data from the ERCF relating to s...

journal_title：Pharmacoepidemiology and drug safety

authors： Strobl J,Enzer I,Bagust A,Haycox A,Smyth R,Ashby D,Walley T

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children. METHODS:We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they receiv...

journal_title：Pharmacoepidemiology and drug safety

authors： Tran YH,Groen H,Bergman JE,Hak E,Wilffert B

更新日期：2017-03-01 00:00:00