Abstract:
:To provide a more precise genetic map of the p22.3-p21.2 region on the short arm of the human X chromosome, we performed multilocus linkage studies in an expanded database including 31 retinoschisis families and 40 normal families. Twelve loci from this region were examined. Although significant lod scores were observed between various pairs of markers by two-point linkage analysis, the confidence limits were found to be broad. The most likely gene order on the basis of multilocus analysis was Xpter-DXS89-DXS85-DXS16-(DXS207,DXS43++ +)-DXS274-(DXS41, DXS92)-ZFX-DXS164-Xcen. All other alternative orders were excluded by odds of at least 40:1.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Alitalo T,Kruse TA,Ahrens P,Albertsen HM,Eriksson AW,de la Chapelle Adoi
10.1007/BF00201548subject
Has Abstractpub_date
1991-04-01 00:00:00pages
599-603issue
6eissn
0340-6717issn
1432-1203journal_volume
86pub_type
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