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Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage.

Abstract：

OBJECTIVE:We investigated the potential involvement of the thromboxane A(2) (TXA(2)) pathway in human prostate cancer (PCa). METHODS:Expression of cyclooxygenase-2 (COX-2), TXA(2) synthase (TXS), and TXA(2) receptors (TPRs), the main actors of the TXA(2) pathway, was analyzed on serial tissue sections from 46 human PCa specimens. RESULTS:The expression levels of COX-2, TXS, and TPRs were significantly higher in malignant than in corresponding nontumoral prostatic epithelial cells. Increased immunoreactivity for these antigens was also observed in high-grade prostate intraepithelial neoplasia (HGPIN) glands. COX-2, TXS, and TPR proteins usually displayed a coordinated overexpression pattern in PCa lesions, as assessed in serial tissue sections. Increased levels of these proteins in the tumors were all significantly associated with higher Gleason scores and pathologic stages. CONCLUSIONS:Proteins specifically involved in the TXA(2) pathway are up-regulated in human PCa and their level of expression is associated with tumor extraprostatic extension and loss of differentiation. Our study is the first to examine simultaneously all key proteins involved in this pathway including TXA(2) receptors and results suggest that the TXA(2) pathway may be a potential target for PCa prevention/therapy.

journal_name

Eur Urol

journal_title

European urology

authors

Dassesse T,de Leval X,de Leval L,Pirotte B,Castronovo V,Waltregny D

doi

10.1016/j.eururo.2006.01.036

keywords:

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1021-31; discussion 1031

issue

5

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(06)00095-9

journal_volume

50

pub_type

杂志文章

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