Electrically induced muscle contractions influence bone density decline after spinal cord injury.

Abstract:

STUDY DESIGN:Longitudinal repeated-measures; within-subject control. OBJECTIVE:We examined the extent to which an isometric plantar flexion training protocol attenuates bone loss longitudinally after SCI. SUMMARY OF BACKGROUND DATA:After spinal cord injury (SCI), bone mineral density (BMD) of paralyzed extremities rapidly declines, likely because of loss of mechanical loading of bone via muscle contractions. METHODS:Six individuals with complete paralysis began a 3-year unilateral plantar flexor muscle activation program within 4.5 months after SCI. The opposite limb served as a control. Compliance with recommended dose was > 80%. Tibia compressive force was > 140% of body weight. RESULTS:Bilateral hip and untrained tibia BMD declined significantly over the course of the training. Lumbar spine BMD showed minimal change. Percent decline in BMD (from the baseline condition) for the trained tibia (approximately 10%) was significantly less than the untrained tibia (approximately 25%) (P < 0.05). Trained limb percent decline in BMD remained steady over the first 1.5 years of the study (P < 0.05). CONCLUSIONS:Compressive loads of approximately 1 to 2 times body weight, induced by muscle contractions, partially prevent the loss of BMD after SCI. Future studies should establish dose-response curves for attenuation of bone loss after SCI.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Shields RK,Dudley-Javoroski S,Law LA

doi

10.1097/01.brs.0000201303.49308.a8

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

548-53

issue

5

eissn

0362-2436

issn

1528-1159

pii

00007632-200603010-00010

journal_volume

31

pub_type

杂志文章

相关文献

SPINE文献大全
  • Migration of a Lumbar Spinal Fusion Rod Into the Posterolateral Knee: A Case Report.

    abstract:STUDY DESIGN:Case report (level V evidence). OBJECTIVE:We report a case of a 33-year-old man with Marfan syndrome that visited our clinic for left knee pain and stiffness. Radiographs of the left knee and lumbar spine demonstrated a spinal rod in the posterolateral left knee and its origin being a broken rod from his ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003804

    authors: Long MK,Enders T,Leven D,Cappellino A

    更新日期:2021-02-01 00:00:00

  • Predictors of bad and good outcomes of lumbar disc surgery. A prospective clinical study with recommendations for screening to avoid bad outcomes.

    abstract:STUDY DESIGN:Patients were assessed by independent research teams in six different spine centers after indication for discectomy was established. Six- and twelve-month follow-ups were performed. OBJECTIVES:Objectives of this study were to determine somatic subjective symptoms, objective signs, sociodemographic, and ps...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199502001-00009

    authors: Junge A,Dvorak J,Ahrens S

    更新日期:1995-02-15 00:00:00

  • Postoperative Perfection: Ceiling Effects and Lack of Discrimination With Both SRS-22 and -24 Outcomes Instruments in Patients With Adolescent Idiopathic Scoliosis.

    abstract:STUDY DESIGN:Review of a prospective database registry. OBJECTIVE:To compare the Scoliosis Research Society (SRS)-22 and SRS-24 outcomes instruments in terms of scores, rate of ceiling effects, and discriminant ability in patients with pre- and postoperative adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0000000000001082

    authors: Bastrom TP,Bartley C,Marks MC,Yaszay B,Newton PO,Harms Study Group.

    更新日期:2015-12-01 00:00:00

  • The role of anterior spinal instrumentation and allograft fibula for the treatment of pott disease.

    abstract:STUDY DESIGN:The authors retrospectively reviewed 28 patients with multilevel Pott disease who underwent anterior radical débridement, decompression, and fusion with anterior spinal instrumentation and fibular allograft replacement. OBJECTIVES:To assess the efficacy of allograft fibular fusion and anterior spinal stab...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000048666.17934.17

    authors: Ozdemir HM,Us AK,Oğün T

    更新日期:2003-03-01 00:00:00

  • Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc Degeneration.

    abstract:STUDY DESIGN:Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE:This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potential mechanism in human nucleus pulposus cells. SUMMARY OF BACKGROUND ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001954

    authors: Guo J,Shao M,Lu F,Jiang J,Xia X

    更新日期:2017-07-01 00:00:00

  • Osteoid osteomas and osteoblastomas of the occipitocervical junction.

    abstract:STUDY DESIGN:We describe our surgical experience to remove osteoid osteomas and osteoblastomas of the occipitocervical junction. In this location, vertebral artery vicinity requires special consideration. OBJECTIVES:We illustrate our surgical approaches to remove lesions confidently, while minimizing bone resection to...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000180489.50171.ee

    authors: Bruneau M,Cornelius JF,George B

    更新日期:2005-10-01 00:00:00

  • The Impact of Preoperative Angiographic Identification of the Artery of Adamkiewicz on Surgical Decision Making in Patients Undergoing Thoracolumbar Corpectomy.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To investigate the impact of spinal angiography on selection of surgical side in patients undergoing thoracolumbar corpectomy. SUMMARY OF BACKGROUND DATA:The artery of Adamkiewicz provides the major blood supply to the thoracolumbar spinal cord. Its location makes it vulner...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000909

    authors: Fanous AA,Lipinski LJ,Krishna C,Roger EP,Siddiqui AH,Levy EI,Leonardo J,Pollina J

    更新日期:2015-08-01 00:00:00

  • Postoperative Resolution of MR T2 Increased Signal Intensity in Cervical Spondylotic Myelopathy: The Impact of Signal Change Resolution on the Outcomes.

    abstract:STUDY DESIGN:A prospective comparative imaging study. OBJECTIVE:This study investigated whether postoperative resolution of spinal cord increased signal intensity (ISI) reflected symptom improvement and surgical outcomes in cervical spondylotic myelopathy (CSM) patients. SUMMARY OF BACKGROUND DATA:Although some CSM p...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003128

    authors: Machino M,Ando K,Kobayashi K,Ota K,Morozumi M,Tanaka S,Ito K,Kato F,Ishiguro N,Imagama S

    更新日期:2019-11-01 00:00:00

  • Is There a Relationship Between Bony Fusion After Anterior Cervical Discectomy and Fusion and Heterotopic Ossification After Cervical Disc Arthroplasty in Hybrid Surgery?

    abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:The aim of this study was to investigate the relationship between bony fusion after anterior cervical discectomy and fusion (ACDF) and heterotopic ossification (HO) after cervical disc arthroplasty (CDA) in hybrid surgery (HS). SUMMARY OF BACKGROUND DATA:The mechanism of...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003687

    authors: He J,Ding C,Liu H,Wu T,Huang K,Wang B,Hong Y,Liu Y

    更新日期:2020-12-15 00:00:00

  • Risk of vertebrobasilar stroke and chiropractic care: results of a population-based case-control and case-crossover study.

    abstract:STUDY DESIGN:Population-based, case-control and case-crossover study. OBJECTIVE:To investigate associations between chiropractic visits and vertebrobasilar artery (VBA) stroke and to contrast this with primary care physician (PCP) visits and VBA stroke. SUMMARY OF BACKGROUND DATA:Chiropractic care is popular for neck...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181644600

    authors: Cassidy JD,Boyle E,Côté P,He Y,Hogg-Johnson S,Silver FL,Bondy SJ

    更新日期:2008-02-15 00:00:00

  • Quantitative dynamic measures of physical exposure predict low back functional impairment.

    abstract:STUDY DESIGN:Prospective field study of work exposure and changes in back function. OBJECTIVE:Quantify dynamic physical exposures in the workplace and their association with decreases in kinematic back function (indicative of low back pain [LBP]). SUMMARY OF BACKGROUND DATA:Previous epidemiologic studies of work have...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181ce1201

    authors: Marras WS,Lavender SA,Ferguson SA,Splittstoesser RE,Yang G

    更新日期:2010-04-15 00:00:00

  • Peroperative three-dimensional correction of idiopathic scoliosis with the Cotrel-Dubousset procedure.

    abstract:STUDY DESIGN:A peroperative measurement technique based on magnetic fields was used to document the thoracic and lumbar vertebral changes induced by derotation of the concave rod during corrective surgery of idiopathic scoliotic deformities with Cotrel-Dubousset instrumentation. OBJECTIVES:Objective was to accurately ...

    journal_title:Spine

    pub_type: 临床试验,杂志文章

    doi:

    authors: Labelle H,Dansereau J,Bellefleur C,de Guise J,Rivard CH,Poitras B

    更新日期:1995-06-15 00:00:00

  • Influence of the Preoperative Neurological Status on Survival After the Surgical Treatment of Symptomatic Spinal Metastases With Spinal Cord Compression.

    abstract:STUDY DESIGN:Consecutive case-series. OBJECTIVE:The main purpose of this study was to analyze the relationship between the preoperative neurological status and subsequent survival of patients undergoing surgical treatment for symptomatic spinal metastases. SUMMARY OF BACKGROUND DATA:The survival of cancer patients ha...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001141

    authors: Vanek P,Bradac O,Trebicky F,Saur K,de Lacy P,Benes V

    更新日期:2015-12-01 00:00:00

  • Direct application of the TNF-alpha inhibitor, etanercept, does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats.

    abstract:STUDY DESIGN:Immunohistological and behavioral analysis of the effect of a tumor necrosis factor alpha (TNF-alpha) inhibitor in an injured-nerve model. OBJECTIVE:To examine the effect of direct application of a TNF-alpha inhibitor (etanercept) on injured-nerve pain caused by nucleus pulposus. SUMMARY AND BACKGROUND D...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31818441a2

    authors: Norimoto M,Ohtori S,Yamashita M,Inoue G,Yamauchi K,Koshi T,Suzuki M,Orita S,Eguchi Y,Sugiura A,Ochiai N,Takaso M,Takahashi K

    更新日期:2008-10-15 00:00:00

  • Forces in the halo-vest apparatus.

    abstract::A previous study by Koch and Nickel (1978) determined the changes in the distraction forces in the halo-vest during different activities. The present study determined the variations of forces in different directions between the halo and the vest also during different activities. Clip-on strain gauges were used to meas...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198411000-00001

    authors: Walker PS,Lamser D,Hussey RW,Rossier AB,Farberov A,Dietz J

    更新日期:1984-11-01 00:00:00

  • Cost Variation Within Spinal Fusion Payment Groups.

    abstract:STUDY DESIGN:Retrospective, large administrative database. OBJECTIVE:To investigate cost variation within current spinal fusion diagnosis-related groups (DRGs). SUMMARY OF BACKGROUND DATA:Medicare reimbursement to hospitals for spinal fusion surgery is provided as a fixed payment for each admission based on DRG. This...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001649

    authors: Wright DJ,Mukamel DB,Greenfield S,Bederman SS

    更新日期:2016-11-15 00:00:00

  • Back surface curvature and measurement of lumbar spinal motion.

    abstract::Lumbar spinal flexion and extension motion was measured radiographically and from the back surface curvature in 42 patients with low-back pain to determine whether the surface measurements provided accurate measurement of the total lumbar spinal motion and its distribution by vertebral level. Also, a biomechanical mod...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198705000-00009

    authors: Stokes IA,Bevins TM,Lunn RA

    更新日期:1987-05-01 00:00:00

  • Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation.

    abstract:STUDY DESIGN:Examination of ADAMTS-4 expression, and cellular lineages, distribution, and numbers of ADAMTS-4 (aggrecanase-1) expressing cells in herniated lumbar intervertebral discs. OBJECTIVE:To determine the expression of ADAMTS-4, a metalloproteinase capable of digesting aggrecan, and its role in herniated lumbar...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000219954.67368.be

    authors: Hatano E,Fujita T,Ueda Y,Okuda T,Katsuda S,Okada Y,Matsumoto T

    更新日期:2006-06-01 00:00:00

  • The effects of an interspinous implant on the kinematics of the instrumented and adjacent levels in the lumbar spine.

    abstract:STUDY DESIGN:Measurement of the kinematics of the lumbar spine after insertion of an interspinous spacer in vitro. OBJECTIVES:To understand the kinematics of the instrumented and adjacent levels due to the insertion of this interspinous implant. SUMMARY OF BACKGROUND DATA:An interspinous spacer (X Stop, SFMT, Concord...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000084877.88192.8E

    authors: Lindsey DP,Swanson KE,Fuchs P,Hsu KY,Zucherman JF,Yerby SA

    更新日期:2003-10-01 00:00:00

  • Treatment of irreducible old atlantoaxial subluxation with cable-dragged reduction and cantilever beam internal fixation.

    abstract:STUDY DESIGN:Retrospective case series study of surgical outcome for 21 atlantoaxial subluxation patients treated with a new technique, called cable-dragged reduction/cantilever beam internal fixation. Surgery was performed by a single surgeon. OBJECTIVE:To describe and evaluate the cable-dragged reduction/cantilever ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181feb6b1

    authors: Liu X,Liu H,Li T,Gong Q,Song Y,Liu L,Shi R,Zhao X,Zhang W,Feng G,Wang B

    更新日期:2011-07-01 00:00:00

  • Outcomes of disabling cervical spine disorders in compensation injuries. A prospective comparison to tertiary rehabilitation response for chronic lumbar spinal disorders.

    abstract:STUDY DESIGN:A prospective, longitudinal cohort study assessing quantitative socioeconomic outcomes of tertiary rehabilitation for chronically disabled patients with cervical spinal disorders compared with those with more common chronic lumbar spinal disorders. OBJECTIVES:To assess 1-year socioeconomic outcomes of a w...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199901150-00020

    authors: Wright A,Mayer TG,Gatchel RJ

    更新日期:1999-01-15 00:00:00

  • Direct vertebral body derotation, thoracoplasty, or both: which is better with respect to inclinometer and scoliosis research society-22 scores?

    abstract:STUDY DESIGN:Prospective, longitudinal cohort (nonrandomized). OBJECTIVE:To compare thoracoplasty (Th), direct vertebral body derotation (DVBD), and Th and DVBD with respect to correction of the rib prominence and Scoliosis Research Society (SRS) self-image scores in patients undergoing surgery for adolescent idiopath...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31824a4911

    authors: Samdani AF,Hwang SW,Miyanji F,Lonner B,Marks MC,Sponseller PD,Newton PO,Cahill PJ,Shufflebarger HL,Betz RR

    更新日期:2012-06-15 00:00:00

  • What occupant kinematics and neuromuscular responses tell us about whiplash injury.

    abstract:STUDY DESIGN:Literature-based review. OBJECTIVE:To review the published data on occupant kinematic and neuromuscular responses during low-speed impacts and analyze how these data inform our understanding of whiplash injury. SUMMARY OF BACKGROUND DATA:A stereotypical kinematic and neuromuscular response has been obser...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3182387d71

    authors: Siegmund GP

    更新日期:2011-12-01 00:00:00

  • Postoperative Disability After Long Corrective Fusion to the Pelvis in Elderly Patients With Spinal Deformity.

    abstract:STUDY DESIGN:A prospective case series analysis. OBJECTIVE:The purpose of this study was to investigate the degree of difficulty in daily activities of adult spinal deformity (ASD) patients after corrective long fusion to the pelvis, with an emphasis on bend forward activities. SUMMARY OF BACKGROUND DATA:No prospecti...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002540

    authors: Togawa D,Hasegawa T,Yamato Y,Yoshida G,Kobayashi S,Yasuda T,Oe S,Banno T,Arima H,Mihara Y,Ushirozako H,Matsuyama Y

    更新日期:2018-07-15 00:00:00

  • Metastatic pulmonary intimal sarcoma presenting as cauda equina syndrome: first report of a case.

    abstract:STUDY DESIGN:Case report and clinical discussion. OBJECTIVE:To describe a rare case of metastatic pulmonary intimal sarcoma presenting as cauda equine syndrome. SUMMARY OF BACKGROUND DATA:Pulmonary artery sarcoma is a rare tumor, frequently misdiagnosed as pulmonary embolism, and although it is highly aggressive, met...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31817cf7ef

    authors: Rashid A,Molloy S,Lehovsky J,Tirabosco R,Hughes R,Butt S

    更新日期:2008-07-01 00:00:00

  • Functional rating index: a new valid and reliable instrument to measure the magnitude of clinical change in spinal conditions.

    abstract:STUDY DESIGN:A prospective cohort design was used to evaluate the Functional Rating Index in a multicentered setting with 139 participants. The Functional Rating Index is a self-reporting instrument consisting of 10 items, each with 5 possible responses that express graduating degrees of disability. OBJECTIVES:The goa...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00007632-200101010-00015

    authors: Feise RJ,Michael Menke J

    更新日期:2001-01-01 00:00:00

  • Inpatient Pain Scores and Narcotic Utilization Based on American Society of Anesthesiologists Score Following Anterior Cervical Discectomy and Fusion.

    abstract:STUDY DESIGN:Retrospective. OBJECTIVE:To examine the relationship between American Society of Anesthesiologists (ASA) score and inpatient pain and narcotics consumption following anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA:Higher ASA scores have been previously linked to increased posto...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003135

    authors: Yoo JS,Brundage TS,Hrynewycz NM,Singh K

    更新日期:2019-11-15 00:00:00

  • Can infant malnutrition cause adult vertebral stenosis?

    abstract::Does infant malnutrition produce smaller adult spinal canals? Lumbar and thoracic vertebrae (n X 1073), from a prehistoric American Indian population (15-55 yrs of age), were measured for anteroposterior (AP) and transverse (TR) vertebral canal sizes, nerve root tunnel (intervertebral foramen) widths (NRT), vertebral ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198503000-00012

    authors: Clark GA,Panjabi MM,Wetzel FT

    更新日期:1985-03-01 00:00:00

  • Is It Necessary to Extend a Multilevel Posterior Cervical Decompression and Fusion to the Upper Thoracic Spine?

    abstract:STUDY DESIGN:A retrospective cohort analysis. OBJECTIVE:The aim of this study was to determine if there is a difference in the revision rate in patients who undergo a multilevel posterior cervical fusions ending at C7, T1, or T2-T4. SUMMARY OF BACKGROUND DATA:Multilevel posterior cervical decompression and fusion is ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001864

    authors: Schroeder GD,Kepler CK,Kurd MF,Mead L,Millhouse PW,Kumar P,Nicholson K,Stawicki C,Helber A,Fasciano D,Patel AA,Woods BI,Radcliff KE,Rihn JA,Anderson DG,Hilibrand AS,Vaccaro AR

    更新日期:2016-12-01 00:00:00

  • Health-related quality of life and low back pain of patients surgically treated for scoliosis after 21 years or more of follow-up: comparison among nonidiopathic scoliosis, idiopathic scoliosis, and healthy subjects.

    abstract:STUDY DESIGN:A case-control study. OBJECTIVE:To compare health-related quality of life and low back pain of healthy subjects with those of patients with nonidiopathic scoliosis (non-IS) and idiopathic scoliosis (IS) 21 years or more after surgery. SUMMARY OF BACKGROUND DATA:There have been a very small number of repo...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31825a22c2

    authors: Akazawa T,Minami S,Kotani T,Nemoto T,Koshi T,Takahashi K

    更新日期:2012-10-15 00:00:00