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Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids.

Abstract：

:The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a series of gamma-keto carboxylic acids are described. Among nine MMP isozymes tested, compound 1j displays selective inhibition of MMP-2, -9, and -12 with IC(50) values between 0.20 and 1.51 microuM, and in male golden Syrian hamsters, it shows protection against PPE-induced emphysema.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Ma D,Jiang Y,Chen F,Gong LK,Ding K,Xu Y,Wang R,Ge A,Ren J,Li J,Li J,Ye Q

doi

10.1021/jm051101g

keywords:

subject

Has Abstract

pub_date

2006-01-26 00:00:00

pages

456-8

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

49

pub_type

杂志文章

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