Abstract:
OBJECTIVE:To examine the basal thyroid function in pediatric Obsessive Compulsive Disorder (OCD) versus controls, and to explore the relation between baseline thyroid measures and response to clomipramine treatment, and the effects of treatment on thyroid hormones. METHODS:Sixteen children and adolescents with DSM-III-R OCE and 13 control children and adolescents without psychiatric illness were compared on basal measures of thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). For the OCD subjects, samples were compared pre- and post- 4 weeks of treatment with clomipramine. Response of OCD symptoms was measured by the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS). RESULTS:OCD subjects demonstrated subtle but significant elevations of TSH, T3, and T4 pre-treatment compared to controls. Clomipramine treatment was associated with significant decreases in TSH and T3 concentrations. Pre-treatment TSH and T4 concentrations correlated with reductions in CY-BOCS following 8 weeks of clomipramine. CONCLUSION:Elevated thyroid function at baseline may be a biomarker of OCD improvement, and may reflect aspects of the underlying pathophysiology of OCD.
journal_name
J Child Adolesc Psychopharmacoljournal_title
Journal of child and adolescent psychopharmacologyauthors
McCracken JT,Hanna GLdoi
10.1089/cap.2005.15.581keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
581-7issue
4eissn
1044-5463issn
1557-8992journal_volume
15pub_type
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journal_title:Journal of child and adolescent psychopharmacology
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Journal of child and adolescent psychopharmacology
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更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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更新日期:2008-12-01 00:00:00
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更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
doi:10.1089/cap.2005.15.693
更新日期:2005-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
doi:10.1089/cap.1996.6.273
更新日期:1996-01-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-05-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
doi:10.1089/cap.2007.0026
更新日期:2008-04-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00