当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations.

Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations.

Abstract：

:A fragment-based docking procedure followed by substructure search were used to identify active-site beta-secretase inhibitors from a composite set of about 300 000 and a library of nearly 180 000 small molecules, respectively. EC(50) values less than 10 microM were measured in at least one of two different mammalian cell-based assays for 12 of the 72 purchased compounds. In particular, the phenylureathiadiazole 2 and the diphenylurea derivative 3 are promising lead compounds for beta-secretase inhibition.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Huang D,Lüthi U,Kolb P,Edler K,Cecchini M,Audetat S,Barberis A,Caflisch A

doi

10.1021/jm050499d

keywords:

subject

Has Abstract

pub_date

2005-08-11 00:00:00

pages

5108-11

issue

16

eissn

0022-2623

issn

1520-4804

journal_volume

48

pub_type

杂志文章

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