Abstract：
:We describe a mathematical model linking changes in cerebral blood flow, blood volume and the blood oxygenation state in response to stimulation. The model has three compartments to take into account the fact that the cerebral blood flow and volume as measured concurrently using laser Doppler flowmetry and optical imaging spectroscopy have contributions from the arterial, capillary as well as the venous compartments of the vasculature. It is an extension to previous one-compartment hemodynamic models which assume that the measured blood volume changes are from the venous compartment only. An important assumption of the model is that the tissue oxygen concentration is a time varying state variable of the system and is driven by the changes in metabolic demand resulting from changes in neural activity. The model takes into account the pre-capillary oxygen diffusion by flexibly allowing the saturation of the arterial compartment to be less than unity. Simulations are used to explore the sensitivity of the model and to optimise the parameters for experimental data. We conclude that the three-compartment model was better than the one-compartment model at capturing the hemodynamics of the response to changes in neural activation following stimulation.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Zheng Y,Johnston D,Berwick J,Chen D,Billings S,Mayhew Jdoi
10.1016/j.neuroimage.2005.06.042keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
925-39issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(05)00485-4journal_volume
28pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:MRI at 3 T has increased sensitivity in detecting overt multiple sclerosis (MS) brain lesions; a growing body of data suggests clinically relevant damage occurs in the normal-appearing white matter (NAWM). We tested a novel pulse sequence to determine whether 3 T MRI spin-spin relaxometry detected damage in NAWM of MS...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.03.001
更新日期：2009-07-01 00:00:00
abstract：:Functional activation patterns of an auditory working memory task were examined prior to and after 5 days of training (1 h/day). A control group with no training was scanned twice at the same intervals to assess test-retest effects. Based on behavioral improvement scores, the training group (n = 14) was divided into "...
journal_title：NeuroImage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroimage.2005.11.046
更新日期：2006-05-15 00:00:00
abstract：:The ability to regulate emotions is essential for adaptive behavior. This ability is suggested to be mediated by the connectivity between prefrontal brain regions and the amygdala. Yet, it is still unknown whether the ability to regulate emotions can be trained by using a non-emotional procedure, such as the recruitme...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.10.069
更新日期：2016-01-15 00:00:00
abstract：:Functional neuroimaging research in humans has identified a number of brain areas that are activated by the delivery of primary and secondary reinforcers. The present study investigated how activity in these reward-sensitive regions is modulated by the context in which rewards and punishments are experienced. Fourteen...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2004.12.043
更新日期：2005-05-01 00:00:00
abstract：:In this study, we have assessed the validity and reliability of an automated labeling system that we have developed for subdividing the human cerebral cortex on magnetic resonance images into gyral based regions of interest (ROIs). Using a dataset of 40 MRI scans we manually identified 34 cortical ROIs in each of the ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.01.021
更新日期：2006-07-01 00:00:00
abstract：:Positron emission tomography (PET) was used to determine the effect of working memory and speed of sentence processing on regional cerebral blood flow (rCBF) during syntactic processing in sentence comprehension. PET activity associated with making plausibility judgments about syntactically more complex subject-object...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/s1053-8119(03)00007-7
更新日期：2003-05-01 00:00:00
abstract：:Human posterior cingulate cortex (PCC) and retrosplenial cortex (RSC) form the posterior cingulate gyrus, however, monkey connection and human imaging studies suggest that PCC area 23 is not uniform and atlases mislocate RSC. We histologically assessed these regions in 6 postmortem cases, plotted a flat map, and chara...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.07.048
更新日期：2006-01-15 00:00:00
abstract：:Our goal is to study the human brain anatomical network. For this, the anatomical connection probabilities (ACP) between 90 cortical and subcortical brain gray matter areas are estimated from diffusion-weighted Magnetic Resonance Imaging (DW-MRI) techniques. The ACP between any two areas gives the probability that tho...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.10.060
更新日期：2008-04-15 00:00:00
abstract：:High resolution electroencephalography (HR-EEG) combined with source localization methods has mainly been used to study interictal spikes and there have been few studies comparing source localization of scalp ictal patterns with depth EEG. To address this issue, 10 patients with four different scalp ictal patterns (ic...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.02.067
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:The dopamine D2/3 receptor subtypes (DRD2/3) are the most widely studied neurotransmitter biomarker in research on obesity, but results to date have been inconsistent, have typically involved small samples, and have rarely accounted for subjects' ages despite the large impact of age on DRD2/3 levels. We aimed...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.05.044
更新日期：2016-09-01 00:00:00
abstract：:In this study, we examined the impact of goal-directed processing on the response to emotional pictures and the impact of emotional pictures on goal-directed processing. Subjects (N=22) viewed neutral or emotional pictures in the presence or absence of a demanding cognitive task. Goal-directed processing disrupted the...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.11.048
更新日期：2007-03-01 00:00:00
abstract：:Cognitive action control depends on cortical-subcortical circuits, involving notably the subthalamic nucleus (STN), as evidenced by local field potentials recordings (LFPs) studies. The STN consistently shows an increase in theta oscillations power during conflict resolution. Some studies have shown that cognitive act...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.04.071
更新日期：2019-08-15 00:00:00
abstract：:This study examined neural responses in nine right-handed healthy individuals while they viewed mild and intense expressions of four emotions (fear, disgust, happiness, and sadness) contrasted with neutral faces in four event-related functional magnetic resonance imaging experiments. Orthogonal polynomial trend analys...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/s1053-8119(03)00085-5
更新日期：2003-08-01 00:00:00
abstract：:The key idea of statistical hypothesis testing is to fix, and thereby control, the Type I error (false positive) rate across samples of any size. Multiple comparisons inflate the global (family-wise) Type I error rate and the traditional solution to maintaining control of the error rate is to increase the local (compa...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.08.009
更新日期：2015-12-01 00:00:00
abstract：:Motor tasks involve neural activity in a spatially distributed network. It is assumed that coherent activity between these brain structures reflects functional connectivity. The aim of the present study was to investigate brain areas associated with a unimanual auditorily paced finger-tapping task and to characterize ...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2004.10.009
更新日期：2005-02-01 00:00:00
abstract：:The length of a vocal tract is reflected in the sound it is producing. The length of the vocal tract is correlated with body size and humans are very good at making size judgments based on the acoustic effect of vocal tract length only. Here we investigate the underlying mechanism for processing this main auditory cue...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.02.045
更新日期：2006-08-01 00:00:00
abstract：:Memory consolidation is a long-lasting dynamic process by which new acquired information is transformed at different analysis levels, from molecules to cognition, without additional practice. Results from a previous study on event-related potentials (ERPs) suggest that part of the neural events promoting changes in th...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.02.014
更新日期：2005-06-01 00:00:00
abstract：:Semantic processing entails the activation of widely distributed brain areas across the temporal, parietal, and frontal lobes. To understand the functional structure of this semantic system, we examined its intrinsic functional connectivity pattern using a database of 146 participants. Focusing on areas consistently a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.03.004
更新日期：2016-05-15 00:00:00
abstract：:Neuroimaging has been facing a data deluge characterized by the exponential growth of both raw and processed data. As a result, mining the massive quantities of digital data collected in these studies offers unprecedented opportunities and has become paramount for today's research. As the neuroimaging community enters...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.08.076
更新日期：2016-01-01 00:00:00
abstract：:Certain groups (e.g., women, older adults, and the economically disadvantaged) are universally stigmatized. Numerous studies, however, have identified cross-cultural differences in the attitudes expressed toward stigmatized groups. These differences may potentially be due to existing cross-cultural dissimilarities in ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.08.030
更新日期：2016-01-01 00:00:00
abstract：:This study investigates how visual cortical networks align with context-sensitivity, namely the relative focus on the object versus the background of a visual scene, in early childhood. Context-sensitivity was assessed by a picture description and a recognition memory task. To segregate object and background processin...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.08.008
更新日期：2017-12-01 00:00:00
abstract：:Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly characterized from brain diffusion MRI. In addition, to enable analysis of WM tracts ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.116993
更新日期：2020-09-01 00:00:00
abstract：:The impulse to act for immediate reward often conflicts with more deliberate evaluations that support long-term benefit. The neural architecture that negotiates this conflict remains unclear. One account proposes a single neural circuit that evaluates both immediate and delayed outcomes, while another outlines separat...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.12.071
更新日期：2015-04-01 00:00:00
abstract：:Although depressive mood is an important psychological determinate of chronic pain, the neural circuitry that mediates its influence on the pain experience is largely unknown. We used functional magnetic resonance imaging (FMRI) to investigate the neurophysiological interactions between depressive symptoms and disease...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.12.016
更新日期：2008-04-01 00:00:00
abstract：:The purpose of this study was to investigate whether current or lifetime alcohol intake is related to focal gray and white matter in healthy non-alcohol-dependent drinkers, and, if so, whether these densities are related to functional brain activity associated with visual attention. Voxel-based morphometric analyses o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.01.036
更新日期：2005-06-01 00:00:00
abstract：:Whereas we know a fair amount on the role of the amygdala in the acute stress response, virtually nothing is known about its role during the recovery period after the stress has waned. Functional connectivity analysis of the amygdala during this period might be useful in revealing brain circuits promoting adaptive rec...
journal_title：NeuroImage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroimage.2011.05.074
更新日期：2011-08-15 00:00:00
abstract：BACKGROUND:The primary purpose of this investigation was to assess the neural correlates of implicit cueing during an inhibitory task in schizophrenia when performance accuracy was matched with healthy comparison subjects. METHODS:We compared 17 individuals with chronic schizophrenia (SZ; medicated, 13.9 average years...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.04.189
更新日期：2006-08-15 00:00:00
abstract：OBJECTIVE:Virtual endoscopic simulations using volume rendering (VR) have been proposed as a tool for training and understanding intraventricular anatomy. It is not known whether surface rendering (SR), an alternative to VR, can visualize intraventricular and subependymal structures better and thus making the virtual e...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.04.023
更新日期：2007-01-01 00:00:00
abstract：:Developmental research, as well as paediatric clinical activity crucially depends on non-invasive and painless brain recording techniques, such as electroencephalography (EEG), and near infrared spectroscopy (NIRS). However, both of these techniques measure cortical activity from the scalp without precise knowledge of...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.05.046
更新日期：2014-10-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) in sighted individuals previously showed parahippocampal and fusiform activations during locomotor imagery, which were interpreted to reflect visuospatial navigation. Concurrent deactivations of multisensory vestibular and somatosensory cortical areas may reflect suppressio...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.11.029
更新日期：2009-03-01 00:00:00
