Using executive control training to suppress amygdala reactivity to aversive information.


:The ability to regulate emotions is essential for adaptive behavior. This ability is suggested to be mediated by the connectivity between prefrontal brain regions and the amygdala. Yet, it is still unknown whether the ability to regulate emotions can be trained by using a non-emotional procedure, such as the recruitment of executive control (EC). Participants who were trained using a high-frequent executive control (EC) task (80% incongruent trials) showed reduced amygdala reactivity and behavioral interference of aversive pictures. These effects were observed only following multiple-session training and not following one training session. In addition, they were not observed for participants exposed to low-frequent EC training (20% incongruent trials). Resting-state functional connectivity analysis revealed a marginally significant interaction between training group and change in the connectivity between the amygdala and the right inferior frontal gyrus (IFG). Amygdala-IFG connectivity was significantly increased following the training only in the high-frequent EC training group. These findings are the first to show that non-emotional training can induce changes in amygdala reactivity to aversive information and alter amygdala-prefrontal connectivity.






Cohen N,Margulies DS,Ashkenazi S,Schaefer A,Taubert M,Henik A,Villringer A,Okon-Singer H




Has Abstract


2016-01-15 00:00:00












  • Tracking cortical activity from M/EEG using graph cuts with spatiotemporal constraints.

    abstract::This work proposes to use magnetoencephalography (MEG) and electroencephalography (EEG) source imaging to provide cinematic representations of the temporal dynamics of cortical activations. Cortical activation maps, seen as images of the active brain, are scalar maps defined at the vertices of a triangulated cortical ...


    pub_type: 杂志文章


    authors: Gramfort A,Papadopoulo T,Baillet S,Clerc M

    更新日期:2011-02-01 00:00:00

  • Multifocal tDCS targeting the resting state motor network increases cortical excitability beyond traditional tDCS targeting unilateral motor cortex.

    abstract::Scientists and clinicians have traditionally targeted single brain regions with stimulation to modulate brain function and disease. However, brain regions do not operate in isolation, but interact with other regions through networks. As such, stimulation of one region may impact and be impacted by other regions in its...


    pub_type: 杂志文章


    authors: Fischer DB,Fried PJ,Ruffini G,Ripolles O,Salvador R,Banus J,Ketchabaw WT,Santarnecchi E,Pascual-Leone A,Fox MD

    更新日期:2017-08-15 00:00:00

  • Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression.

    abstract::Human depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate corte...


    pub_type: 杂志文章


    authors: Grandjean J,Azzinnari D,Seuwen A,Sigrist H,Seifritz E,Pryce CR,Rudin M

    更新日期:2016-11-15 00:00:00

  • Large-scale brain functional modularity is reflected in slow electroencephalographic rhythms across the human non-rapid eye movement sleep cycle.

    abstract::Large-scale brain functional networks (measured with functional magnetic resonance imaging, fMRI) are organized into separated but interacting modules, an architecture supporting the integration of distinct dynamical processes. In this work we study how the aforementioned modular architecture changes with the progress...


    pub_type: 杂志文章


    authors: Tagliazucchi E,von Wegner F,Morzelewski A,Brodbeck V,Borisov S,Jahnke K,Laufs H

    更新日期:2013-04-15 00:00:00

  • Local and remote functional connectivity of neocortex under the inhibition influence.

    abstract::The current paper focuses on a relatively new and promising area of the study of EEG transformations during brain information processing based on the reduction of the signal to the discrete quasi-stationary segment sequences which may reflect individual brain microstates or discrete operations. In this framework, the ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fingelkurts AA,Fingelkurts AA,Kivisaari R,Pekkonen E,Ilmoniemi RJ,Kähkönen S

    更新日期:2004-07-01 00:00:00

  • The neural networks underlying endogenous auditory covert orienting and reorienting.

    abstract::Auditory information communicated through vocalizations, music, or sounds in the environment is commonly used to orient and direct attention to different locations in extrapersonal space. The neural networks subserving attention to auditory space remain poorly understood in comparison to our knowledge about attention ...


    pub_type: 杂志文章


    authors: Mayer AR,Harrington D,Adair JC,Lee R

    更新日期:2006-04-15 00:00:00

  • Molecular X-ray computed tomography of myelin in a rat brain.

    abstract::In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodici...


    pub_type: 杂志文章


    authors: Jensen TH,Bech M,Bunk O,Menzel A,Bouchet A,Le Duc G,Feidenhans'l R,Pfeiffer F

    更新日期:2011-07-01 00:00:00

  • The fine line between 'brave' and 'reckless': amygdala reactivity and regulation predict recognition of risk.

    abstract:BACKGROUND:High sensation-seekers (HSS) pursue novelty even at the cost of self-harm. When challenged, HSS are less anxious, show blunted physiological (cortisol, startle) and neurobiological (prefrontal-limbic) responses, and devalue aversive outcomes. Here, we investigate how these features interact under conditions ...


    pub_type: 杂志文章


    authors: Mujica-Parodi LR,Carlson JM,Cha 차지욱 J,Rubin D

    更新日期:2014-12-01 00:00:00

  • Cross-modal and non-monotonic representations of statistical regularity are encoded in local neural response patterns.

    abstract::Current neurobiological models assign a central role to predictive processes calibrated to environmental statistics. Neuroimaging studies examining the encoding of stimulus uncertainty have relied almost exclusively on manipulations in which stimuli were presented in a single sensory modality, and further assumed that...


    pub_type: 杂志文章


    authors: Nastase SA,Davis B,Hasson U

    更新日期:2018-06-01 00:00:00

  • Effects of magnetization transfer on T1 contrast in human brain white matter.

    abstract::MRI based on T1 relaxation contrast is increasingly being used to study brain morphology and myelination. Although it provides for excellent distinction between the major tissue types of gray matter, white matter, and CSF, reproducible quantification of T1 relaxation rates is difficult due to the complexity of the con...


    pub_type: 杂志文章


    authors: van Gelderen P,Jiang X,Duyn JH

    更新日期:2016-03-01 00:00:00

  • Watch out! Medial frontal cortex is activated by cues signaling potential changes in response demands.

    abstract::The human medial frontal cortex and especially the anterior cingulate cortex (ACC) have been implicated in several aspects of performance monitoring. We examined event-related EEG during a general process of controlling attention by using a novel paradigm to elicit a medial frontal negativity (MFN) to stimuli that ind...


    pub_type: 杂志文章


    authors: van Noordt SJ,Desjardins JA,Segalowitz SJ

    更新日期:2015-07-01 00:00:00

  • Event-related brain potentials reveal the time-course of language change detection in early bilinguals.

    abstract::Using event-related brain potentials, we investigated the temporal course of language change detection in proficient bilinguals as compared to matched controls. Welsh-English bilingual participants and English controls were presented with a variant of the oddball paradigm involving picture-word pairs. The language of ...


    pub_type: 杂志文章


    authors: Kuipers JR,Thierry G

    更新日期:2010-05-01 00:00:00

  • State anxiety biases estimates of uncertainty and impairs reward learning in volatile environments.

    abstract::Clinical and subclinical (trait) anxiety impairs decision making and interferes with learning. Less understood are the effects of temporary anxious states on learning and decision making in healthy populations, and whether these can serve as a model for clinical anxiety. Here we test whether anxious states in healthy ...


    pub_type: 杂志文章


    authors: Hein TP,de Fockert J,Ruiz MH

    更新日期:2021-01-01 00:00:00

  • Deep brain stimulation in the caudal zona incerta modulates the sensorimotor cerebello-cerebral circuit in essential tremor.

    abstract::Essential tremor is effectively treated with deep brain stimulation (DBS), but the neural mechanisms underlying the treatment effect are poorly understood. Essential tremor is driven by a dysfunctional cerebello-thalamo-cerebral circuit resulting in pathological tremor oscillations. DBS is hypothesised to interfere wi...


    pub_type: 杂志文章


    authors: Awad A,Blomstedt P,Westling G,Eriksson J

    更新日期:2020-04-01 00:00:00

  • Intrinsic functional network architecture of human semantic processing: Modules and hubs.

    abstract::Semantic processing entails the activation of widely distributed brain areas across the temporal, parietal, and frontal lobes. To understand the functional structure of this semantic system, we examined its intrinsic functional connectivity pattern using a database of 146 participants. Focusing on areas consistently a...


    pub_type: 杂志文章


    authors: Xu Y,Lin Q,Han Z,He Y,Bi Y

    更新日期:2016-05-15 00:00:00

  • A comparative analysis of mouse and human medial geniculate nucleus connectivity: a DTI and anterograde tracing study.

    abstract::Understanding the function and connectivity of thalamic nuclei is critical for understanding normal and pathological brain function. The medial geniculate nucleus (MGN) has been studied mostly in the context of auditory processing and its connection to the auditory cortex. However, there is a growing body of evidence ...


    pub_type: 杂志文章


    authors: Keifer OP Jr,Gutman DA,Hecht EE,Keilholz SD,Ressler KJ

    更新日期:2015-01-15 00:00:00

  • Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease.

    abstract:OBJECTIVE:Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). METHODS:We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) a...


    pub_type: 杂志文章


    authors: Vemuri P,Senjem ML,Gunter JL,Lundt ES,Tosakulwong N,Weigand SD,Borowski BJ,Bernstein MA,Zuk SM,Lowe VJ,Knopman DS,Petersen RC,Fox NC,Thompson PM,Weiner MW,Jack CR Jr,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2015-06-01 00:00:00

  • Stochastic synchronization of dynamics on the human connectome.

    abstract::Synchronization is a collective mechanism by which oscillatory networks achieve their functions. Factors driving synchronization include the network's topological and dynamical properties. However, how these factors drive the emergence of synchronization in the presence of potentially disruptive external inputs like s...


    pub_type: 杂志文章


    authors: Pang JC,Gollo LL,Roberts JA

    更新日期:2021-01-14 00:00:00

  • Brain extraction on MRI scans in presence of diffuse glioma: Multi-institutional performance evaluation of deep learning methods and robust modality-agnostic training.

    abstract::Brain extraction, or skull-stripping, is an essential pre-processing step in neuro-imaging that has a direct impact on the quality of all subsequent processing and analyses steps. It is also a key requirement in multi-institutional collaborations to comply with privacy-preserving regulations. Existing automated method...


    pub_type: 杂志文章


    authors: Thakur S,Doshi J,Pati S,Rathore S,Sako C,Bilello M,Ha SM,Shukla G,Flanders A,Kotrotsou A,Milchenko M,Liem S,Alexander GS,Lombardo J,Palmer JD,LaMontagne P,Nazeri A,Talbar S,Kulkarni U,Marcus D,Colen R,Davatzikos

    更新日期:2020-10-15 00:00:00

  • Dissociating prefrontal and parietal cortex activation during arithmetic processing.

    abstract::Lesion and brain-imaging studies have implicated the prefrontal and parietal cortices in arithmetic processing, but do not exclude the possibility that these brain areas are also involved in nonarithmetic operations. In the present study, we used functional magnetic resonance imaging to explore which brain areas contr...


    pub_type: 杂志文章


    authors: Menon V,Rivera SM,White CD,Glover GH,Reiss AL

    更新日期:2000-10-01 00:00:00

  • Motion artifacts in functional near-infrared spectroscopy: a comparison of motion correction techniques applied to real cognitive data.

    abstract::Motion artifacts are a significant source of noise in many functional near-infrared spectroscopy (fNIRS) experiments. Despite this, there is no well-established method for their removal. Instead, functional trials of fNIRS data containing a motion artifact are often rejected completely. However, in most experimental c...


    pub_type: 杂志文章


    authors: Brigadoi S,Ceccherini L,Cutini S,Scarpa F,Scatturin P,Selb J,Gagnon L,Boas DA,Cooper RJ

    更新日期:2014-01-15 00:00:00

  • Detecting white matter activity using conventional 3 Tesla fMRI: An evaluation of standard field strength and hemodynamic response function.

    abstract::Detection of functional magnetic resonance imaging (fMRI) activation in white matter has been increasingly reported despite historically being controversial. Much of the development work to-date has used high-field 4 T MRI and specialized pulse sequences. In the current study, we utilized conventional 3 T MRI and a co...


    pub_type: 杂志文章


    authors: Courtemanche MJ,Sparrey CJ,Song X,MacKay A,D'Arcy RCN

    更新日期:2018-04-01 00:00:00

  • Addendum to “Waxholm Space atlas of the Sprague Dawley rat brain” [NeuroImage 97 (2014) 374-386].

    abstract::The main focus of our original article was to describe the anatomical delineations constituting the first version of the WHS Sprague Dawley atlas, apply the Waxholm Space coordinate system, and publish the associated MRI/DTI template and segmentation volume in their original format. To increase usability of the datase...


    pub_type: 评论,杂志文章


    authors: Papp EA,Leergaard TB,Calabrese E,Johnson GA,Bjaalie JG

    更新日期:2015-01-15 00:00:00

  • Fast optical signal not detected in awake behaving monkeys.

    abstract::While the ability of near-infrared spectroscopy (NIRS) to measure cerebral hemodynamic evoked responses (slow optical signal) is well established, its ability to measure non-invasively the 'fast optical signal' is still controversial. Here, we aim to determine the feasibility of performing NIRS measurements of the 'fa...


    pub_type: 杂志文章


    authors: Radhakrishnan H,Vanduffel W,Deng HP,Ekstrom L,Boas DA,Franceschini MA

    更新日期:2009-04-01 00:00:00

  • Effects of background suppression on the sensitivity of dual-echo arterial spin labeling MRI for BOLD and CBF signal changes.

    abstract::Dual-echo arterial spin labeling (DE-ASL) enables the simultaneous acquisition of BOLD and CBF fMRI data and is often used for calibrated BOLD and cerebrovascular CO2 reactivity measurements. DE-ASL, like all ASL techniques, suffers from a low intrinsic CBF SNR, which can be improved by suppressing the background sign...


    pub_type: 杂志文章


    authors: Ghariq E,Chappell MA,Schmid S,Teeuwisse WM,van Osch MJP

    更新日期:2014-12-01 00:00:00

  • Brain imaging signatures of the relationship between epidermal nerve fibers and heat pain perception.

    abstract::Although the small-diameter primary afferent fibers in the skin promptly respond to nociceptive stimuli and convey sensory inputs to the central nervous system, the neural signatures that underpin the relationship between cutaneous afferent fibers and pain perception remain elusive. We combined skin biopsy at the late...


    pub_type: 杂志文章


    authors: Tseng MT,Kong Y,Chiang MC,Chao CC,Tseng WY,Hsieh ST

    更新日期:2015-11-15 00:00:00

  • Priming of visual cortex by temporal attention? The effects of temporal predictability on stimulus(-specific) processing in early visual cortical areas.

    abstract::In recent studies it has been shown that temporal predictability of expected events alters processing in perception and action. Yet, the neural mechanism(s) by which temporal predictability biases this processing is to date little understood. Therefore, in the present fMRI study we investigated how temporal predictabi...


    pub_type: 杂志文章


    authors: Fischer R,Plessow F,Ruge H

    更新日期:2013-02-01 00:00:00

  • Perceptual similarity of visual patterns predicts dynamic neural activation patterns measured with MEG.

    abstract::Perceptual similarity is a cognitive judgment that represents the end-stage of a complex cascade of hierarchical processing throughout visual cortex. Previous studies have shown a correspondence between the similarity of coarse-scale fMRI activation patterns and the perceived similarity of visual stimuli, suggesting t...


    pub_type: 杂志文章


    authors: Wardle SG,Kriegeskorte N,Grootswagers T,Khaligh-Razavi SM,Carlson TA

    更新日期:2016-05-15 00:00:00

  • Dorsal stream development in motion and structure-from-motion perception.

    abstract::Little is known about the neural development underlying high order visual perception. For example, in detection of structures by coherently moving dots, motion information must interact with shape-based information to enable object recognition. Tasks involving these different motion-based discriminations are known to ...


    pub_type: 杂志文章


    authors: Klaver P,Lichtensteiger J,Bucher K,Dietrich T,Loenneker T,Martin E

    更新日期:2008-02-15 00:00:00

  • Autobiographical memory retrieval in patients with Alzheimer's disease.

    abstract::With aging, the content of self-reported autobiographical memories shifts from episodic to semantic. Onset of Alzheimer's disease enhances this pattern, but the neural underpinnings of this change in Autobiographical Memory (AM), in particular the role of hippocampal degradation, are unknown. We employed fMRI contrast...


    pub_type: 杂志文章


    authors: Meulenbroek O,Rijpkema M,Kessels RP,Rikkert MG,Fernández G

    更新日期:2010-10-15 00:00:00