Abstract:
:A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Yuasa M,Oyaizu K,Horiuchi A,Ogata A,Hatsugai T,Yamaguchi A,Kawakami Hdoi
10.1021/mp049936vkeywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
387-9issue
5eissn
1543-8384issn
1543-8392journal_volume
1pub_type
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