Abstract：
:The basal forebrain cholinergic system is a critical component of the neurobiological substrates underlying attentional function. Orexin neurons are important for arousal and maintenance of wakefulness and are found in the area of the hypothalamus previously shown to project to the basal forebrain. We used dual-probe in vivo microdialysis in rats to test the hypothesis that orexin A (OxA) increases cortical acetylcholine (ACh) release. Intrabasalis administration of OxA (0, 0.1, 10.0 microM via reverse dialysis) dose-dependently increased ACh release within the prefrontal cortex (PFC). In a separate group of animals, local (intra-PFC) administration of OxA via reverse dialysis was found to have no significant effect on ACh release. In order to obtain anatomical corroboration of the basal forebrain as a site of orexin modulation of corticopetal cholinergic activity, we used immunohistochemistry to examine the relationship between orexin fibers and cholinergic neurons in the basal forebrain. We observed widespread distribution of orexin-immunoreactive fibers in cholinergic regions of the basal forebrain, particularly in more rostral areas where frequent instances of apparent appositional contact were observed between orexin fibers and choline acetyltransferase-positive cell bodies. Collectively, these data suggest that orexin projections to the basal forebrain form an important link between hypothalamic arousal and forebrain attentional systems.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Fadel J,Pasumarthi R,Reznikov LRdoi
10.1016/j.neuroscience.2004.09.050keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
541-7issue
2eissn
0306-4522issn
1873-7544pii
S0306-4522(04)00921-2journal_volume
130pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Neuropeptide Y is the most abundant peptide in the mammalian central nervous system and exhibits a variety of potent neurobiological functions. In the present study, double immunolabelling histochemistry was performed, using previously characterized antibodies against neuropeptide Y and the neuropeptide Y Y1 receptor ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00089-x
更新日期：1998-10-01 00:00:00
abstract：:We have recently reported on the efficacy of an NK1 tachykinin receptor antagonist in improving outcome following stroke, including reduced blood-brain barrier (BBB) disruption, reduced cerebral edema and improved functional outcome. The clinically approved stroke treatment, tissue plasminogen activator (tPA), has bee...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2012.06.047
更新日期：2012-09-18 00:00:00
abstract：:Axonal growth requires insertion of newly synthesized membrane components into the plasmalemma. Imbalance between exocytotic membrane addition and endocytic retrieval at specific axonal sites may lead to the bulk plasma membrane flow along the axon and, thus, contribute to the renewal of plasma membrane components. By...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00022-1
更新日期：2000-01-01 00:00:00
abstract：:The cross-sectional areas and succinate dehydrogenase activities of L5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight an...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00097-3
更新日期：1997-11-01 00:00:00
abstract：:Creatine supplementation has been shown to protect neurons from oxidative damage due to its antioxidant and ergogenic functions. These features have led to the hypothesis of creatine supplementation use during pregnancy as prophylactic treatment to prevent CNS damage, such as hypoxic-ischemic encephalopathy. Unfortuna...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.11.017
更新日期：2016-01-15 00:00:00
abstract：:The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2017.06.043
更新日期：2017-09-17 00:00:00
abstract：:Acute ambient hypoxia interacts with the ventilatory and cardiocirculatory control systems, via the concomitant activation of arterial chemoreceptors and tissue oxygen-sensing mechanisms. Whether these latter mechanisms may trigger a specific pathway had not yet been elucidated. We addressed this issue, mapping Fos ex...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00442-0
更新日期：2001-01-01 00:00:00
abstract：:In the dog cerebral cortex and spinal cord, [3H]bremazocine and [3H]U69593 both bound with high affinity to an apparent single population of binding sites under kappa-selective conditions. In the cortex similar Bmax values for both radioligands in the saturation studies and the high affinity of the kappa-selective age...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(89)90437-5
更新日期：1989-01-01 00:00:00
abstract：:In order to study structural alterations which occur after a defined unilateral cortical infarct, the hindlimb region of the rat cortex was photochemically lesioned. The infarcts caused edema restricted to the perilesional cortex which affected allocortical and isocortical areas differently. Postlesional changes in cy...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00289-3
更新日期：1998-01-01 00:00:00
abstract：:It has previously been reported that the avian H5N1 type of influenza A virus can be detected in neurons and astrocytes of human brains in autopsy cases. However, the underlying neuropathogenicity remains unexplored. In this study, we used differentiated human astrocytic and neuronal cell lines as models to examine th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.04.013
更新日期：2010-07-14 00:00:00
abstract：:Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.08.075
更新日期：2006-01-01 00:00:00
abstract：:Neurons lying in the white matter of the upper cervical spinal cord become transneuronally labelled following pseudorabies virus injections into the kidney or stellate ganglion, suggesting that they project directly to sympathetic preganglionic neurons. In the present study, we extend these findings and report here th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)86660-2
更新日期：1997-04-01 00:00:00
abstract：:Rats received bilateral lesions of the nucleus basalis magnocellularis by infusion of ibotenic acid. Fourteen days later, osmotic minipumps releasing human recombinant nerve growth factor (0.3 micrograms/day) were implanted subcutaneously. Starting one month after the lesion, spatial learning of the animals was tested...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90342-y
更新日期：1992-01-01 00:00:00
abstract：:The aim of this study was to determine whether forebrain neurons projecting to the mediodorsal nucleus of the thalamus in rats express glutamate decarboxylase messenger RNA as a marker for GABAergic neurons. Forebrain glutamate decarboxylase messenger RNA-containing neurons that project to the mediodorsal nucleus were...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00351-i
更新日期：1996-01-01 00:00:00
abstract：:In the adult CNS, tissue-specific germinal niches, such as the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus, contain multipotent neural precursor cells (NPCs) with the capacity to self-renew and differentiate into functional brain cells (i.e. neurons, a...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2013.07.022
更新日期：2013-10-10 00:00:00
abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.03.037
更新日期：2011-06-02 00:00:00
abstract：:The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00568-5
更新日期：1999-01-01 00:00:00
abstract：:Traumatic brain injury (TBI) is a major cause of morbidity and mortality world-wide and can result in persistent cognitive, sensory and behavioral dysfunction. Understanding the time course of TBI-induced pathology is essential to effective treatment outcomes. We induced TBI in rats using an impact acceleration method...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.08.018
更新日期：2016-10-15 00:00:00
abstract：:Successive fusion events between transport vesicles and their target membranes mediate trafficking of secreted, membrane- and organelle-localised proteins. During the initial steps of this process, termed the secretory pathway, COPII vesicles bud from the endoplasmic reticulum (ER) and fuse with the cis-Golgi membrane...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2019.03.057
更新日期：2019-11-10 00:00:00
abstract：:Cholinergic interneurons, which provide the main source of acetylcholine (ACh) in the striatum, control the striatal local circuits and deeply involve in the pathogenesis of neurodegenerative diseases. Glycogen synthase kinase-3 (GSK-3) is a crucial kinase with diverse fundamental functions and accepted that deregulat...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2013.10.001
更新日期：2013-01-01 00:00:00
abstract：:Dysfunction of thalamo-cortical networks involving particularly the thalamic reticular nucleus (TRN) is implicated in schizophrenia. In the neonatal ventral hippocampal lesion (NVHL), a heuristic animal model of schizophrenia, brain oscillation changes similar to those of schizophrenic patients have been reported. The...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2017.05.035
更新日期：2017-08-15 00:00:00
abstract：:The distribution and staining pattern of gamma-aminobutyric acid immunoreactivity have been examined by both light and electron microscopy in the dorsal part of the lateral geniculate nucleus of three reptilian species: the turtle Chinemys reevesi, the lizard Ophisaurus apodus and the snake Vipera aspis. After perfusi...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90254-y
更新日期：1992-01-01 00:00:00
abstract：:Combining gene expression data with morphological information has revolutionized developmental neuroanatomy in the last decade. Visualization and interpretation of complex images have been crucial to these advances in our understanding of mechanisms underlying early brain development, as most developmental processes a...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.06.093
更新日期：2005-01-01 00:00:00
abstract：:The nucleus accumbens is considered to be critically involved in the control of complex motivated behaviors. By modulating its glutamatergic excitatory input, mesolimbic dopaminergic afferents have been implicated in the reinforcing properties of drugs of abuse. However, they might not represent the only path for infl...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00372-4
更新日期：2001-01-01 00:00:00
abstract：:Studies with animal seizure models have indicated that changes in temporal and spatial expression of voltage-gated sodium channels may be important in the pathology of epilepsy. Here, by using in situ hybridisation with previously characterised subtype-selective oligonucleotide probes [Whitaker et al. (2000) J. Comp. ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00212-3
更新日期：2001-01-01 00:00:00
abstract：:The sigma1 (sigma 1) receptor agonists exert potent anti-amnesic effects, as they apparently block the learning impairments either induced by the muscarinic receptor antagonist scopolamine, the N-methyl-D-aspartate receptor antagonist dizocilpine or inherently due to the age-related deficits in senescence-accelerated ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00405-3
更新日期：1998-03-01 00:00:00
abstract：:The occurrence of neuropeptide Y-like immunoreactivity in the adrenal gland was investigated by means of radioimmunoassay, chromatography and immunohistochemistry. The adrenal levels of neuropeptide Y-like immunoreactivity varied considerably between species with lowest amounts in the rat and highest in the cow where ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(86)90313-1
更新日期：1986-11-01 00:00:00
abstract：:The clock gene protein Per 1 (PER1) is expressed in several brain structures and oscillates associated with the suprachiasmatic nucleus (SCN). Restricted feeding schedules (RFS) induce anticipatory activity and impose daily oscillations of c-Fos and clock proteins in brain structures. Daily access to a palatable treat...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2008.06.001
更新日期：2008-07-31 00:00:00
abstract：:The glucocorticoid-induced receptor (GIR) is an orphan G-protein-coupled receptor awaiting pharmacological characterization. GIR was originally identified in murine thymoma cells, and shows a widespread, yet not completely complementary distribution in mouse and human brain. Expression of the mouse GIR gene is modulat...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.01.066
更新日期：2005-01-01 00:00:00
abstract：:Spreading depression (SD) is a wave of coordinated cellular depolarization that propagates slowly throughout brain tissue. SD has been associated with migraine aura, and related events have been implicated in the enlargement of some brain injuries. Selective disruption of astrocyte oxidative metabolism has previously ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.05.006
更新日期：2011-09-29 00:00:00
