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Toward a pharmacophore for kinase frequent hitters.

Abstract：

:Small molecule protein kinase inhibitors are widely employed as biological reagents and as leads in the design of drugs for a variety of diseases. One of the hardest challenges in kinase inhibitor design is achieving target selectivity. By utilizing X-ray structural information for four promiscuous inhibitors, we propose a five-point pharmacophore for kinase frequent hitters, demonstrate its ability to discriminate between frequent hitters and selective ligands, and suggest a strategy for selective inhibitor design.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Aronov AM,Murcko MA

doi

10.1021/jm049793g

keywords:

subject

Has Abstract

pub_date

2004-11-04 00:00:00

pages

5616-9

issue

23

eissn

0022-2623

issn

1520-4804

journal_volume

47

pub_type

杂志文章

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