Evidence for positive selection on Mycobacterium tuberculosis within patients.

Abstract:

BACKGROUND:While the pathogenesis and epidemiology of tuberculosis are well studied, relatively little is known about the evolution of the infectious agent Mycobacterium tuberculosis, especially at the within-host level. The insertion sequence IS6110 is a genetic marker that is widely used to track the transmission of tuberculosis between individuals. This and other markers may also facilitate our understanding of the disease within patients. RESULTS:This article presents three lines of evidence supporting the action of positive selection on M. tuberculosis within patients. The arguments are based on a comparison between empirical findings from molecular epidemiology, and population genetic models of evolution. Under the hypothesis of neutrality of genotypes, 1) the mutation rate of the marker IS6110 is unusually high, 2) the time it takes for substitutions to occur within patients is too short, and 3) the amount of polymorphism within patients is too low. CONCLUSIONS:Empirical observations are explained by the action of positive selection during infection, or alternatively by very low effective population sizes. I discuss the possible roles of antibiotic treatment, the host immune system and extrapulmonary dissemination in creating opportunities for positive selection.

journal_name

BMC Evol Biol

journal_title

BMC evolutionary biology

authors

Tanaka MM

doi

10.1186/1471-2148-4-31

keywords:

subject

Has Abstract

pub_date

2004-09-09 00:00:00

pages

31

issn

1471-2148

pii

1471-2148-4-31

journal_volume

4

pub_type

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