Abstract:
BACKGROUND:While the pathogenesis and epidemiology of tuberculosis are well studied, relatively little is known about the evolution of the infectious agent Mycobacterium tuberculosis, especially at the within-host level. The insertion sequence IS6110 is a genetic marker that is widely used to track the transmission of tuberculosis between individuals. This and other markers may also facilitate our understanding of the disease within patients. RESULTS:This article presents three lines of evidence supporting the action of positive selection on M. tuberculosis within patients. The arguments are based on a comparison between empirical findings from molecular epidemiology, and population genetic models of evolution. Under the hypothesis of neutrality of genotypes, 1) the mutation rate of the marker IS6110 is unusually high, 2) the time it takes for substitutions to occur within patients is too short, and 3) the amount of polymorphism within patients is too low. CONCLUSIONS:Empirical observations are explained by the action of positive selection during infection, or alternatively by very low effective population sizes. I discuss the possible roles of antibiotic treatment, the host immune system and extrapulmonary dissemination in creating opportunities for positive selection.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Tanaka MMdoi
10.1186/1471-2148-4-31keywords:
subject
Has Abstractpub_date
2004-09-09 00:00:00pages
31issn
1471-2148pii
1471-2148-4-31journal_volume
4pub_type
杂志文章abstract:BACKGROUND:Specific host-parasite systems often embody a particular co-distribution phenomenon, in which the parasite's phylogeographic pattern is dependent on its host. In practice, however, both congruent and incongruent phylogeographic patterns between the host and the parasite have been reported. Here, we compared ...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2009-06-28 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-29 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-06 00:00:00
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pub_type: 杂志文章
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更新日期:2005-11-08 00:00:00
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journal_title:BMC evolutionary biology
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pub_type: 杂志文章
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