Abstract：
BACKGROUND:Prior to the sequencing of the human genome it was typically assumed that, tandem duplication aside, gene order is for the most part random. Numerous observers, however, highlighted instances in which a ligand was linked to one of its cognate receptors, with some authors suggesting that this may be a general and/or functionally important pattern, possibly associated with recombination modification between epistatically interacting loci. Here we ask whether ligands are more closely linked to their receptors than expected by chance. RESULTS:We find no evidence that ligands are linked to their receptors more closely than expected by chance. However, in the human genome there are approximately twice as many co-occurrences of ligand and receptor on the same human chromosome as expected by chance. Although a weak effect, the latter might be consistent with a past history of block duplication. Successful duplication of some ligands, we hypothesise, is more likely if the cognate receptor is duplicated at the same time, so ensuring appropriate titres of the two products. CONCLUSION:While there is an excess of ligands and their receptors on the same human chromosome, this cannot be accounted for by classical models of non-random gene order, as the linkage of ligands/receptors is no closer than expected by chance. Alternative hypotheses for non-random gene order are hence worth considering.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Hurst LD,Lercher MJdoi
10.1186/1471-2148-5-62keywords:
subject
Has Abstractpub_date
2005-11-08 00:00:00pages
62issn
1471-2148pii
1471-2148-5-62journal_volume
5pub_type
杂志文章abstract：BACKGROUND:Although most insect species are specialized on one or few groups of plants, there are phytophagous insects that seem to use virtually any kind of plant as food. Understanding the nature of this ability to feed on a wide repertoire of plants is crucial for the control of pest species and for the elucidation ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-016-0627-y
更新日期：2016-03-08 00:00:00
abstract：BACKGROUND:Moths have evolved highly successful mating systems, relying on species-specific mixtures of sex pheromone components for long-distance mate communication. Acyl-CoA desaturases are key enzymes in the biosynthesis of these compounds and to a large extent they account for the great diversity of pheromone struc...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-8-270
更新日期：2008-10-02 00:00:00
abstract：BACKGROUND:Lepidosauria (lizards, snakes, tuatara) is a globally distributed and ecologically important group of over 9,000 reptile species. The earliest fossil records are currently restricted to the Late Triassic and often dated to 227 million years ago (Mya). As these early records include taxa that are relatively d...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-13-208
更新日期：2013-09-25 00:00:00
abstract：BACKGROUND:The var genes of the human malaria parasite Plasmodium falciparum are highly polymorphic loci coding for the erythrocyte membrane proteins 1 (PfEMP1), which are responsible for the cytoaherence of P. falciparum infected red blood cells to the human vasculature. Cytoadhesion, coupled with differential express...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-13-110
更新日期：2013-05-31 00:00:00
abstract：BACKGROUND:DNA sequences afford access to the evolutionary pathways of life. Particularly mobile elements that constantly co-evolve in genomes encrypt recent and ancient information of their host's history. In mammals there is an extraordinarily abundant activity of mobile elements that occurs in a dynamic succession o...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-10-376
更新日期：2010-12-02 00:00:00
abstract：BACKGROUND:The reproductive ground plan hypothesis of social evolution suggests that reproductive controls of a solitary ancestor have been co-opted during social evolution, facilitating the division of labor among social insect workers. Despite substantial empirical support, the generality of this hypothesis is not un...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-11-95
更新日期：2011-04-13 00:00:00
abstract：BACKGROUND:A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases where the level of gene pro...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-9-193
更新日期：2009-08-07 00:00:00
abstract：BACKGROUND:Function prediction by transfer of annotation from the top database hit in a homology search has been shown to be prone to systematic error. Phylogenomic analysis reduces these errors by inferring protein function within the evolutionary context of the entire family. However, accuracy of function prediction ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-7-S1-S12
更新日期：2007-02-08 00:00:00
abstract：BACKGROUND:There is wide agreement that only a subset of the twenty standard amino acids existed prebiotically in sufficient concentrations to form functional polypeptides. We ask how this subset, postulated as {A,D,E,G,I,L,P,S,T,V}, could have formed structures stable enough to found metabolic pathways. Inspired by al...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1464-6
更新日期：2019-07-30 00:00:00
abstract：BACKGROUND:Coevolution is a selective process of reciprocal adaptation in hosts and parasites or in mutualistic symbionts. Classic population genetics theory predicts the signatures of selection at the interacting loci of both species, but not the neutral genome-wide polymorphism patterns. To bridge this gap, we build ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1556-3
更新日期：2019-12-19 00:00:00
abstract：BACKGROUND:A comprehensive evolutionary analysis of bacterial genomes implies to identify the hallmark of vertical and non-vertical signals and to discriminate them from the presence of mere phylogenetic noise. In this report we have addressed the impact of factors like the universal distribution of the genes, their es...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-7-S1-S7
更新日期：2007-02-08 00:00:00
abstract：BACKGROUND:Complete mitochondrial genome sequences have become important tools for the study of genome architecture, phylogeny, and molecular evolution. Despite the rapid increase in available mitogenomes, the taxonomic sampling often poorly reflects phylogenetic diversity and is often also biased to represent deeper (...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-10-300
更新日期：2010-10-07 00:00:00
abstract：BACKGROUND:Recent models suggest that escalating reciprocal selection among antagonistically interacting species is predicted to occur in areas of higher resource productivity. In a putatively coevolved interaction between a freshwater snail (Mexipyrgus churinceanus) and a molluscivorous cichlid (Herichthys minckleyi),...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-7-50
更新日期：2007-03-30 00:00:00
abstract：:Recently, a set of publications described flea fossils from Jurassic and Early Cretaceous geological strata in northeastern China, which were suggested to have parasitized feathered dinosaurs, pterosaurs, and early birds or mammals. In support of these fossils being fleas, a recent publication in BMC Evolutionary Biol...
journal_title：BMC evolutionary biology
pub_type： 信件
doi：10.1186/s12862-015-0568-x
更新日期：2016-01-11 00:00:00
abstract：BACKGROUND:Evolutionary transitions from terrestrial to aquatic life history cause drastic changes in sensory systems. Indeed, the drastic changes in vision have been reported in many aquatic amniotes, convergently. Recently, the opsin genes of the full-aquatic sea snakes have been reported. However, those of the amphi...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-020-01725-1
更新日期：2020-11-26 00:00:00
abstract：BACKGROUND:Maternally inherited endosymbionts like Wolbachia pipientis are in linkage disequilibrium with the mtDNA of their hosts. Therefore, they can induce selective sweeps, decreasing genetic diversity over many generations. This sex ratio distorter, that is involved in the origin of parthenogenesis and other repro...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-10-340
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:The filamentous fungus Ashbya gossypii grows into a multicellular mycelium that is distinct from the unicellular morphology of its closely related yeast species. It has been proposed that genes important for cell cycle regulation play central roles for such phenotypic differences. Because A. gossypii shares ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-8-343
更新日期：2008-12-29 00:00:00
abstract：BACKGROUND:The functional repertoire of the human proteome is an incremental collection of functions accomplished by protein domains evolved along the Homo sapiens lineage. Therefore, knowledge on the origin of these functionalities provides a better understanding of the domain and protein evolution in human. The lack ...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-6-91
更新日期：2006-11-07 00:00:00
abstract：BACKGROUND:Partitioning involves estimating independent models of molecular evolution for different subsets of sites in a sequence alignment, and has been shown to improve phylogenetic inference. Current methods for estimating best-fit partitioning schemes, however, are only computationally feasible with datasets of fe...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-14-82
更新日期：2014-04-17 00:00:00
abstract：BACKGROUND:Drosophila melanogaster often shows correlations between latitude and phenotypic or genetic variation on different continents, which suggests local adaptation with respect to a heterogeneous environment. Previous phenotypic analyses of latitudinal clines have investigated mainly physiological, morphological,...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-015-0316-2
更新日期：2015-03-13 00:00:00
abstract：BACKGROUND:Marine invertebrates are abundant and diverse on the continental shelf in Antarctica, but little is known about their parasitic counterparts. Endoparasites are especially understudied because they often possess highly modified body plans that pose problems for their identification. Asterophila, a genus of en...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1499-8
更新日期：2019-09-18 00:00:00
abstract：BACKGROUND:Protein sequence evolution is constrained by the biophysics of folding and function, causing interdependence between interacting sites in the sequence. However, current site-independent models of sequence evolutions do not take this into account. Recent attempts to integrate the influence of structure and bi...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-11-361
更新日期：2011-12-16 00:00:00
abstract：BACKGROUND:Hotspots of angiosperm species richness and endemism in Mediterranean-climate regions are among the most striking, but least well-understood, geographic patterns of biodiversity. Recent studies have emphasized the importance of rapid diversification within hotspots, compared to non-hotspot regions, as a majo...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-13-155
更新日期：2013-08-19 00:00:00
abstract：BACKGROUND:Many pathologies that modify the shell geometry and ornamentation of ammonoids are known from the fossil record. Since they may reflect the developmental response of the organism to a perturbation (usually a sublethal injury), their study is essential for exploring the developmental mechanisms of these extin...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1538-5
更新日期：2019-11-13 00:00:00
abstract：BACKGROUND:The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications. In human, 10 members exist and sequence and functional homologues and ligand-...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-10-135
更新日期：2010-05-06 00:00:00
abstract：BACKGROUND:ADP-glucose pyrophosphorylase (AGPase), which catalyses a rate limiting step in starch synthesis, is a heterotetramer comprised of two identical large and two identical small subunits in plants. Although the large and small subunits are equally sensitive to activity-altering amino acid changes when expressed...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-8-232
更新日期：2008-08-12 00:00:00
abstract：BACKGROUND:Speciation often occurs in complex or uncertain temporal and spatial contexts. Processes such as reinforcement, allopatric divergence, and assortative mating can proceed at different rates and with different strengths as populations diverge. The Central American Midas cichlid fish species complex is an impor...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/1471-2148-7-25
更新日期：2007-02-20 00:00:00
abstract：BACKGROUND:The Scalidophora (Kinorhyncha, Loricifera and Priapulida) have an important phylogenetic position as early branching ecdysozoans, yet the architecture of their nervous organ systems is notably underinvestigated. Without such information, and in the absence of a stable phylogenetic context, we are inhibited f...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1405-4
更新日期：2019-04-08 00:00:00
abstract：BACKGROUND:Most fatty acids (FAs) making up the adipose tissue in mammals have a dietary origin and suffer little modification when they are stored. However, we propose that some of those FAs, specifically those that can be synthesised or modified by mammals, are also being influenced by thermal forces and used as part...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-019-1473-5
更新日期：2019-07-26 00:00:00
abstract：BACKGROUND:Opsins are the only class of proteins used for light perception in image-forming eyes. Gene duplication and subsequent functional divergence of opsins have played an important role in expanding photoreceptive capabilities of organisms by altering what wavelengths of light are absorbed by photoreceptors (spec...
journal_title：BMC evolutionary biology
pub_type： 杂志文章
doi：10.1186/s12862-016-0823-9
更新日期：2016-11-17 00:00:00
