High titer retroviral gene transduction to neural progenitor cells for establishment of donor cells for neural transplantation to parkinsonian model rats.

Abstract:

:Neural progenitor cells (NPCs) are expected to be useful donor sources for cell transplantation therapy in Parkinson's disease. However, control of the differentiational lineage, especially into dopaminergic neurons, is still difficult. Thus, genetic modification of NPCs to produce l-dopa is potentially useful. The present study prepared high titer retrovirus carrying human tyrosine hydroxylase-1 (HTH-1) gene. HTH-1 gene could be efficiently transduced into NPCs obtained from the E12.5 rat mesencephalon. This retroviral gene transduction caused no apparent changes in survival, proliferation, or differentiation. In vitro, HTH-1 gene-transduced NPCs released little l-dopa and addition of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, was required for production of l-dopa. In vivo, three of seven hemi-parkinsonian model rats that received HTH-1 gene-transduced donor NPCs achieved functional recovery. High titer retroviral vector for gene transduction could be used to prepare NPCs for transplantation to hemi-parkinsonian model rats. However, functional recovery after transplantation of HTH-1 gene-transduced NPCs was incomplete.

authors

Kodama Y,Hida H,Jung CG,Baba H,Isono M,Kobayashi H,Nishino H

doi

10.2176/nmc.44.344

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

344-51; discussion 352

issue

7

eissn

0470-8105

issn

1349-8029

pii

JST.JSTAGE/nmc/44.344

journal_volume

44

pub_type

杂志文章
  • Cerebellar abscess associated with pulmonary arteriovenous fistula and hereditary hemorrhagic telangiectasia--case report.

    abstract::A 57-year-old male with a past history of bilateral pulmonary arteriovenous fistulas (PAVFs) experienced a sudden onset of headache and gait disturbance. There was a family history of PAVF and recurrent epistaxis. He had diffuse telangiectasia of the tongue, and hereditary hemorrhagic telangiectasia was diagnosed. Neu...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.36.575

    authors: Ogino M,Inoue H,Harada S,Horinouchi H,Nakamura T

    更新日期:1996-08-01 00:00:00

  • [The usefulness of lumbar epidural pressure as an index of intracranial pressure].

    abstract::The reliability of lumbar intraspinal epidural pressure (ISEDP) as an index of intracranial pressure was investigated in seven patients with high intracranial pressure following neurosurgery. ISEDP and intracranial epidural pressure (ICEDP) were measured simultaneously, the latter by the conventional method. ISEDP was...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.29.484

    authors: Fujioka S,Kaku M,Hamada J,Yokota A,Ushio Y

    更新日期:1989-06-01 00:00:00

  • Large dorsal internal carotid artery aneurysm--report of two cases.

    abstract::Two patients with unusually large dorsal internal carotid artery aneurysms manifesting as subarachnoid hemorrhage are described. Surgery in both cases resulted in intraoperative rupture of the sac. The outcome was poor in the first patient and excellent in the second. The importance of wide exposure of the proximal an...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.33.564

    authors: Diraz A,Kobayashi S,Gibo H,Ohsawa M

    更新日期:1993-08-01 00:00:00

  • Spinal cord glioblastoma multiforme with intracranial dissemination--case report.

    abstract::A case of spinal cord glioblastoma multiforme with intracranial dissemination is reported. A 23-year-old female was admitted to a local hospital complaining of lumbago. Myelography revealed an intramedullary thoracic tumor. The tumor was partially removed through a laminectomy at Th11-L1. The histological diagnosis wa...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.30.489

    authors: Asano N,Kitamura K,Seo Y,Mukai K,Soga T,Hondo H,Matsumoto K

    更新日期:1990-07-01 00:00:00

  • Morphological effects of tumor necrosis factor-alpha on the blood vessels in rat experimental brain tumors.

    abstract::The morphological changes in the vascular endothelium caused by the administration of tumor necrosis factor-alpha (TNF-alpha) were studied in an experimental model of rat brain tumors. Wistar rats bearing implanted C6 glioma received human natural-type TNF-alpha (1.7 x 10(5) U/m2) through the carotid artery and were s...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.36.423

    authors: Isaka T,Yoshimine T,Maruno M,Hayakawa T

    更新日期:1996-07-01 00:00:00

  • Flare up of tuberculous abscess following stereotactic aspiration--case report.

    abstract::A 16-year-old non-immunocompromised and otherwise healthy patient presented with a tuberculous brain abscess. The abscess was aspirated stereotactically. Following the aspiration the disease process flared up and multiple daughter abscess cavities were discovered. The daughter abscesses were removed via craniotomy. St...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.42.147

    authors: Desai K,Bhatjiwale M,Nadkarni T,Goel A

    更新日期:2002-03-01 00:00:00

  • Ruptured anterior communicating artery aneurysm causing bilateral abducens nerve paralyses--case report.

    abstract::A rare case of bilateral abducens nerve paralyses after rupture of an anterior communicating artery (AcoA) aneurysm occurred in a 56-year-old female after sudden onset of severe headache. Bilateral abducens nerve paralyses were present without additional neuro-ophthalmological signs. Computed tomography revealed subar...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.32.17

    authors: Nathal E,Yasui N,Suzuki A,Hadeishi H

    更新日期:1992-01-01 00:00:00

  • Preliminary experience with air transfer of patients for rescue endovascular therapy after failure of intravenous tissue plasminogen activator.

    abstract::The present report describes our experience with air transfer of patients with acute ischemic stroke in whom intravenous tissue plasminogen activator (IV t-PA) failed for rescue endovascular therapy (EVT). Twenty-three consecutive patients in whom IV t-PA failed were transferred to our hospital for rescue EVT between ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.cr.2014-0235

    authors: Tsujimoto M,Yoshimura S,Enomoto Y,Yamada N,Matsumaru N,Kumada K,Toyoda I,Ogura S,Iwama T

    更新日期:2015-01-01 00:00:00

  • Permissible arterial occlusion time in aneurysm surgery: postoperative hyperperfusion caused by temporary clipping.

    abstract::The relationship between hyperperfusion and temporary clipping was evaluated to determine the safe limit for the duration of temporary clipping in aneurysm surgery. Twenty-one patients surgically treated for a ruptured aneurysm were examined using xenon-enhanced computed tomography on postoperative days 4 to 13. Eight...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.39.901

    authors: Araki Y,Andoh H,Yamada M,Nakatani K,Andoh T,Sakai N

    更新日期:1999-12-01 00:00:00

  • Cerebral sinus thrombosis in patient with ulcerative colitis--case report.

    abstract::Left transverse sinus thrombosis developed in a 27-year-old male with ulcerative colitis. The diagnosis was based on cerebral angiography and magnetic resonance (MR) imaging, the latter of which clearly delineated the intraluminal thrombus. Serial MR images demonstrated thrombus organization. The use of this method in...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.32.232

    authors: Moriyama E,Shinohara C,Tokunaga K,Kamitani M,Norikane H,Matsumoto Y,Motoki M

    更新日期:1992-04-01 00:00:00

  • Recurrent brain abscess associated with hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)--case report.

    abstract::A 53-year-old mentally handicapped female with hereditary hemorrhagic telangiectasia complicated by pulmonary arteriovenous fistula developed a recurrent brain abscess in the left frontal region. She responded well to surgical drainage and antibiotic therapy. Previously, she had two brain abscesses of the left parieto...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.32.891

    authors: Kikuchi K,Kowada M,Shioya H,Shioya T

    更新日期:1992-11-01 00:00:00

  • Probable brain abscess presenting as a high uptake lesion on thallium-201 single photon emission computed tomography--case report.

    abstract::A 61-year-old male presented with a brain abscess manifesting as high fever and generalized convulsion attacks. Magnetic resonance (MR) imaging disclosed a ring-like enhanced lesion in the parietal lobe. Thallium-201 single photon emission computed tomography (201Tl SPECT) images demonstrated a high uptake lesion with...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.37.775

    authors: Sato S,Ogasawara K,Kinouchi H,Kohsyu K,Yoshimoto T

    更新日期:1997-10-01 00:00:00

  • Supratentorial primitive neuroectodermal tumor in an aged patient--case report--.

    abstract::An 88-year-old woman presented with a supratentorial primitive neuroectodermal tumor (PNET) manifesting as disturbance of consciousness and left hemiplegia. Magnetic resonance imaging showed a large mass lesion in the right frontotemporal region. She underwent biopsy of the lesion that confirmed the diagnosis of PNET....

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.45.530

    authors: Shingu T,Kagawa T,Kimura Y,Takada D,Moritake K,Hoshii Y

    更新日期:2005-10-01 00:00:00

  • Low-grade astroblastoma recurring with extensive invasion.

    abstract::A 17-year-old male presented with morning headache and double vision. Neuroimaging revealed a lobulated enhanced mass lesion with a blurred margin and remarkable peritumoral edema, and high uptake of methionine. The gray, soft, well-circumscribed mass was grossly totally resected. Histological examination showed the t...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.46.450

    authors: Kaji M,Takeshima H,Nakazato Y,Kuratsu J

    更新日期:2006-09-01 00:00:00

  • Subependymoma in the lateral ventricle manifesting as intraventricular hemorrhage.

    abstract::A 32-year-old man presented with subependymoma in the lateral ventricle causing intraventricular hemorrhage and manifesting as severe headache and disturbance of consciousness. Computed tomography on admission showed a massive intraventricular hemorrhage and acute obstructive hydrocephalus. Cerebral angiography reveal...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.1020

    authors: Akamatsu Y,Utsunomiya A,Suzuki S,Endo T,Suzuki I,Nishimura S,Ezura M,Suzuki H,Uenohara H,Tominaga T

    更新日期:2010-01-01 00:00:00

  • Bypass surgery for occluded internal carotid artery revascularized by vasa vasorum--case report.

    abstract::A 47-year-old woman presented with two transient ischemic attacks due to occlusion of the left internal carotid artery. The affected artery was revascularized by vasa vasorum. Angiography showed occlusion of the left common carotid artery including the origin of the internal carotid artery. The distal internal carotid...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.42.57

    authors: Shimizu H,Tominaga T,Ezura M,Yoshimoto T

    更新日期:2002-02-01 00:00:00

  • Ring-enhanced primary intracranial malignant lymphoma--report of two cases.

    abstract::Two nonimmunosuppressed patients with primary intracranial malignant lymphoma demonstrated ring-enhanced lesion on postcontrast CT scans. One patient underwent total removal of the tumor and the other patient biopsy, both followed by whole brain irradiation. Histological examination revealed the tumors contained diffu...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.31.214

    authors: Tan EC,Wakabayashi S,Kanai H,Nagai H

    更新日期:1991-04-01 00:00:00

  • Endovascular treatment for a unusually large mycotic aneurysm manifesting as intracerebral hemorrhage - case report.

    abstract::A 62-year-old male presented with an unusually large mycotic aneurysm mimicking a saccular aneurysm manifesting as coma and hypotension. Computed tomography showed intracerebral and intraventricular hemorrhage. He was in septic shock due to acute infectious endocarditis. Cerebral angiography disclosed a large distal a...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.46.544

    authors: Hara Y,Hosoda K,Wada T,Kimura H,Kohmura E

    更新日期:2006-11-01 00:00:00

  • Cutting balloon angioplasty for carotid artery in-stent stenosis supported by three-dimensional rotational angiography with automated vessel analysis software.

    abstract::In-stent stenosis is a possible long-term complication of carotid artery stenting. A simple and safe technique of cutting balloon angioplasty is described for carotid in-stent stenosis. The stented vessel is imaged by three-dimensional (3D) rotational angiography, the acquired projection images are transferred to a wo...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.48.235

    authors: Akiyama Y,Moritake K,Miyazaki T,Kowari K,Sato H,Shimada T

    更新日期:2008-05-01 00:00:00

  • Spontaneous thrombosis of intracavernous internal carotid artery aneurysm and parent artery occlusion in patients with positive balloon test occlusion--two case reports.

    abstract::Two patients with giant intracavernous internal carotid artery (ICA) aneurysms were intolerant to balloon test occlusion of the ICA, and later developed spontaneous thrombosis of the aneurysm and the parent ICA without ischemic sequelae. Case 1: A 60-year-old female with a giant right intracavernous ICA aneurysm prese...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.41.436

    authors: Kurokawa R,Kuroshima Y,Yoshida K,Kawase T

    更新日期:2001-09-01 00:00:00

  • A Ruptured Basilar Tip Aneurysm Showing Repeated Perianeurysmal Edema after Endovascular Coil Embolization: Case Report.

    abstract::The authors present an extremely rare case of a 48-year-old female who developed repeated perianeurysmal edema at 2, 9, and 16 weeks after endovascular coil embolization for the ruptured intracranial aneurysm. Interestingly, the mechanism for this edema could be different at each time point in this case; acute thrombo...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.cr.2013-0217

    authors: Takeshita T,Horie N,Fukuda Y,So G,Hayashi K,Morikawa M,Suyama K,Nagata I

    更新日期:2015-01-01 00:00:00

  • Delayed radiation necrosis 7 years after gamma knife surgery for arteriovenous malformation--two case reports.

    abstract::A 44-year-old woman and a 55-year-old woman were treated with gamma knife surgery (GKS) for occipital arteriovenous malformation (AVM). Angiography confirmed complete nidus obliterations 2 years after GKS. However, both patients complained of chronic headache and visual symptoms from around 7 years after GKS. Magnetic...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.62

    authors: Oyoshi T,Hirahara K,Uetsuhara K,Yatsushiro K,Arita K

    更新日期:2010-01-01 00:00:00

  • The pitfalls in surgical management of lumbar canal stenosis associated with rheumatoid arthritis.

    abstract::There have been few clinical studies in the area of cervical spine that focused on surgery for treating degenerative lumbar disease in patients with rheumatoid arthritis (RA). High rates of wound complications and instrumentation failure have been reported more for RA than for non-RA patients, although clinical outcom...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa2012-0299

    authors: Mitsuyama T,Kubota M,Yuzurihara M,Mizuno M,Hashimoto R,Ando R,Okada Y

    更新日期:2013-01-01 00:00:00

  • Perimesencephalic nonaneurysmal subarachnoid hemorrhage with unilateral third cranial nerve palsy: two case reports.

    abstract::Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PNSAH) is a benign form of subarachnoid hemorrhage and is usually not associated with any focal deficit. We describe two rare cases of PNSAH with unilateral third cranial nerve palsy. Both patients were treated conservatively. The outcomes of our two cases were ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.52.918

    authors: Sadamasa N,Sano N,Takeda N,Yoshida K,Narumi O,Chin M,Yamagata S

    更新日期:2012-01-01 00:00:00

  • Uterine leiomyosarcoma metastasis to the skull--case report.

    abstract::A 54-year-old female presented with a rare uterine leiomyosarcoma metastasis to the skull appearing as a gross mass beneath her scalp. She had no neurological or other physical symptoms on admission. Computed tomography and magnetic resonance imaging demonstrated an enhanced dumbbell-shaped mass at the mid-frontal reg...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.36.469

    authors: Uchino M,Endo G,Shibata I,Terao H,Kuramitsu T,Kushida Y,Nakamura N

    更新日期:1996-07-01 00:00:00

  • Ruptured cerebral aneurysm successfully clipped in idiopathic thrombocytopenic purpura after high-dose gamma-globulin therapy--case report.

    abstract::A ruptured cerebral aneurysm in a 50-year-old female with idiopathic thrombocytopenic purpura was successfully clipped after preoperative high-dose gamma-globulin therapy to control the hemorrhagic diathesis. High-dose gamma-globulin therapy with or without steroid and/or platelet transfusion is recommended for such c...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.31.797

    authors: Terada T,Hayashi S,Tsuura M,Itakura T,Komai N

    更新日期:1991-12-01 00:00:00

  • Status and Future Perspectives of Utilizing Big Data in Neurosurgical and Stroke Research.

    abstract::The management, analysis, and integration of Big Data have received increasing attention in healthcare research as well as in medical bioinformatics. The J-ASPECT study is the first nationwide survey in Japan on the real-world setting of stroke care using data obtained from the diagnosis procedure combination-based pa...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.ra.2016-0174

    authors: Nishimura A,Nishimura K,Kada A,Iihara K,J-ASPECT Study GROUP.

    更新日期:2016-11-15 00:00:00

  • Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases.

    abstract::Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base. The treatment of these tumors affecting the skull base is complex due to the significant anatomical features. We examined 25 patients, 17 males and 8 females with mean age 61 +/- 2 years...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.20

    authors: Jimbo H,Kamata S,Miura K,Asamoto S,Tada S,Endo T,Masubuchi T,Nakamura N,Fushimi C

    更新日期:2010-01-01 00:00:00

  • Microcystic meningioma without enhancement on neuroimaging--case report.

    abstract::A 63-year-old female presented with an unusual case of microcystic meningioma manifesting as a 4-year history of unsteady gait, dysarthria, and hearing loss. Computed tomography disclosed a large hypodense mass in the right cerebellopontine angle, clivus, and middle fossa, with slight contrast enhancement. T1-weighted...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.37.407

    authors: Kubota Y,Ueda T,Kagawa Y,Sakai N,Hara A

    更新日期:1997-05-01 00:00:00

  • Central neurocytoma presenting with massive hemorrhage leading to coma--case report.

    abstract::A 21-year-old man presented with a hemorrhagic central neurocytoma manifesting as acute onset of disturbance of consciousness and right hemiparesis. Computed tomography (CT) demonstrated a tumor in the left lateral ventricle during the course of evaluation for mental alteration 12 days before onset, but the tumor was ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.139

    authors: Terakawa Y,Tsuruno T,Ishibashi K,Okada Y,Shimotake K,Murata T

    更新日期:2010-01-01 00:00:00