Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases.

Abstract:

:Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base. The treatment of these tumors affecting the skull base is complex due to the significant anatomical features. We examined 25 patients, 17 males and 8 females with mean age 61 +/- 2 years. En bloc resections using anterior skull base resection, orbital resection, middle fossa resection, and combined procedures of these three resections were performed. Using a combination of adjuvant radiation and chemotherapy, we have achieved a 2-year disease-free survival rate of 90% in these cases. However, potential complications include cerebrospinal fluid leakage, meningitis, abscess formation, pneumocephalus, frontal brain contusion, trismus, and dysphagia as a functional complication. We believe that the optimal management of such malignant tumors involves a multimodal and multidisciplinary team approach. Here we present our recent institutional experience and treatment policy employed during the past 3 years.

authors

Jimbo H,Kamata S,Miura K,Asamoto S,Tada S,Endo T,Masubuchi T,Nakamura N,Fushimi C

doi

10.2176/nmc.50.20

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

20-6; discussion 26

issue

1

eissn

0470-8105

issn

1349-8029

pii

JST.JSTAGE/nmc/50.20

journal_volume

50

pub_type

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