Growth and immunogenicity of human glioma in severe combined immunodeficiency-human mice.

Abstract:

:The severe combined immunodeficiency (SCID) mouse was investigated as a model system to study the growth and immunogenicity of human gliomas. Human glioma cell lines U-251MG, KNS-42, SF-188, A-172, and T-98G were injected subcutaneously into SCID mice. The cell lines U-251MG and KNS-42 grew as large, subcutaneous masses; SF-188, A-172, and T-98G did not grow. Glioma-immune system interactions were studied by the transplantation of human peripheral blood lymphocytes into tumor-bearing SCID mice. In the resultant SCID-human (SCID-hu) mice, transplanted lymphocytes infiltrated into the subcutaneously growing tumors and expressed the surface markers of human B, T, and natural killer cells. The SCID-hu mouse is a potentially powerful model to study the basic tumor biology of some human gliomas and also represents a useful screening system to evaluate experimental immunotherapies for brain tumors.

authors

Sawa H,Tamaki N,Kokunai T

doi

10.2176/nmc.36.286

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

286-95

issue

5

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/36.286

journal_volume

36

pub_type

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