Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk.

abstract：:A series of aromatic amidino compounds were investigated for their inhibitory effect on platelet agglutination and platelet aggregation. Agglutination of fresh or fixed platelets was produced by bovine plasma or by human plasma in combination with ristocetin, while aggregation of fresh platelets was induced by ADP, th...

journal_title：Thrombosis and haemostasis

authors： Geratz JD,Tidwell RR,Brinkhous KM,Mohammad SF,Dann O,Loewe H

更新日期：1978-04-30 00:00:00

abstract：:The alphaIIbeta3 receptor (GPIIb/IIIa) is the only platelet-specific integrin receptor and the most abundant adhesion/aggregation receptor on the surface of human platelets. Since mice are increasingly being used as models of human disease, we analyzed the structure and function of murine platelet alphaIIbeta3, utiliz...

journal_title：Thrombosis and haemostasis

authors： Smyth SS,Tsakiris DA,Scudder LE,Coller BS

更新日期：2000-12-01 00:00:00

abstract：:Three single nucleotide polymorphisms (-603A/G, -1322C/T, -1812C/T) and one deletion/insertion polymorphism (-1208D/I) are present in the tissue factor (TF) gene promoter sequence. These polymorphisms are in complete linkage disequilibrium, determining two haplotypes with almost equal frequency. The -603A/-1208D/-1322...

journal_title：Thrombosis and haemostasis

authors： Reny JL,Laurendeau I,Fontana P,Bièche I,Dupont A,Remones V,Emmerich J,Vidaud M,Aiach M,Gaussem P

更新日期：2004-02-01 00:00:00

abstract：:Mechanisms mediating initial adsorption of coagulation proteins to live cells were investigated. Adsorption kinetics were examined under varying flow conditions using tracer-dilution techniques in perfused spherical monolayers of cells expressing tissue factor. At biologically relevant time and concentration ranges, r...

journal_title：Thrombosis and haemostasis

authors： McGee MP,Teuschler H

更新日期：1999-07-01 00:00:00

abstract：:Abnormalities of Hageman factor dependent pathways have been described in a wide variety of human disease states. Congenital deficiencies of factor XII (Hageman trait) prekallikrein (Fletcher trait) and high molecular weight kininogen (Williams, Fitzgerald and Flaujeac traits) although resulting in profound in vitro c...

journal_title：Thrombosis and haemostasis

authors： Colman RW,Wong PY

更新日期：1977-12-15 00:00:00

abstract：:Platelets and coagulation are involved in bacterial colonisation of the host. Streptocococcus pneumoniae (pneumococcus) are important etiologic agents of respiratory tract infections in humans. The formation of pneumococci-platelet associations may facilitate haematogenous dissemination of pneumococci by providing an ...

journal_title：Thrombosis and haemostasis

authors： Niemann S,Kehrel BE,Heilmann C,Rennemeier C,Peters G,Hammerschmidt S

更新日期：2009-10-01 00:00:00

abstract：:D-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concerni...

journal_title：Thrombosis and haemostasis

authors： Alehagen U,Dahlström U,Lindahl TL

更新日期：2004-12-01 00:00:00

abstract：:The technique of crossed immunoelectrophoresis has been used to study the binding to purified antithrombin III (At III) of heparin and other mucopolysaccharides. The technique was unable to detect differences among samples of whole heparin from various manufacturers, but proved useful in studying the binding of hepari...

journal_title：Thrombosis and haemostasis

authors： Barrowcliffe TW

更新日期：1980-02-29 00:00:00

abstract：:The efficacy of conventional dose adjusted oral anticoagulation for stroke prevention in patients with non-valvular atrial fibrillation is well-documented but not considered ideal as primary antithrombotic treatment in elderly patients. The antithrombotic effect of fixed minidose warfarin 1.25 mg/day alone or in combi...

journal_title：Thrombosis and haemostasis

authors： Koefoed BG,Feddersen C,Gulløv AL,Petersen P

更新日期：1997-05-01 00:00:00

abstract：:Arterial stenosis results in a complex pattern of blood flow containing an extremely fast flow in the throat of stenosis and a post-stenosis low flow. The fast flow generates high shear stress that has been demonstrated in vitro to activate and aggregate platelets. One potential problem of these in vitro studies is th...

journal_title：Thrombosis and haemostasis

authors： Zhang JN,Bergeron AL,Yu Q,Sun C,McIntire LV,López JA,Dong JF

更新日期：2002-11-01 00:00:00

abstract：:We have identified a patient with a dysfunctional prothrombin that we have designated Prothrombin Frankfurt. The proband was characterized by a prothrombin activity level of 13% and 20% compared to normal controls using two different assays with a normal prothrombin antigen level of 91% of normal controls. The genetic...

journal_title：Thrombosis and haemostasis

authors： Degen SJ,McDowell SA,Sparks LM,Scharrer I

更新日期：1995-02-01 00:00:00

abstract：:It was the study objective to determine whether glycaemic control affects the extent of platelet inhibition by thienopyridines as assessed by vasodilator-stimulated phosphoprotein flow cytometry (VASP-FCT) in patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) during acute coronary...

journal_title：Thrombosis and haemostasis

authors： Morel O,El Ghannudi S,Hess S,Reydel A,Crimizade U,Jesel L,Radulescu B,Wiesel ML,Gachet C,Ohlmann P

更新日期：2012-08-01 00:00:00

abstract：:Many studies showed that the occurrence of cardiovascular and cerebrovascular events exhibits a seasonal and monthly variation. Evidences of a seasonal and monthly variation in the incidence of venous thromboembolism (VTE) are more conflicting. We conducted a systematic review and a meta-analysis of the literature to ...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Ageno W,Rancan E,Donati AV,Galli L,Squizzato A,Venco A,Mannucci PM,Manfredini R

更新日期：2011-09-01 00:00:00

abstract：:The effects of G4120, a cyclic Arg-Gly-Asp (RGD) containing peptide which inhibits fibrinogen binding to the platelet receptor GPIIb/IIIa, on thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) were investigated in a combined arterial and venous thrombosis model in heparinized dogs. The arterial th...

journal_title：Thrombosis and haemostasis

authors： Lu HR,Gold HK,Wu Z,Yasuda T,Pauwels P,Rapold HJ,Napier M,Bunting S,Collen D

更新日期：1992-06-01 00:00:00

abstract：:A group of 90 hemophiliacs who had been regularly treated with non virus-inactivated factor VIII or IX concentrates were studied in 1983. At that time 50 patients were HIV-1-antibody positive, 6 additional seroconversions occurred until 1985. 26 of the 50 patients seropositive in 1983 are currently asymptomatic. 4 pat...

journal_title：Thrombosis and haemostasis

authors： Stain C,Pabinger-Fasching I,Guggenberger K,Köller U,Stain M,Hartl H,Heinz F,Mayerhofer S,Kyrle PA,Lechner K

更新日期：1989-06-30 00:00:00

abstract：:In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure of the retina to revascularise its ischaemic areas. Non-resolving retina ischaemia/hypoxia results in upregulation of pro-angiogenic factors and pathologic neov...

journal_title：Thrombosis and haemostasis

authors： Economopoulou M,Avramovic N,Klotzsche-von Ameln A,Korovina I,Sprott D,Samus M,Gercken B,Troullinaki M,Grossklaus S,Funk RH,Li X,Imhof BA,Orlova VV,Chavakis T

更新日期：2015-11-25 00:00:00

abstract：:In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received considerable attention. The role initially attributed to EPCR, i.e. the enhancement of protein C (PC) activation by the thrombin-thrombomodulin complex on the surface of the large vessels, although important, did not go...

journal_title：Thrombosis and haemostasis

authors： Montes R,Puy C,Molina E,Hermida J

更新日期：2012-05-01 00:00:00

abstract：:Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

journal_title：Thrombosis and haemostasis

authors： Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

更新日期：2001-01-01 00:00:00

abstract：:A congenitally abnormal fibrinogen was isolated from blood of a young man with deep-vein thrombosis. Two other affected members of his family had three episodes of severe arterial thrombosis. The fibrinogen showed a delayed clotting by thrombin, but a normal clotting by Arvin, Reptilase, and prothrombin-staphylocoagul...

journal_title：Thrombosis and haemostasis

authors： Haverkate F,Koopman J,Kluft C,D'Angelo A,Cattaneo M,Mannucci PM

更新日期：1986-02-28 00:00:00

abstract：:Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised ...

journal_title：Thrombosis and haemostasis

authors： Monagle P,Barnes C,Ignjatovic V,Furmedge J,Newall F,Chan A,De Rosa L,Hamilton S,Ragg P,Robinson S,Auldist A,Crock C,Roy N,Rowlands S

更新日期：2006-02-01 00:00:00

abstract：:The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Fragments were analyzed for chain composition, heparin binding, collagen binding, platelet agglutinating activity and recognition by a panel of monoclonal antibodies which reacte...

journal_title：Thrombosis and haemostasis

authors： Bakhshi MR,Kirby EP

更新日期：1990-06-28 00:00:00

abstract：:Homocysteine is a sulfhydryl-containing amino acid formed during the metabolism of methionine. Rapidly accumulating evidence links elevated homocysteine levels to thrombosis via several mechanisms such as increased tissue factor expression, attenuated anticoagulant processes, enhanced platelet reactivity, increased th...

journal_title：Thrombosis and haemostasis

authors： Undas A,Brozek J,Szczeklik A

更新日期：2005-11-01 00:00:00

abstract：:Venous thromboembolism, which encompasses deep-vein thrombosis and acute pulmonary embolism (PE), represents a major contributor to global disease burden worldwide. For patients who present with cardiogenic shock or persistent hypotension (acute high-risk PE), there is consensus that immediate reperfusion treatment ap...

journal_title：Thrombosis and haemostasis

authors： Konstantinides SV,Wärntges S

更新日期：2015-06-01 00:00:00

abstract：:We investigated the presence of the gene mutation of factor V, FV R506Q or factor V Leiden, responsible for activated protein C resistance, in DNA samples of 127 probands and 188 relatives from 128 families with antithrombin deficiency. The factor V mutation was identified in 18 families. Nine families were available ...

journal_title：Thrombosis and haemostasis

authors： van Boven HH,Reitsma PH,Rosendaal FR,Bayston TA,Chowdhury V,Bauer KA,Scharrer I,Conard J,Lane DA

更新日期：1996-03-01 00:00:00

abstract：:There are conflicting views on the effects of age, gene source and familial severity on levels of factor VIII in carriers of haemophilia. Different workers have found that factor VIII increases with age, is higher in paternal carriers, and is higher in carriers from families with more severe haemophilia. Other workers...

journal_title：Thrombosis and haemostasis

authors： Duncan BM,Tunbridge LJ,Lloyd JV

更新日期：1983-10-31 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

更新日期：2019-09-01 00:00:00

abstract：:The correlation between homocysteine and vascular disease has been assessed in several clinical studies that demonstrated that elevation of plasma total homocysteine (tHcy) was an independent risk factor for atheriosclerotic disease. Major advances of homocysteine metabolism disorders have been made during the last fe...

journal_title：Thrombosis and haemostasis

authors： Di Minno MN,Tremoli E,Coppola A,Lupoli R,Di Minno G

更新日期：2010-05-01 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:We studied the recovery pattern of platelet malondialdehyde (MDA) formation after a single intake of various doses of aspirin (ASA). In normal subjects, there were striking differences in the recovery pattern between large doses (1,000 or 500 mg) and small doses (100 or 50 mg) of oral ASA. The 2 day lag phase was pres...

journal_title：Thrombosis and haemostasis

authors： Takayama H,Okuma M,Uchino H

更新日期：1982-08-24 00:00:00

abstract：:Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better the...

journal_title：Thrombosis and haemostasis

authors： Schouten M,van 't Veer C,Roelofs JJ,Gerlitz B,Grinnell BW,Levi M,van der Poll T

更新日期：2011-12-01 00:00:00