Surgical construction of an in vivo carotid siphon model to test neurovascular devices.

Abstract:

OBJECTIVE:We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS:The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS:Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION:Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Georganos SA,Guilbert F,Salazkin I,Gévry G,Raymond J

doi

10.1227/01.neu.0000119759.56437.f5

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

1239-43; discussion 1243

issue

5

eissn

0148-396X

issn

1524-4040

journal_volume

54

pub_type

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