Abstract:
OBJECTIVE:We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases. METHODS:The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination. RESULTS:Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes. CONCLUSION:Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Georganos SA,Guilbert F,Salazkin I,Gévry G,Raymond Jdoi
10.1227/01.neu.0000119759.56437.f5keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
1239-43; discussion 1243issue
5eissn
0148-396Xissn
1524-4040journal_volume
54pub_type
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