Abstract:
:Direct tissue profiling and imaging mass spectrometry (MS) provides a detailed assessment of the complex protein pattern within a tissue sample. MALDI MS analysis of thin tissue sections results in over of 500 individual protein signals in the mass range of 2 to 70 kDa that directly correlate with protein composition within a specific region of the tissue sample. To date, profiling and imaging MS has been applied to multiple diseased tissues, including human gliomas and nonsmall cell lung cancer. Interrogation of the resulting complex MS data sets has resulted in identification of both disease-state and patient-prognosis specific protein patterns. These results suggest the future usefulness of proteomic information in assessing disease progression, prognosis, and drug efficacy.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Chaurand P,Schwartz SA,Caprioli RMdoi
10.1021/pr0341282keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
245-52issue
2eissn
1535-3893issn
1535-3907journal_volume
3pub_type
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