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Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients.

Abstract：

:Voxel-based morphometry (VBM) allows the output of structural data in a Statistical Parametric Map of the brain in the same way that the SPM can do with functional data. Using functional magnetic resonance (fMR), we studied brain activation in 14 patients with schizophrenia and 14 matched normal controls. We found significant hypoactivation in patients in several regions, especially in the right hemisphere, in the dorsolateral frontal and temporal regions and in the inferior parietal. Subcortically, we found strong hypoactivity in the thalamus. The optimized VBM method revealed gray matter (GM) abnormalities in the bilateral supramarginal gyrus and cingulate cortex, and in the right inferior temporal regions. Three regions involved in attentional processes showed both structural and functional deficits: the thalamus, the anterior cingulate and the inferior parietal. The results suggest that these regions may be involved in the attentional deficit in schizophrenia.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Salgado-Pineda P,Junqué C,Vendrell P,Baeza I,Bargalló N,Falcón C,Bernardo M

doi

10.1016/j.neuroimage.2003.10.027

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

840-7

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053811903006773

journal_volume

21

pub_type

临床试验,杂志文章

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