当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Association of gephyrin and glycine receptors in the human brainstem and spinal cord: an immunohistochemical analysis.

Association of gephyrin and glycine receptors in the human brainstem and spinal cord: an immunohistochemical analysis.

Abstract：

:Gephyrin is a postsynaptic clustering molecule that forms a protein scaffold to anchor inhibitory neurotransmitter receptors at the postsynaptic membrane of neurons. Gephyrin was first identified as a protein component of the glycine receptor complex and is also colocalized with several GABAA receptor subunits in rodent brain. We have studied the distribution of gephyrin and glycine receptor subunits in the human brainstem and spinal cord using immunohistochemistry at light and confocal laser scanning microscopy levels. This study demonstrates the novel localization of gephyrin with glycine receptors in the human brainstem and spinal cord. Colocalization of immunoreactivities for gephyrin and glycine receptor subunits was detected in the dorsal and ventral horns of the spinal cord, the hypoglossal nucleus and the medial vestibular nucleus of the medulla. The results clearly establish that gephyrin is ubiquitously distributed and is colocalized, with a large proportion of glycine receptor subunits in the human brainstem and spinal cord. We therefore suggest that gephyrin functions as a clustering molecule for major subtypes of glycine receptors in the human CNS.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Baer K,Waldvogel HJ,During MJ,Snell RG,Faull RL,Rees MI

doi

10.1016/s0306-4522(03)00543-8

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

773-84

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306452203005438

journal_volume

122

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Anatomically distinct output channels of the caudate nucleus and orofacial dyskinesia: critical role of the subcommissural part of the globus pallidus in oral dyskinesia.

    abstract：:The findings in this feline study indicate that the enkephalin-positive subcommissural part of the globus pallidus, which is known to contain GABA and cholinergic cells projecting to the cortex, is innervated by the anterodorsal region of the caudate nucleus, but not by the core. Like stimulation of a particular subcl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90405-3

    authors： Cools AR,Spooren W,Bezemer R,Cuypers E,Jaspers R,Groenewegen H

    更新日期：1989-01-01 00:00:00

  • Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation.

    abstract：:In order to examine differential strain susceptibility to neurotoxic effects of amphetamine and to assess the potential role of superoxide radicals in amphetamine-induced dopaminergic damage, the drug was injected to mice with different levels of copper/zinc superoxide dismutase (Cu/Zn SOD) enzyme. Administration of a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00351-7

    authors： Krasnova IN,Ladenheim B,Jayanthi S,Oyler J,Moran TH,Huestis MA,Cadet JL

    更新日期：2001-01-01 00:00:00

  • Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus.

    abstract：:The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00425-3

    authors： Sershen H,Balla A,Lajtha A,Vizi ES

    更新日期：1997-03-01 00:00:00

  • C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1).

    abstract：:The transport of excitatory amino acids (EAA) in CNS is performed by a family of high affinity, sodium dependent carriers. One of these transporters, excitatory amino acid carrier 1 (EAAC1), is known to be regulated by several mechanisms that modify carrier abundance on the plasma membrane. Much less is known on EAAC1...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.11.055

    authors： Bianchi MG,Gazzola GC,Tognazzi L,Bussolati O

    更新日期：2008-02-19 00:00:00

  • Vascular expression of angiopoietin1, α5β1 integrin and tight junction proteins is tightly regulated during vascular remodeling in the post-ischemic brain.

    abstract：:The post-stroke angiogenic response is accompanied by changes of tight junctions (TJs) of the blood-brain barrier (BBB). However, the precise dynamic change of TJ proteins (TJPs) in the different stages of stroke-induced vascular remodeling and the molecules mediating these processes have yet to be fully defined. To i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.08.040

    authors： Sun J,Yu L,Huang S,Lai X,Milner R,Li L

    更新日期：2017-10-24 00:00:00

  • Minimum neuron density for synchronized bursts in a rat cortical culture on multi-electrode arrays.

    abstract：:To investigate the minimum neuron and neurite densities required for synchronized bursts, we cultured rat cortical neurons on planar multi-electrode arrays (MEAs) at five plating densities (2500, 1000, 500, 250, and 100 cells/mm(2)) using two culture media: Neuron Culture Medium and Dulbecco's Modified Eagle Medium su...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.08.038

    authors： Ito D,Tamate H,Nagayama M,Uchida T,Kudoh SN,Gohara K

    更新日期：2010-11-24 00:00:00

  • Early deprivation, atypical brain development, and internalizing symptoms in late childhood.

    abstract：:Children exposed to extreme early-life neglect such as in institutional rearing are at heightened risk for developing depression and anxiety disorders, and internalizing problems more broadly. These outcomes are believed to be due to alterations in the development of neural circuitry that supports emotion regulation. ...

    journal_title：Neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuroscience.2015.09.026

    authors： Bick J,Fox N,Zeanah C,Nelson CA

    更新日期：2017-02-07 00:00:00

  • Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease.

    abstract：:In an attempt to improve the survival of implanted dopamine cells, we have readdressed the optimal embryonic donor age for dopamine grafts. In a rat model of Parkinson's disease, animals with unilateral 6-hydroxydopamine lesions of the median forebrain bundle received dopamine-rich ventral mesencephalic grafts derived...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.03.037

    authors： Torres EM,Monville C,Gates MA,Bagga V,Dunnett SB

    更新日期：2007-06-08 00:00:00

  • Time required for transmitter accumulation inside monoaminergic storage vesicles differs in peripheral and in central systems.

    abstract：:Monoamine storage vesicles accumulate transmitters via an active transport process which presents similar pharmacological and bioenergetic properties in all monoaminergic systems. Using [3H]reserpine, a specific ligand of the vesicular monoamine transporter on isolated storage vesicles, we have determined the molecula...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90207-2

    authors： Scherman D,Boschi G

    更新日期：1988-12-01 00:00:00

  • Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks.

    abstract：:The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.04.027

    authors： Espeseth T,Endestad T,Rootwelt H,Reinvang I

    更新日期：2007-07-29 00:00:00

  • Acetylcholinesterase-containing neurons, substance P and enkephalin fibers in the ventral horns of developing human embryos and fetuses.

    abstract：:The presence of the acetylcholinesterase neurons and substance P-like and enkephalin-like fibers in the various nuclear columns of the ventral horns of the spinal cords was studied in the developing human by acetylcholinesterase histochemistry and substance P and enkephalin immunohistochemistry. Acetylcholinesterase-p...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90286-b

    authors： Luo CB,Yew DT,Zheng DR,Liu YQ

    更新日期：1992-06-01 00:00:00

  • The Effects of Mobile Phone Radiofrequency Electromagnetic Fields on β-Amyloid-Induced Oxidative Stress in Human and Rat Primary Astrocytes.

    abstract：:Amyloid beta peptide (Aβ) is implicated in the development of pathological reactions associated with Alzheimer's disease (AD), such as oxidative stress, neuro-inflammation and death of brain cells. Current pharmacological approaches to treat AD are not able to control the deposition of Aβ and suppression of Aβ-induced...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.058

    authors： Tsoy A,Saliev T,Abzhanova E,Turgambayeva A,Kaiyrlykyzy A,Akishev M,Saparbayev S,Umbayev B,Askarova S

    更新日期：2019-06-01 00:00:00

  • Stimulation of the inferior olivary complex alters the distribution of the type 1 corticotropin releasing factor receptor in the adult rat cerebellar cortex.

    abstract：:In a previous study, it was shown that populations of climbing fibers, derived from the inferior olivary complex (IOC) contain the peptide corticotropin releasing factor (CRF) and that the expression of this peptide in climbing fibers could be modulated by the level of activity in olivary afferents. The intent of this...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.01.076

    authors： Tian JB,King JS,Bishop GA

    更新日期：2008-04-22 00:00:00

  • Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices.

    abstract：:Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.075

    authors： Yoneshima H,Yamasaki S,Voelker CC,Molnár Z,Christophe E,Audinat E,Takemoto M,Nishiwaki M,Tsuji S,Fujita I,Yamamoto N

    更新日期：2006-01-01 00:00:00

  • Regional Fos-expression induced by γ-hydroxybutyrate (GHB): comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382.

    abstract：:γ-Hydroxybutyrate (GHB) has a complex array of neural actions that include effects on its own high-affinity GHB receptor, the release of neuroactive steroids, and agonist actions at GABAA and GABAB receptors. We previously reported partial overlap in the c-Fos expression patterns produced by GHB and the GABAB agonist,...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.07.056

    authors： van Nieuwenhuijzen PS,McGregor IS,Chebib M,Hunt GE

    更新日期：2014-09-26 00:00:00

  • The role of D2-autoreceptors in regulating dopamine neuron activity and transmission.

    abstract：:Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These Gi/o-coupled inhibitory receptors play a major part in shaping dopamine transmission. Found at both somatodendritic and axonal sites, autoreceptors regulate the firi...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.01.025

    authors： Ford CP

    更新日期：2014-12-12 00:00:00

  • Independent alterations in the central and peripheral somatosensory pathways in rat diabetic neuropathy.

    abstract：:Peripheral and central diabetic neuropathies were studied in streptozotocin-diabetic rats, using behavioral, biochemical and electrophysiological techniques. Diabetic rats showed thermal hypoalgesia and decreasing motor nerve conduction velocity at 4 and 8 weeks of diabetes. In addition, amplitude of the evoked potent...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.047

    authors： Piriz J,Torres-Aleman I,Nuñez A

    更新日期：2009-05-05 00:00:00

  • Ontogeny and distribution of GABAA receptors in rat brainstem and rostral brain regions.

    abstract：:Previous studies from our laboratory and others have shown that there are major age-related differences in brainstem neuronal function. Since GABAA receptors are major targets for GABA-mediated inhibitory modulation and play a key role in regulating cardiorespiratory function, especially during O2 deprivation, we exam...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90373-a

    authors： Xia Y,Haddad GG

    更新日期：1992-08-01 00:00:00

  • Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons.

    abstract：:Cerebellar Purkinje neurons have intracellular regulatory systems including Ca2+-binding proteins, intracellular Ca2+ stores, Ca2+-ATPase and Na+-Ca2+ exchanger (NCX) that keep intracellular Ca2+ concentration ([Ca2+]i) in physiological range. Among these, NCX interacts with AMPA receptors, activation of which induces...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.01.040

    authors： Kim YT,Namkung YL,Kwak J,Suh CK

    更新日期：2007-04-25 00:00:00

  • GABAergic synaptic communication in the GABAergic and non-GABAergic cells in the deep cerebellar nuclei.

    abstract：:The deep cerebellar nuclei (DCN) are the final integrative units of the cerebellar network. The strongest single afferent to the DCN is formed by GABAergic Purkinje neuron axons whose synapses constitute the majority of all synapses in the DCN, with their action strongly regulating the intrinsic activity of their targ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.07.060

    authors： Uusisaari M,Knöpfel T

    更新日期：2008-10-15 00:00:00

  • Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.

    abstract：:We investigated the electrophysiology of morphologically identified human granule cells with conventional current-clamp recordings. Slices were prepared from 14 human epileptic sclerotic hippocampi. Granule cells appeared to have a diverse electrophysiology. Each cell was distinguished by the shape of the afterhyperpo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00574-0

    authors： Dietrich D,Clusmann H,Kral T,Steinhäuser C,Blümcke I,Heinemann U,Schramm J

    更新日期：1999-01-01 00:00:00

  • Congruence of zebrin II expression and functional zones defined by climbing fiber topography in the flocculus.

    abstract：:The cerebellum is organized into parasagittal zones with respect to the topography of climbing fiber (CF) afferents and the expression of molecular markers such as zebrin II. Zebrin is expressed by a subset of Purkinje cells that are distributed as a parasagittal array of immunopositive and immunonegative stripes. Sev...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.08.062

    authors： Pakan JM,Wylie DR

    更新日期：2008-11-11 00:00:00

  • Ultrastructure and synaptic targets of the raphe-nigral projection in the rat.

    abstract：:A major input to the substantia nigra is from the 5-hydroxytryptamine-containing neurons in the dorsal raphe nucleus. In order to examine the morphology and distribution of this projection, rats were given injections of the anterograde tracers, Phaseolus vulgaris-leucoagglutinin or biocytin, in the dorsal raphe nucleu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90510-m

    authors： Corvaja N,Doucet G,Bolam JP

    更新日期：1993-07-01 00:00:00

  • Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells.

    abstract：:One class of spinal interneurons, the Renshaw cells, is able to discharge at very high frequencies in adult mammals. Neuronal firing at such high frequencies requires voltage-gated potassium channels to rapidly repolarize the membrane potential after each action potential. We sought to establish the pattern of express...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.048

    authors： Song ZM,Hu J,Rudy B,Redman SJ

    更新日期：2006-05-12 00:00:00

  • Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.

    abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90265-9

    authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

    更新日期：1985-08-01 00:00:00

  • Time course of effect of capsaicin on ultrastructure and histochemistry of substance P-immunoreactive nerves associated with the cardiovascular system of the guinea-pig.

    abstract：:Capsaicin, a neurotoxin which depletes substance P from primary afferent nerve fibres, was injected systematically into adult guinea pigs. The effects of capsaicin were studied by immunohistochemistry, electron microscopy and radioimmunoassay at times from 5 min to 1 year. Within 5 min after a single injection of caps...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90021-6

    authors： Papka RE,Furness JB,Della NG,Murphy R,Costa M

    更新日期：1984-08-01 00:00:00

  • Astrocytes-derived VEGF exacerbates the microvascular damage of late delayed RBI.

    abstract：:Overexpression of vascular endothelial growth factor (VEGF) is considered the most critical factor in radiation-induced brain injury (RBI). To investigate the role of VEGF and the mechanism underlying microvascular damage in RBI, wild type mice, and transgenic mice overexpressing VEGF derived from astrocytes, were sep...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.039

    authors： Zhou D,Huang X,Xie Y,Deng Z,Guo J,Huang H

    更新日期：2019-06-01 00:00:00

  • Response properties of the brainstem neurons of the cat following intra-esophageal acid-pepsin infusion.

    abstract：:Studies in humans have documented that acute acid infusion into the esophagus leads to decrease in threshold for sensations to mechanical distension of the esophagus. It is not known whether acid infusion leads to sensitization of brainstem neurons receiving synaptic input from vagal afferent fibers innervating the es...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.07.016

    authors： Medda BK,Sengupta JN,Lang IM,Shaker R

    更新日期：2005-01-01 00:00:00

  • Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes.

    abstract：:The impact of treating astrocytes with the astrocytic toxin l-alpha amino adipic acid (L-AAA) on neuronal outgrowth, complexity and synapse formation was assessed, using a model of astrocyte-neuronal interaction. Treatment of rat primary cortical neurons with conditioned media (CM) derived from astrocytes treated with...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.09.023

    authors： David J,O'Toole E,O'Reilly K,Thuery G,Assmann N,Finlay D,Harkin A

    更新日期：2018-11-10 00:00:00

  • HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral hemorrhage.

    abstract：:Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote vascular remodeling. Whether HMGB1 supports angiogenesis after ICH is unclear, as are the receptors and downstream signaling pathway(s) involved. We used the rat model of collagenase-induced ICH to determine whether HMGB1 a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.03.032

    authors： Lei C,Zhang S,Cao T,Tao W,Liu M,Wu B

    更新日期：2015-06-04 00:00:00