Abstract:
:We present a fatal case of rhino-orbital-cerebral zygomycosis in an 81-year old immunocompromised patient with a 18-year history of multiple myeloma. The patient initially presented with symptoms of an orbital complication, loss of vision after acute sinusitis and agranulocytosis. Endonasal sinus surgery with orbital decompression was performed. Within days a rapid visero-cerebral progression of necrosis developed finally causing the patient's death. Invasive fungal infections are generally characterized by diagnostic difficulties in the early stage and exhibit an extremely high mortality. Definitive diagnosis of rhino-orbital-cerebral zygomycosis caused by Rhizopus microsporus was made by histology, culture and polymerase chain reaction. Early diagnosis and treatment are imperative for the management of patients afflicted with this devastating and life-threatening fungal infection.
journal_name
HNOjournal_title
HNOauthors
Sudhoff H,Wagner M,Theegarten D,Rong Ming G,Bremer K,Heimann KD,Tintelnot K,Dazert Sdoi
10.1007/s00106-003-0815-0keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
908-11issue
11eissn
0017-6192issn
1433-0458journal_volume
51pub_type
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