[Proliferation behavior of cholesteatoma].

Abstract:

:Two types of growth can be observed clinically in cholesteatoma: an aggressive and a less aggressive type. In this study monoclonal antibodies to Ki-67 proliferation antigen, epidermal growth-related factor (EGFR) and collagen type IV were used to examine cholesteatoma specimens from 36 patients undergoing tympanomastoid surgery. Mitotic cells were found in various amounts in each sample and an increase was seen in tissue folds and recesses. No difference was observed between the aggressive and less aggressive types. The expression of EGFR was restricted to basal and suprabasal layers and showed no differences between the groups. Small defects of the basal membrane were seen frequently and reflected the invasive growth potential of the cholesteatoma epithelium. These results showed that clinically less aggressive cholesteatomas also have a high proliferation rate. As a consequence, leaving small rests of epithelium in situ during middle ear surgery increases the risk for recurrences. Morphologically, no differences could be observed between an aggressive and a less aggressive cholesteatoma.

journal_name

HNO

journal_title

HNO

authors

Hoppe F

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

710-5

issue

12

eissn

0017-6192

issn

1433-0458

journal_volume

43

pub_type

杂志文章

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