Abstract:
:Two types of growth can be observed clinically in cholesteatoma: an aggressive and a less aggressive type. In this study monoclonal antibodies to Ki-67 proliferation antigen, epidermal growth-related factor (EGFR) and collagen type IV were used to examine cholesteatoma specimens from 36 patients undergoing tympanomastoid surgery. Mitotic cells were found in various amounts in each sample and an increase was seen in tissue folds and recesses. No difference was observed between the aggressive and less aggressive types. The expression of EGFR was restricted to basal and suprabasal layers and showed no differences between the groups. Small defects of the basal membrane were seen frequently and reflected the invasive growth potential of the cholesteatoma epithelium. These results showed that clinically less aggressive cholesteatomas also have a high proliferation rate. As a consequence, leaving small rests of epithelium in situ during middle ear surgery increases the risk for recurrences. Morphologically, no differences could be observed between an aggressive and a less aggressive cholesteatoma.
journal_name
HNOjournal_title
HNOauthors
Hoppe Fsubject
Has Abstractpub_date
1995-12-01 00:00:00pages
710-5issue
12eissn
0017-6192issn
1433-0458journal_volume
43pub_type
杂志文章相关文献
HNO文献大全abstract::Extracranial meningiomas are rare tumors of the lateral skull base. A 37-year-old woman presented with tinnitus und progressive hearing loss of her right ear. A painful mass lesion was also palpable in her mandibular angle. CT and MRI scans revealed an intracranial mass with extension to the lateral skull base. These ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050358
更新日期:1999-01-01 00:00:00
abstract::The protective effect of Ca2+ antagonists in acoustic trauma was evaluated by morphometric analysis of the guinea pig cochlea. Damage to the outer and inner hair cells was significantly reduced. Ca2+ antagonists may exert a beneficial influence on the cellular membrane of the sensory cell or on the cochlear vasculatur...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::Interleukin 2 (IL-2) is predominantly produced by T-helper cells (TH1) having the phenotype CD4+, and by subpopulations of thymocytes after antigenic or mitogenic stimulation. IL-2 causes an indefinite growth of T-cells, and its function depends on binding to IL-2 receptors (IL-2R alpha and IL-2R beta). Thus the immun...
journal_title:HNO
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::Almost the complete spectrum of skin tumours can occur within the facial area, ranging from benign tumours of infancy to typical malignancies of old age. This spectrum is quiet heterogeneous and comprises every cell type within the skin as a possible origin for tumour growth. Among these are cells derived from the epi...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-009-1891-6
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:The therapy of choice in nasoseptal defects is reconstruction with vital respiratory mucosa; in particular, three-layer repair using the bridge-flap technique according to Schultz-Coulon is the most promising. Cases exceeding operative limitations can be treated with silastic buttons. Our aim was to overco...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-2072-3
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The impact of outpatient clinics on emergency health care has not yet been analyzed satisfactorily. This study aims to determine the importance of the Jena University Outpatient ENT Clinic in emergency health care. METHODS:In a retrospective study, all 1,884 emergency cases from 2008 were gathered and analy...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-011-2461-2
更新日期:2012-07-01 00:00:00
abstract::Malignancies of the nose, paranasal sinuses and anterior skull base are characterized by their hidden locations and late clinical manifestation. This explains why most of the patients at the University of Tübingen were diagnosed in an advanced tumor stage (15 T1/T2; 33 T3/T4). Surgical treatment was possible in 35 cas...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::A total of 57 children aged between 5 and 15 years underwent endoscopic ethmoid surgery for recurrent acute or chronic rhinogenic sinusitis, chronic sinusitis associated with bronchial asthma or chronic bronchitis, early rhinogenous orbital complications and paranasal sinus disease associated with mucoviscidosis. The ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Intraoperative measurements of local intracapillary hemoglobin oxygenation of the human cochlea via the round window membrane have been shown to be possible using the Erlangen microlight-guided spectrophotometer. The aim of the present study was to develop a new microlight guide suitable for measurements in ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050112
更新日期:1997-05-01 00:00:00
abstract::Voice range profile(VRP) measurement (Phonetography) was used for the evaluation of the vocal capabilities of 41 female (F) and 50 male (M) members of a nonprofessional choir. By means of an automatic VPR measurement system F0 and SPL dB(A) were determined and displayed real time, two-dimensionally. The speaking voice...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050464
更新日期:1999-09-01 00:00:00
abstract::Statutory implementation of a universal newborn hearing screening requires a continuous quality assurance monitoring. Therefore, at the Annual Meeting in 2007, the members of the German Society of Phoniatrics and Pediatric Audiology passed a recommendation on measures of quality assurance applied to newborn hearing sc...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-008-1878-8
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Thrombosis of the internal jugular vein is a rare and critical disease which can also be a complication of a benign oropharyngeal infection (Lemierre syndrome). PATIENT:A 62 year old patient underwent septomplasty, endonasal turbinectomy, paranasal sinus surgery and tonsillectomy. The postoperative course w...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-003-0846-6
更新日期:2004-03-01 00:00:00
abstract::Obstructive sleep apnea (OSA) is a common disease in children. It is defined by the onset of snoring, hypopneas or apneas with impaired sleep and daytime function. Obstruction of the upper airway during sleep is the underlying pathogenetic mechanism. It is caused either by an anatomic obstruction, increased airway col...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-010-2214-7
更新日期:2010-12-01 00:00:00
abstract::Menière's disease is recognized as the idiopathic form of recurrent inner ear disease with the trias of hearing loss, tinnitus and vertigo with aural fullness and Menière's syndrome as the non-idiopathic form. Subentities with unknown pathogenesis are Lermoyez' s syndrome and Tumarkin crises. A common pathogenetic fac...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-009-1915-2
更新日期:2009-05-01 00:00:00
abstract::This study describes the clinical course of a 31 year old woman who developed multiple anaerobic brain abscesses six days after tonsillectomy, followed by hemoparesis and dysarthria. In spite of craniotomy, repeated punctures and drainage of pus and high dose local and systemic antibiotics, there was an obvious deteri...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
abstract::Sixty patients suffering from an acute inner ear disease were treated by a combination of acetylsalicylic acid (Micristin), an inhibitor of platelet aggregation, and meclofenoxate (Cerutil), a nootropic drug. The success rate in 26 patients with acute isolated unilateral vestibular disorder was 73% (69% with complete ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the test-retest variability of the Acoustic Voice Quality Index (AVQI) and to investigate the weighting of the test's two components (sustained vowel and continuous speech) with regards to the final AVQI score. PATIENTS AND METHODS:During this study, 43 test subjects w...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-012-2649-0
更新日期:2013-05-01 00:00:00
abstract::In the literature there is very little information about the importance of diabetes mellitus for ear diseases. Therefore, this article gives an overview about contact points between endocrinological and otological problems in patients with diseases of the ear and pre-existing diabetes mellitus. In particular the focus...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-014-2902-9
更新日期:2014-11-01 00:00:00
abstract::Ten of 84 supraglottic carcinomas were treated by primary surgery, 32 by pre or post operative irradiation and 41 by primary irradiation and salvage surgery if recurrence developed. A comparison of the treatment results between these groups is not possible because of the lack of randomization. After follow up of 4.4 y...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::Measures taken to assure medical quality in hospital departments have focused on external quality control. Public health insurance organizations and the society of hospital holders in Germany have now agreed to carry out activities that aims not only at outcome but also at structural and procedural aspects of medical ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Fibrous dysplasia named after Jaffè and Lichtenstein is a benign, self-limiting disorder of the bone structure. The normal bone is replaced by cellular fibrous connective tissue. Fibrous dysplasia can be differentiated into monostotic and polyostotic forms and the McCune-Albright syndrome (combination of polyostotic a...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-003-0814-1
更新日期:2003-12-01 00:00:00
abstract::Intraoperative magnetic resonance imaging is a widely accepted method for resection control of glial tumors. Increasingly, it is also used during the resection of skull base tumors. Several studies have independently demonstrated an increase in the extent of resection in these tumors with improved prognosis for the pa...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0240-9
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Transoral laser microsurgery (TLM) is the method of choice for partial laryngectomy in Germany. In advanced stages, chemoradiotherapy is increasingly indicated for organ preservation. OBJECTIVE:This report considers the indications for and outcomes of supracricoid partial laryngectomy (SPL), also known as c...
journal_title:HNO
pub_type: 临床试验,杂志文章
doi:10.1007/s00106-015-0071-0
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Except for glucocorticoids there is a lack of neuroprotective medication in neurosurgical interventions. OBJECTIVE:An overview of clinical trials investigating administration of the calcium antagonist nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery is given. Basic research is ...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-017-0386-0
更新日期:2017-09-01 00:00:00
abstract::Supplemental to the previous publication on the results of surgery and/or radiotherapy, the application of various cytostatic drugs--neoadjuvant, sequential, simultaneous, alternating or adjuvant--in addition to surgery and/or radiotherapy in the treatment of hypopharynx carcinomas is subjected to critical analysis. E...
journal_title:HNO
pub_type: 杂志文章,评审
doi:
更新日期:1994-02-01 00:00:00
abstract::Due to the increasing incidence of hymenoptera venom allergies and the potentially life-threatening reactions, it is important for otolaryngologists working in allergology to have an understanding of modern diagnostic and treatment standards for this allergic disease. Molecular diagnosis with recombinant single allerg...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0274-z
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Amplitude modulation following responses (AMFR) allows good estimation of the hearing threshold due to the very narrow band excitation of the cochlea. Audiological use of AMFR requires knowledge of the relationship of these responses to the state of vigilance. The few studies published compared...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050731
更新日期:2001-03-01 00:00:00
abstract::Subclinical invasion of the facial nerve by acoustic neuromas may be identified preoperatively using conventional electroneurography (ENOG). The clinical application of extratemporal stimulation distal to the stylomastoid foramen is limited in these cases because of the more proximal site of the lesion. Transcranial m...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:UNLABELLED:PRESENT STATE OF KNOWLEDGE: There are currently no known acoustic parameters by which stuttering children can be appraised which will predict their subsequent speech fluency. AIM:To explain the significance of factors which perpetuate stuttering by using computer-based speech analysis of fluent speech for a...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050748
更新日期:2001-04-01 00:00:00
abstract::Tumoral lesions in the head and neck region represent a diagnostic and therapeutic challenge in otorhinolaryngologic routine. High-resolution ultrasound is usually able to guide diagnosis. Nevertheless, a definite differentiation between benign and malignant lesions can only be achieved by tissue biopsy. The various o...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-020-00981-3
更新日期:2021-01-08 00:00:00