Abstract:
:Activity within motor areas of the cortex begins to increase 1 to 2 s prior to voluntary self-initiated movement (termed the Bereitschaftspotential or readiness potential). There has been much speculation and debate over the precise source of this early premovement activity as it is important for understanding the roles of higher order motor areas in the preparation and readiness for voluntary movement. In this study, we use high-field (3-T) event-related fMRI with high temporal sampling (partial brain volumes every 250 ms) to specifically examine hemodynamic response time courses during the preparation, readiness, and execution of purely self-initiated voluntary movement. Five right-handed healthy volunteers performed a rapid sequential finger-to-thumb movement performed at self-determined times (12-15 trials). Functional images for each trial were temporally aligned and the averaged time series for each subject was iteratively correlated with a canonical hemodynamic response function progressively shifted in time. This analysis method identified areas of activation without constraining hemodynamic response timing. All subjects showed activation within frontal mesial areas, including supplementary motor area (SMA) and cingulate motor areas, as well as activation in left primary sensorimotor areas. The time courses of hemodynamic responses showed a great deal of variability in shape and timing between subjects; however, four subjects clearly showed earlier relative hemodynamic responses within SMA/cingulate motor areas compared with left primary motor areas. These results provide further evidence that the SMA and cingulate motor areas are major contributors to early stage premovement activity and play an important role in the preparation and readiness for voluntary movement.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Cunnington R,Windischberger C,Deecke L,Moser Edoi
10.1016/s1053-8119(03)00291-xkeywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
404-12issue
1eissn
1053-8119issn
1095-9572pii
S105381190300291Xjournal_volume
20pub_type
临床试验,杂志文章相关文献
NEUROIMAGE文献大全abstract::Self-related information, such as one's own face, is prioritized by our cognitive system. Whilst recent theoretical developments suggest that this is achieved by an interplay between bottom-up and top-down attentional mechanisms, their underlying neural dynamics are still poorly understood. Furthermore, it is still ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116754
更新日期:2020-06-01 00:00:00
abstract::Gestures are elemental components of social communication and aid comprehension of verbal messages; however, little is known about the potential role of gestures in facilitating processing of semantic complexity in an ecologically valid setting. The goal of this study was to investigate whether cognitive load, as inde...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.03.054
更新日期:2019-07-15 00:00:00
abstract::Diffusion tensor MRI is sensitive to the coherent structure of brain tissue and is commonly used to study large-scale white matter structure. Diffusion in gray matter is more isotropic, however, several groups have observed coherent patterns of diffusion anisotropy within the cerebral cortical gray matter. We extend t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.11.065
更新日期:2013-04-01 00:00:00
abstract::The recording of electrophysiological data during BOLD fMRI is highly challenging but provides the opportunity to develop a more thorough account of brain function than either modality alone. To develop new techniques in this area has often required the study of pathological electrophysiological measures because such ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.04.183
更新日期:2006-08-15 00:00:00
abstract::The core concept within the field of brain mapping is the use of a standardized, or "stereotaxic", 3D coordinate frame for data analysis and reporting of findings from neuroimaging experiments. This simple construct allows brain researchers to combine data from many subjects such that group-averaged signals, be they s...
journal_title:NeuroImage
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuroimage.2012.01.024
更新日期:2012-08-15 00:00:00
abstract::In this study, we examined the impact of goal-directed processing on the response to emotional pictures and the impact of emotional pictures on goal-directed processing. Subjects (N=22) viewed neutral or emotional pictures in the presence or absence of a demanding cognitive task. Goal-directed processing disrupted the...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.11.048
更新日期:2007-03-01 00:00:00
abstract:AIMS:Using functional magnetic resonance imaging (fMRI) we investigated the cortical and subcortical representations during bladder filling and the effect of simultaneous stimulation of the dorsal clitoral nerve on these cortical and subcortical structures. METHODS:After approval of the local ethics committee, 8 healt...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.03.006
更新日期:2008-07-01 00:00:00
abstract::As the use of ultra-high field (UHF; ≥7T) magnetic resonance (MR) imaging expands, there is an increasing need to establish high-resolution MR imaging protocols for patients with neurological disease. Magnetization transfer (MT) imaging has been used to provide information about changes in the magnitude of the restric...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.09.009
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behavior is through changes in functional connectivity. Graph theory is a powerful framework for quantify...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2016.12.003
更新日期:2017-10-15 00:00:00
abstract::Functional studies of auditory spatial attention generally report enhanced neural responses in auditory cortical regions. However, activity in regions of the spatial attentional network as described in the visual modality is not consistently observed. Data analysis limitations due to oppositely lateralized activity de...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Understanding the neuropathological underpinnings of mental disorders such as schizophrenia, major depression, and bipolar disorder is an essential step towards the development of targeted treatments. Diffusion MRI studies utilizing the diffusion tensor imaging (DTI) model have been extremely successful to date in ide...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2018.04.051
更新日期:2018-11-15 00:00:00
abstract::This manuscript examines the origins and nature of the function-derived activation detected by magnetic resonance imaging at ultrahigh fields using different encoding methods. A series of preclinical high field (7 T) and ultra-high field (17.2 T) fMRI experiments were performed using gradient echo EPI, spin echo EPI a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.03.018
更新日期:2015-06-01 00:00:00
abstract::This study examined within-subject differences among three fluid abilities that decline with age: reasoning, episodic memory and processing speed, compared with vocabulary, a crystallized ability that is maintained with age. The data were obtained from the Reference Ability Neural Network (RANN) study from which 221 p...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116809
更新日期:2020-07-15 00:00:00
abstract::Continuous EEG activity has been used increasingly as a marker of mental and cognitive states, with previous work linking particular neural patterns to conditions of arousal or fatigue. This approach is more commonly used to assess task-related, as opposed to resting-state activity. In this study, we recorded the EEG ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.03.018
更新日期:2013-08-01 00:00:00
abstract::Previous evidence suggests that relatively separate neural networks underlie initial learning of rule-based and information-integration categorization tasks. With the development of automaticity, categorization behavior in both tasks becomes increasingly similar and exclusively related to activity in cortical regions....
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.01.008
更新日期:2013-05-01 00:00:00
abstract::To investigate the cross-modal transfer of movement patterns necessary to perform melodies on the piano, 22 non-musicians learned to play short sequences on a piano keyboard by (1) merely listening and replaying (vision of own fingers occluded) or (2) merely observing silent finger movements and replaying (on a silent...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.03.038
更新日期:2012-11-01 00:00:00
abstract::The current experiment examined the neural substrates of response selection, comparing conditions that required participants to make criterion-free selections from sets of same-sex faces (i.e., inconsequential decision) to choosing a dinner date from opposite-sex faces (i.e., consequential decision). In each of these ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.02.037
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To examine the extent of genetic damage, assessed from deoxyribonucleic acid (DNA) double-strand breaks (DSBs) and micronuclei (MN) in peripheral blood mononuclear cells obtained from individuals repeatedly exposed to 7T Magnetic Resonance Imaging (MRI). MATERIALS AND METHODS:The study protocol was approved by...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.03.023
更新日期:2016-06-01 00:00:00
abstract::Twelve right-handed men performed two mental rotation tasks and two control tasks while whole-head functional magnetic resonance imaging was applied. Mental rotation tasks implied the comparison of different sorts of stimulus pairs, viz. pictures of hands and pictures of tools, which were either identical or mirror im...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1290
更新日期:2002-11-01 00:00:00
abstract::The ability to perceive facial expressions of emotion is essential for effective social communication. We investigated how the perception of facial expression emerges from the image properties that convey this important social signal, and how neural responses in face-selective brain regions might track these propertie...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.01.041
更新日期:2016-04-01 00:00:00
abstract::The cerebral cortex is anatomically organized at many physical scales starting at the level of single neurons and extending up to functional systems. Current functional magnetic resonance imaging (fMRI) studies often focus at the level of areas, networks, and systems. Except in restricted domains, (e.g., topographical...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.01.066
更新日期:2008-05-15 00:00:00
abstract::To investigate the spatial and temporal changes in electro-cortical brain activity and hand kinematics during the acquisition of an internal model of a novel screen-cursor transformation, we employed single-trial infomax independent component analysis (ICA), spectral estimation, and kinematics methods. Participants pe...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2003.10.037
更新日期:2004-03-01 00:00:00
abstract::The interpretation of the blood-oxygenation level-dependent (BOLD) post-stimulus undershoot has been a topic of considerable interest, as the mechanisms behind this prominent BOLD transient may provide valuable clues on the neurovascular response process and energy supply routes of the brain. Biomechanical theories ex...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.03.015
更新日期:2009-07-01 00:00:00
abstract::Rhythmic brain activity may reflect a functional mechanism that facilitates cortical processing and dynamic interareal interactions and thereby give rise to complex behavior. Using magnetoencephalography (MEG), we investigated rhythmic brain activity in a brain-wide network and their relation to behavior, while human ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117351
更新日期:2020-12-01 00:00:00
abstract::In human functional magnetic resonance imaging (fMRI), a characteristic pattern of frontal and parietal activity is produced by many different cognitive demands. Although frontoparietal cortex has been shown to represent a variety of task features in different contexts, little is known about detailed representation of...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.04.035
更新日期:2011-05-15 00:00:00
abstract::Changes in appetite in older adults may result in unhealthy weight change and negatively affect overall nutrition. Research examining gustatory processing in young adults has linked changes in patterns of the hemodynamic response of gustatory and motivation related brain regions to the physiological states of hunger a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.05.012
更新日期:2010-11-01 00:00:00
abstract::A method for postprocessing of segmented routine brain MRI studies providing automated definition of major structures (frontal, parietal, occipital, and temporal lobes; cerebellar hemispheres; and lateral ventricles) according to the Talairach atlas is presented. The method was applied to MRI studies from 25 normal su...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.2002.1157
更新日期:2002-09-01 00:00:00
abstract::The intention of our study was to compare functional magnetic resonance imaging (fMRI) with positron emission tomography (PET). We used the same force-related motor paradigm for both techniques, which allows for quantification of stimulus intensity. Regional cerebral blood flow (rCBF) was determined with PET in six ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1996.0071
更新日期:1996-12-01 00:00:00
abstract::Perception, motion, and cognition involve the formation of cooperative neuronal assemblies distributed over the cerebral cortex. It remains to explore what characterizes the assemblies, their location, and the structural substrate of assembly formation. In this EEG/fMRI study, we describe the response of the visual ar...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.07.045
更新日期:2006-01-15 00:00:00
abstract::Comparing the neural outcomes of two randomized experimental groups is a primary aim of many functional neuroimaging studies. However, between-group effects can be obscured by heterogeneity in neural responses. Optimal Combined Moderator (OCM) approaches have previously been used to clarify heterogeneity in clinical o...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.07.051
更新日期:2018-11-01 00:00:00