Abstract:
:The polymorphism CYP1A2*1F of the cytochrome 1A2 gene affects the inducibility of this cytochrome, which is involved in the metabolism of many commonly used drugs. We developed a rapid-cycle polymerase chain reaction (PCR) and fluorescent probe melting curve analysis on the LightCycler instrument for identification of this mutation. This new method was confirmed by genotyping 101 samples in parallel to restriction enzyme digestion. The 100% concordance of both methods showed the reliability of our high-speed genotyping assay, which is suitable for large epidemiological studies or routine clinical use.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Popp J,Messner B,Steimer Wdoi
10.1517/phgs.4.5.643.23798keywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
643-6issue
5eissn
1462-2416issn
1744-8042pii
PGS040511journal_volume
4pub_type
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