Abstract:
:The newt (Pleurodeles waltl) is an amphibian species used in a mutagenicity test (micronucleus). This study was carried out to establish if the inducibility of hepatic cytochromes P450 of this species is similar to that of the rat. Our results showed that the newt is characterized by a lower level of hepatic cytochrome P450-dependent activities than the rat. Variations of enzymatic activities according to sex and season were observed. Specific activities in newt were characterized by an almost complete insensitivity to induction by phenobarbital pretreatment. On the other hand, pretreatment by 3-methylcholanthrene resulted in an increase in the metabolism of several hydroxycoumarin and resorufin derivatives, similar to the effects observed in rat liver. Occurrence of specific forms of cytochromes P450 was assessed by specific antibodies.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Marty J,Rivière JL,Guinaudy MJ,Kremers P,Lesca Pdoi
10.1016/0147-6513(92)90042-2keywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
144-54issue
2eissn
0147-6513issn
1090-2414pii
0147-6513(92)90042-2journal_volume
24pub_type
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