当前位置： SCI文献检索 > ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY期刊下所有文献 > The uptake, metabolism, and biological half-life of benzo[a]pyrene administered by force-feeding in sea bass (Dicentrarchus labrax).

The uptake, metabolism, and biological half-life of benzo[a]pyrene administered by force-feeding in sea bass (Dicentrarchus labrax).

Abstract：

:The kinetics of uptake and metabolism of benzo[a]pyrene (BaP) were studied in various tissues of a marine fish, the sea bass (Dicentrarchus labrax), after intragastric administration of pellets containing a 14C-labeled compound. Only 25% of injected radioactivity was detected and it was found only in intestine, gallbladder, liver, and kidney. The major part of radioactivity was found in gallbladder (85% of the whole body radioactivity). The calculated half-lives determined after the decrease in radioactivity measured in these tissues were 8.2, 3.5, 3.3, and 0.8 days for liver, gallbladder, intestine, and kidney, respectively. The kinetics of distribution of radioactivity between alkali and hexane tissue extracts showed the high metabolization potential of intestine which represents the main site of BaP uptake by this route of exposure. The other organs received mainly metabolites brought by general blood circulation. Intragastric administration as an experimental exposure route compared to other exposure patterns and particularly intraperitoneal injection, which has been used previously in the same species and under the same experimental conditions for the same kind of study, is discussed.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Lemaire P,Lemaire-Gony S,Berhaut J,Lafaurie M

doi

10.1016/0147-6513(92)90062-8

keywords:

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

244-51

issue

2

eissn

0147-6513

issn

1090-2414

pii

0147-6513(92)90062-8

journal_volume

23

pub_type

杂志文章

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