Polyurethane-covered metal stent for management of distal malignant biliary obstruction.

Abstract:

BACKGROUND:The efficacy of polyurethane-covered metal expandable stents for treatment of neoplastic distal biliary obstruction was analyzed. METHODS:Twenty-one patients with unresectable malignant tumors involving the mid to distal bile duct who were seen with obstructive jaundice were consecutively enrolled. Eighteen patients underwent endoscopic implantation of a polyurethane-covered metal stent and 3 patients underwent transhepatic insertion because of duodenal obstruction. The stent patency, complications, and patient survival were analyzed. RESULTS:Effective biliary decompression was achieved in all patients. Adverse events were minor: mild pancreatitis (1) and cholecystitis (2) occurred within 7 days of stent insertion. Mean survival and stent patency were 233 days and 206 days, respectively. Stent occlusion occurred in 3 patients (14%) after a mean of 188 days. Tumor ingrowth through the stent mesh was not observed. However, 2 stents were occluded by tumor overgrowth and 1 by compacted alimentary debris. CONCLUSIONS:A polyurethane membrane may prevent tumor ingrowth and reduce the occlusion rate for expandable metal stents implanted in patients with malignant obstruction of the distal bile duct.

journal_name

Gastrointest Endosc

authors

Isayama H,Komatsu Y,Tsujino T,Yoshida H,Tada M,Shiratori Y,Kawabe T,Omata M

doi

10.1067/mge.2002.121876

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

366-70

issue

3

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(02)85244-0

journal_volume

55

pub_type

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