Abstract:
:The combined effects of injury from exposure to ionizing radiation and the potential biological warfare agent Venezuelan equine encephalitis (VEE) virus remain largely unknown. To study these effects, 4- to 5-week-old B6D2F1/J female mice were given a sublethal whole-body 7 Gy dose of 60Co gamma-photon radiation followed 48 hours later by aerosol or intraperitoneal challenge with enzootic VEE IIIA virus. Survival was observed for 30 days. A single sublethal 7 Gy dose of gamma radiation reduced the LD50/30 of VEE IIIA virus, in intraperitoneal challenged mice by a factor of 10(4) from 1.1 x 10(6) plaque-forming units (pfu) to 1 x 10(2) pfu, and in aerosol challenged mice, by a factor of 5 from 70 pfu to 14 pfu. These findings further confirm there is a combined effect of exposure to ionizing radiation and biological warfare agents, which could be devastating to unprotected populations and thus should be investigated further.
journal_name
Mil Medjournal_title
Military medicineauthors
Shoemaker MO,Tammariello R,Crise B,Bouhaouala SS,Knudson GB,Jackson WE 3rd,Ludwig GV,Smith JFkeywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
88-9issue
12 Suppleissn
0026-4075issn
1930-613Xjournal_volume
166pub_type
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