Abstract:
:The Department of Defense Familial Breast/Ovarian Cancer Research Project has offered genetic counseling and testing for BRCA1 and BRCA2 on a research basis to patients meeting specific diagnostic criteria, with risk for BRCA1 and BRCA2 mutations calculated based on the Couch model. In 2.5 years, 250 patients were evaluated and 101 patients met criteria requirements, including 33 who met criteria in more than one category. Ninety patients elected to undergo DNA testing. In this group of 90 patients, 14 mutations (15.5%) and 16 unclassified variants (17.7%) were identified. The most common inclusion criteria were onset of breast/ovarian cancer before age 45 years (n = 32) and onset of breast/ovarian cancer before age 45 years with strong family history (n = 21). However, when number of mutations and unclassified variants found were compared separately across all diagnostic criteria (including those of more than one capacity) using the chi 2 statistic, no significant differences were seen among the categories to suggest that one criterion was more predictive of mutations or variants than another. Couch risk values for patients with mutations showed a mean of 14% and ranged from 3.2 to 43.5% (range for all patients, 1.2-69.7%). These findings emphasize the importance of using multiple diagnostic criteria and suggest that a Couch risk value of > 3% may be useful in selecting patients for testing. The data also underscore the necessity of genetic counseling in the testing process, particularly given the large number of unclassified variants diagnosed and their uncertain status for disease predisposition.
journal_name
Mil Medjournal_title
Military medicineauthors
Fries MH,Holt C,Carpenter I,Carter CL,Daniels J,Flanagan J,Murphy K,Hailey BJ,Martin L,Hume R,Hudson G,Cadman M,Weatherly R,Nunes MEkeywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
99-103issue
2eissn
0026-4075issn
1930-613Xjournal_volume
167pub_type
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journal_title:Military medicine
pub_type: 杂志文章
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abstract::In addition to common stressors, members of the U.S. Armed Forces experience a high level of stress unique to their status as service members. In an effort to combat stress, many military personnel report high levels of nicotine use. This study investigated the relationship between tobacco use and perceived stress amo...
journal_title:Military medicine
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abstract::Community-acquired pneumonia can compromise readiness of recruits and service members operating in confined spaces. Often respiratory pathogens are implicated in outbreaks. In July 2008, 5 Basic Underwater Demolition/SEAL students entering an intense period of training at Naval Amphibious Base Coronado reported with c...
journal_title:Military medicine
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doi:10.7205/milmed-d-10-00370
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journal_title:Military medicine
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journal_title:Military medicine
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journal_title:Military medicine
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doi:10.7205/MILMED-D-14-00119
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
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journal_title:Military medicine
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doi:10.7205/milmed-d-01-6208
更新日期:2009-07-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-16-00307
更新日期:2017-05-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usx209
更新日期:2018-03-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
doi:10.7205/milmed-d-12-00145
更新日期:2012-11-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz172
更新日期:2020-02-12 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.10.1024
更新日期:2007-10-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00380
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.171.5.404
更新日期:2006-05-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usy059
更新日期:2018-11-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.11.1166
更新日期:2007-11-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-12-00223
更新日期:2013-04-01 00:00:00
abstract::The present review addresses the perceived stigma associated with admitting a mental health problem and seeking help for that problem in the military. Evidence regarding the public stigma associated with mental disorders is reviewed, indicating that the public generally holds negative stereotypes toward individuals wi...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/milmed.172.2.157
更新日期:2007-02-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-13-00180
更新日期:2013-11-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/MILMED-D-13-00393
更新日期:2014-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
doi:10.7205/milmed.170.11.931
更新日期:2005-11-01 00:00:00