Hungry bacteria--definition and properties of a nutritional state.

Abstract:

:Bacteria are sometimes neither starving nor under nutrient-excess conditions. When growing with suboptimal levels of nutrients, hungry bacteria express appropriate cellular responses. This review discusses approaches to defining the hunger response in both molecular and growth kinetic terms. The gene expression changes unique to hunger conditions are described, using Escherichia coli as the primary example. Metabolite changes with hunger and starvation and the differing role of the stationary phase regulator RpoS also lead to the hypothesis proposed in this review that bacteria undertake distinct approaches to hunger and starvation. Indeed, an understanding of the difference between hunger and starvation and the incompatibility between hunger and starvation responses explains some of the paradoxical mutational adaptations, such as rpoS inactivation, found in natural populations.

journal_name

Environ Microbiol

authors

Ferenci T

doi

10.1046/j.1462-2920.2001.00238.x

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

605-11

issue

10

eissn

1462-2912

issn

1462-2920

pii

238

journal_volume

3

pub_type

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