Abstract:
PURPOSE:Our goal was to demonstrate the appearance of phantom tastes and smells (phantageusia and phantosmia, respectively) by use of functional MRI (fMRI) of the brain and to demonstrate the efficacy of drug treatment that inhibited both the subjective presence of these phantoms and the fMRI brain activation initiated by these phantoms. METHOD:Multislice FLASH MR or echo planar MR brain scans were obtained in two patients with phantageusia and phantosmia in response to memory of two tastants (salt and sweet); memory of two odors (banana and peppermint); actual smell of amyl acetate, menthone, and pyridine; and memory of phantom tastes and smells before and after treatment with thioridazine and haloperidol. Activation images were derived using correlation analysis, and ratios of brain area activated to total brain area were obtained. RESULTS:Prior to treatment, both patients experienced persistent birhinal and global oral obnoxious tastes and smells in the absence of any external stimulus. The fMRI response to memory of phantoms was activation in sensory-specific brain regions for taste and smell, respectively. fMRI activation was greater than for memory of any tastant or odorant or for actual smell of any odor. After treatment with thioridazine or haloperidol, which successfully inhibited each phantom in each patient, fMRI response to phantom memory was significantly inhibited and was significantly lower than for memory of any tastant or odorant or actual smell of any odorant. CONCLUSION:These results demonstrate that (a) phantom taste and smell can be revealed by fMRI brain activation, (b) brain activation in response to taste and smell phantoms is localized in sensory-specific brain regions for taste and smell, respectively, (c) brain activation in response to memory of each phantom initiated the greatest degree of activation we had previously measured, and (d) treatment with thioridazine or haloperidol inhibited both the presence of each phantom and its associated fMRI brain activation. This is the first study in which phantom tastes and smells have been demonstrated by an objective technique and treatment that inhibited the phantoms was characterized by objective inhibition of fMRI activation. These two patients represent a relatively common group that may be classified as having primary phantageusia and phantosmia distinct from those with phantoms or auras secondary to neurological, migrainous, psychiatric, or other causes.
journal_name
J Comput Assist Tomogrjournal_title
Journal of computer assisted tomographyauthors
Henkin RI,Levy LM,Lin CSdoi
10.1097/00004728-200001000-00022keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
106-23issue
1eissn
0363-8715issn
1532-3145journal_volume
24pub_type
杂志文章abstract:PURPOSE:To retrospectively investigate the effect of the section thickness used for quantifying dual-energy perfusion computed tomography (DEpCT) during 2- and 3-dimensional evaluation. METHODS:Sixty-six patients (22 males and 44 females; mean age, 59.3 years) suspected of having an acute pulmonary embolism underwent ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000148
更新日期:2014-11-01 00:00:00
abstract::A case of an unusually large cystic renal cell carcinoma demonstrated on plain film, CT, and magnetic resonance (MR) is presented. Though the origin of huge abdominal tumors can be difficult to determine, the CT and MR findings were able to correctly diagnose the mass as a malignant cystic kidney tumor. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198911000-00026
更新日期:1989-11-01 00:00:00
abstract::We conducted a prospective evaluation of the normal vermiform appendix in 203 patients. Conventional CT techniques were utilized with an 8 mm slice thickness and 10 mm slice interval. The normal appendix was definitely identified in 51% of the patients studied. Computed tomographic appearance of the normal appendix is...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199107000-00009
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:To compare the efficacy and patient tolerance of iohexol and meglumine sodium diatrizoate as oral contrast agents for computed tomography (CT). SUBJECTS AND METHODS:One hundred patients were randomly assigned to drink 1000 mL of either meglumine sodium diatrizoate or iohexol 350 before their abdominopelvic CT ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,随机对照试验
doi:10.1097/RCT.0b013e3182058e76
更新日期:2011-03-01 00:00:00
abstract::A 31-year-old woman with an aneurysmal bone cyst of the L1 vertebral body proved by biopsy and studied by plain lumbar spine roentgenography, radionuclide studies, myelography, and CT is presented. The unusual location of involvement of the vertebral body alone and the difficulty in differential diagnosis between aneu...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198412000-00031
更新日期:1984-12-01 00:00:00
abstract::Endovascular stent grafting of abdominal aortic aneurysms is a new technique that may replace open surgery in selected cases. Pre-and postoperative angiography can be replaced by helical CT. This pictorial essay describes and illustrates the use of multislice helical CT where maximum intensity projection and multiplan...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200107000-00013
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:An anomalous origin and course of the coronary arteries can be benign or life threatening. Recently, because of new advances in computed tomography technology, radiologists have begun to interpret the diseases of coronary arteries. We aimed to demonstrate some remarkable anomalies of coronary arteries, some o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,多中心研究
doi:10.1097/01.rct.0000230004.38521.8e
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to quantify changes in uterine volume during and after chemotherapy for breast cancer. MATERIALS AND METHODS:Fifty-eight patients (mean age 42 years) with advanced breast cancer undergoing treatment with FLAC (5-fluorouracil, leucovorin, Adriamycin, and cyclophosphamide) were studi...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199507000-00016
更新日期:1995-07-01 00:00:00
abstract::Sternal hyperostosis is characterized by prominent new bone formation and fibrosis with less pronounced areas of granulation tissue and round cell infiltration. In previously reported cases the process involved not only the sternum but adjacent bony areas as well. Depending upon the extent of disease, acquiring biopsy...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199001000-00028
更新日期:1990-01-01 00:00:00
abstract::Several classification systems for neuroendocrine tumors (NETs) exist, which use variable terminology and criteria for grading and staging. This variability in terminology can cause confusion and difficulty in recognizing which tumors are, in fact, members of this heterogeneous group of malignancies. The largest group...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000000140
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the prevalence and etiologies of focal liver opacification (FLO) in the setting of superior vena cava (SVC) obstruction. METHODS:An archival search using key words to identify patients with SVC obstruction or severe narrowing and who had computed tomographic scans with intravenous ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e31829950a1
更新日期:2013-09-01 00:00:00
abstract::The magnetic resonance (MR) demonstration of a pituitary adenoma associated with McCune-Albright syndrome is presented. A useful role for routine MR imaging of the sella turcica in all cases of clinically suspected McCune-Albright syndrome is suggested. This is especially important in patients with leontiasis ossea se...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198907000-00026
更新日期:1989-07-01 00:00:00
abstract::Mucinous cystadenocarcinoma (MCA) is a rare tumor that is considered to be a cystic variant of mucin-producing lung adenocarcinoma. MCA expands grossly by storing mucus and contains few neoplastic cells. We present the CT images of three patients with MCA and correlate them with pathologic specimens. The CT findings o...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199907000-00028
更新日期:1999-07-01 00:00:00
abstract::We aim to review the imaging appearance of peripheral nerve sheath tumors (PNSTs) of head and neck according to updated fourth edition of World Health Organization classification. Peripheral nerve sheath tumor can be sporadic or associated with neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. S...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章,评审
doi:10.1097/RCT.0000000000001109
更新日期:2020-11-01 00:00:00
abstract::Two cases of papillary carcinoma of the bladder are presented in which the ureter could not be demonstrated by standard radiographic techniques. Computed tomography (CT) allowed identification of the tumor filled ureter. Intraureteral papillary tumor has a radiographic density (CT number) above that of water but less ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-197908000-00007
更新日期:1979-08-01 00:00:00
abstract:PURPOSE:Our purpose was to determine what represents normal findings on MR examinations of the lumbar spine in the immediately postoperative period following lumbar laminectomy with retained Surgicel. METHOD:MR examinations were performed immediately following lumbar laminectomy in 10 patients referred for symptoms of...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199911000-00029
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:The goal of our study was to assess the prevalence of pseudolesion in segment IV of the liver on MRI in patients with and without liver cirrhosis. METHOD:Patients were divided into three groups: 10 patients with angiographically confirmed aberrant gastric venous drainage and liver cirrhosis (Group 1), 250 cons...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199901000-00014
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To evaluate regional, remote, and global effects of percutaneous transluminal septal myocardial ablation (PTSMA) in hypertrophic obstructive cardiomyopathy (HOCM) using magnetic resonance (MR) imaging. METHODS:Twenty-one patients with HOCM underwent cine and delayed contrast-enhanced MR imaging. The regional...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/rct.0b013e31803151fd
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:The goal of our study was to examine the prevalence of multiple hypodense splenic nodules and their associated diagnoses and to correlate CT appearance with clinical presentation and diagnosis. METHOD:Records of all patients undergoing contrast-enhanced CT from July 1994 through September 1997 were reviewed. C...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199809000-00005
更新日期:1998-09-01 00:00:00
abstract::Computed tomography and magnetic resonance (MR) studies were done in one case of Behcet disease and showed a focal lesion in the upper brain stem. Early institution of therapy was followed by a complete clinical remission and disappearance of the CT and MR changes. Computed tomography and MR are important modalities f...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198603000-00027
更新日期:1986-03-01 00:00:00
abstract::A case of simultaneous renal vein thrombosis and bilateral adrenal hemorrhage is presented, demonstrating the ability of magnetic resonance (MR) imaging to identify these abnormalities without the use of intravenous contrast agents or radiopharmaceuticals. Adrenal hemorrhage appeared as markedly enlarged adrenal gland...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198607000-00028
更新日期:1986-07-01 00:00:00
abstract::Pseudodynamic MR imaging of the temporomandibular joints (TMJs) has been used for the evaluation of the functional aspects of the TMJs. To evaluate the value of T1-weighted spin-echo (SE) and gradient-echo (GE) techniques, both techniques were performed in 9 asymptomatic (mean 25.7 years, 22-23 years), and 25 symptoma...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199605000-00025
更新日期:1996-05-01 00:00:00
abstract::Kinetic analysis of 18F-labeled 2-fluoro-2-deoxy-D-glucose (2FDG) has been carried out in 28 studies on 25 subjects. The object of the analysis was to determine the practical problems of quantitation of glucose metabolic rate (GMR) using the Sokoloff model with 2FDG. We found that arterial and venous plasma concentrat...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-198310000-00038
更新日期:1983-10-01 00:00:00
abstract::A case in which pus within a bladder diverticulum simulated a deep pelvic abscess is presented. This pitfall in CT diagnosis should be considered in patients with bladder outlet obstruction with symptoms of infection. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199105000-00031
更新日期:1991-05-01 00:00:00
abstract::Temporomandibular joint (TMJ) disease is uncommon in children but frequently occurs in juvenile rheumatoid arthritis (JRA). Involvement is often asymptomatic; however, it can lead to growth disturbances and facial deformity. Thirty TMJs in 15 children (11 girls and 4 boys aged 3.5-18 years) with JRA were evaluated cli...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199305000-00022
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether liver extracellular volume (ECV) measured using equilibrium computed tomography (EQ-CT) can be used to quantitatively assess doxorubicin-induced liver injury (DILI). METHODS:The ethical approval was obtained from the Institutional Animal Care and Use Committee...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0000000000000968
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Our goal was to determine the predictive value of coronary artery calcification (CAC) on preoperative CT of the thorax for cardiac complications of noncardiac thoracic surgery. METHOD:Of 117 patients undergoing noncardiac thoracic surgical procedures between January 1, 1993, and June 1, 1995, at our institutio...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-199707000-00018
更新日期:1997-07-01 00:00:00
abstract:PURPOSE:To investigate the apparent diffusion coefficients (ADCs) of the normal uterine zonal structures (myometrium, endometrium, and junctional zone) during different phases of the menstrual cycle among premenopausal women with different age groups. MATERIALS AND METHODS:Magnetic resonance (MR) images of 67 healthy ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/RCT.0b013e3182418885
更新日期:2012-01-01 00:00:00
abstract::This is the fourth in a series of articles on the spine. The first reviewed the anatomy of the neck; the second reviewed the upper thoracic spine and chest (T1-T4); and the third reviewed the middle thoracic spine and chest (T5-T8). The procedures performed in the lower thoracic spine include percutaneous biopsies of ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/01.rct.0000237813.26301.73
更新日期:2007-01-01 00:00:00
abstract::Retroperitoneal fat necrosis is a well-known complication of acute pancreatitis. We describe an unusual case of fat necrosis presenting as multiple, bilateral renal pseudotumors in a patient with acute pancreatitis. The imaging findings on CT and MR are discussed. ...
journal_title:Journal of computer assisted tomography
pub_type: 杂志文章
doi:10.1097/00004728-200103000-00014
更新日期:2001-03-01 00:00:00